Subscribe Now Subscribe Today
Research Article
 

Preliminary Investigation on the Phytochemistry and Antimicrobial Activity of Senna alata L. Leaves



M. Idu , F.E. Oronsaye , C.L. Igeleke , S.E. Omonigho , O.E. Omogbeme and B.A. Ayinde
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
ABSTRACT

The phytochemistry and antimicrobial effects of water, methanol, chloroform and petroleum ether extracts of Senna alata leaves were studied. Extracts tested at a final concentration of 500 μg mL produced in vitro antimicrobial activities in assays against clinical isolates of Staphylococus aureus, Candida albicans, Escherichia coli, Proteus vulgaris, Pseudomonans aeruginosa and Bacillus subtilis. The zones of inhibitions produced by the extracts in agar diffusion assay against the test micro organisms ranged from 8 to 20 mm while the gentamycin antibiotic control produced zones that measured 5 mm. Preliminary phytochemical analysis of the plant extracts showed the presence of phenols, tannins, anthraquinoes, saponins, flavonoids.

Services
Related Articles in ASCI
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

M. Idu , F.E. Oronsaye , C.L. Igeleke , S.E. Omonigho , O.E. Omogbeme and B.A. Ayinde , 2006. Preliminary Investigation on the Phytochemistry and Antimicrobial Activity of Senna alata L. Leaves. Journal of Applied Sciences, 6: 2481-2485.

DOI: 10.3923/jas.2006.2481.2485

URL: https://scialert.net/abstract/?doi=jas.2006.2481.2485

REFERENCES

  1. Abatan, M.O., 1990. A note on the anti-inflammatory actions of plants of some Cassia species. Fioterapia, 61: 336-338.
    Direct Link  |  


  2. Adebayo, O., W.A. Anderson, M. Moo-Young and D.O. Kolawole, 1999. Antifungal properties of some components of Cassia alata flower. Pharmaceutical Biol., 37: 369-374.
    Direct Link  |  


  3. Ahmad, I., Z. Mehmood and F. Mohammad, 1998. Screening of some Indian medicinal plants for their antimicrobial properties. J. Ethnopharmacol., 62: 183-193.
    CrossRef  |  PubMed  |  Direct Link  |  


  4. Avirutant, W. and A. Pongpan, 1983. The antimicrobial activity of some Thai flowers and plants. Mahidol Universal J. Pharm. Sci., 10: 81-86.


  5. Benjamin, T.V. and A. Lamikaria, 1981. Investigations of Cassia alata, a plant used in Nigeria in the treatment of skin diseases. Quarterly J. Crude Drug Res., 19: 93-96.
    CrossRef  |  Direct Link  |  


  6. Crockett, C.O., E. Guede-Guina, O. Pugh, T.L. Vangah-Manda, T.T. Robinson, J.O. Olubacheiro and R.F. Ochillo, 1992. Cassia alata and the preclinical search for therapeutic agents for the treatment of opportunistic infection in AIDs patients. Cell Mol. Biol., 38: 799-802.


  7. Giron, L.M., V. Freire, A. Alonzo and A.J. Caceres, 1991. Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala. J. Ethnopharmacol., 34: 173-187.
    PubMed  |  Direct Link  |  


  8. Hasan, C.M., S.N. Islam, K. Begun, M. Ilias and A. Hassain, 1988. Antibacterial activities of the leaves and stem barks of Cassia alata. Bangladesh J. Bot., 17: 135-139.


  9. Holdsworth, O., 1992. Medicinal plants of the gazelkle peninsula, New Britain Island, Papua New Guinea, part I. Int. J. Pharmacognosy, 30: 185-190.
    CrossRef  |  Direct Link  |  


  10. Ibrahim, D. and H. Osman, 1995. Antimicrobial activity of Cassia alata from Malaysia. J. Ethnopharmacol., 45: 151-156.
    CrossRef  |  Direct Link  |  


  11. Ikenebomeh, M.J. and P.O. Metitiri, 1988. Antimicrobial effect of an extract from Cassia alata. Nig. J. Microbiol., 8: 12-23.


  12. Iwu, M.W., D.R. Duncan and C.O. Okunji, 1999. New Antimicrobials of Plant Origin. In: Perspective on New Crops and New Uses, J. Janick (Ed.). ASHS Press, Alexandria, pp: 107-108


  13. Limserimanee, S. and S. Sirinatana, 1983. Inhibitory actions of some Thai herbs (Medicinal Plants) to fungi. Undergraduate Special.


  14. Macfoy, C.A. and A.M. Sanna, 1983. Medicinal plants in Pujehun district of Sierra Leone. J. Ethnopharmacol., 8: 215-223.
    PubMed  |  Direct Link  |  


  15. Ogunti, E.O., A.J. Aladesanmi and S.A. Adesanya, 1991. Antimicrobial activity of Cassia alata. Fiototerapia, 62: 532-539.


  16. Ogunti, E.O. and A.A. Elujobi, 1993. Laxative activity of Cassia alata. Fitoterapia, 64: 437-439.
    Direct Link  |  


  17. Perry, L.M. and J. Metzger, 1980. Medicinal Plants of East and Southern Asia: Attribute Properties and Uses. The MIT Press, Cambridge, pp: 480


  18. Pinner, R.W., S.M. Teutsch, L. Simonsen, L.A. Klug, J.M. Graber, M.J. Clarke and R.L. Berkelman, 1996. Trends in infectious diseases mortality in the United States. J. Am. Med. Asso., 275: 189-193.
    PubMed  |  


  19. Rabe, T. and J. van Staden, 2000. Isolation of an antimicrobial sesquiterpenoid from Warbugie salutaris. J. Ethnopharcol., 93: 171-174.
    CrossRef  |  Direct Link  |  


  20. Sainsbury, M. and E.A. Sofowora, 1971. Essential oil from the leaves and inflorescence of Ocimum gratissium. Phytochemistry, 10: 2-3.


  21. Somchit, M.N., I. Reezal, I.E. Nur and A.R. Mutalib, 2003. In vivo antimicrobial activities of ethanol and water extracts of Cassia alata. J. Ethnopharmacol., 84: 1-4.


  22. Stokes, E.J., 1975. Clinical Bacteriology. 4th Edn., Edward Arnold Publishers, London, pp: 203-261


  23. Trease, G.E. and W.C. Evans, 1996. Pharmacognosy. Macmillan Publishers Ltd., London, pp: 213-832


  24. Vaijayanthimala, J., C. Anandi, V. Udhaya and K.V. Pugalendi, 2000. Anticandidal activity of certain south Indian medicinal plants. Phytother. Res., 14: 207-209.
    PubMed  |  Direct Link  |  


  25. Sansores-Peraza, P., M. Rosado-Vallado, W. Brito-Loeza, G.J. Mena-Rejon and L. Quijano, 2000. Cassine, an antimicrobial alkaloid from Senna racemosa. Fitoterapia, 71: 690-692.
    CrossRef  |  Direct Link  |  


©  2022 Science Alert. All Rights Reserved