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Research Article
 

Effects of Agouti Related Protein and Androgens on Growth



Akin Pala
 
ABSTRACT

A dominant mutation at the agouti locus on mouse chromosome 2 is a promoter of overeating and increased linear growth. Agouti related protein, which can be produced using bacteria can be used to reproduce the same growing effect. Androgens are known to promote leanness and increased growth. Combined effects of testosterone and agouti may provide fast growing-lean animals.

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  How to cite this article:

Akin Pala , 2003. Effects of Agouti Related Protein and Androgens on Growth. Journal of Applied Sciences, 3: 197-202.

DOI: 10.3923/jas.2003.197.202

URL: https://scialert.net/abstract/?doi=jas.2003.197.202

REFERENCES
Arnold, A.M., J.M. Peralta and M.L. Thonney, 1997. Effects of testosterone on differential muscle growth an on protein and nucleic acid concentrations in muscles of growing lambs. J. Anim. Sci., 75: 1495-1503.
Direct Link  |  

Bergen, H.T., T.M. Mizuno, J. Taylor and C.V. Mobbs, 1998. Hyperphagia and weight gain after gold-thioglucose: Relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology, 139: 4483-4488.
CrossRef  |  Direct Link  |  

Blanchard, S.G., C.O. Harris, O.R. Ittoop, J.S. Nichols, D.J. Parks, A.T. Truesdale and W.O. Wilkison, 1995. Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line. Biochem., 34: 10406-10411.
Direct Link  |  

Boston, B.A., K.M. Blaydon, J. Varnerin and R.D. Cone, 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Sci., 278: 1641-1644.
Direct Link  |  

Bultma, S.J., E.J. Michaud and R.P. Woychik, 1992. Molecular characterization of the mouse agouti locus. Cell, 71: 1195-1204.
Direct Link  |  

De-Wied, D. and J. Jolles, 1982. Neuropeptides derived from pro-opiocortin: Behavioral, physiological and neurochemical effects. Physiol. Rev., 62: 976-1059.
Direct Link  |  

Dvorak, M., 1981. Effect of neonatal pig administration of testosterone on piglet growth. Vet Med., 226: 65-70.

Fan, W., B. Boston, R. Kesterson, V. Hruby and R. Cone, 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature, 385: 165-168.

Fan, W., B.A. Boston, R.A. Kesterson, V.J. Hruby and R.D. Cone, 1997. Melanocortinergic inhibition of feeding behavior and disruption with an Agouti-mimetic. Nature, 9: 165-168.
Direct Link  |  

Florini, J.R., 1970. Effects of testosterone on qualitative pattern of protein synthesis in skeletal muscle. Biochemistry, 9: 909-912.
CrossRef  |  

Himms-Hagen, J., 1985. Brown adipose tissue metabolism and thermogenesis. Annu. Rev. Nutr., 5: 69-94.
CrossRef  |  

Huszar, D., C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore and Q. Fang et al., 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell, 88: 131-141.
CrossRef  |  Direct Link  |  

Leibel, R.L., W.K. Chung and S.C. Chua, 1997. The molecular genetics of rodent single gene obesities. J. Biol. Chem., 272: 31937-31940.
Direct Link  |  

Lu, D., D. Willard, I.R. Patel, S. Kadwell, and L. Overton et al., 1994. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature, 371: 799-802.
CrossRef  |  

Manne, J., A.C. Argeson and L.D. Siracusa, 1995. Mechanisms for the pleiotropic effects of the agouti gene. Proc. Nat. Acad. Sci. USA., 92: 4721-4724.
Direct Link  |  

Mooradian, A.D., J.E. Morley and S.G. Korenman, 1987. Biological actions of androgens. Endocrine Rev., 8: 1-28.
CrossRef  |  Direct Link  |  

Mulvaney, D.R., D.N. Marple and R.A. Merkel, 1988. Proliferation of skeletal muscle satellite cells after castration and administration of testosterone propionate. Proc. Soc. Exp. Biol. Med., 188: 40-45.
Direct Link  |  

Ollmann, M.M., B.D. Wilson, Y.K. Yang, J.A. Kerns, Y. Chen, I. Gantz and G.S. Barsh, 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science, 278: 135-138.
Direct Link  |  

Ollmann, M.M., M.L. Lamoreux, B.D. Wilson and G.S. Barsh, 1998. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev., 12: 316-330.
Direct Link  |  

Palmiter, R.D., J.C. Erickson, G. Hollopeter, S.C. Baraban and M.W. Schwartz, 1998. Life without neuropeptide Y. Recent Prog. Horm. Res., 53: 163-199.
Direct Link  |  

Poole, T.W. and W.K. Silvers, 1976. An experimental analysis of the recessive yellow coat color mutant in the mouse. Dev. Biol. Feb., 48: 377-381.
Direct Link  |  

Roberts, S.B. and A.S. Greenberg, 1996. The new obesity genes. Nut. Rev., 54: 41-49.

Rooyackers, O.E. and K.N. Sreekumaran, 1997. Hormonal regulation of human muscle protein metabolism. Annu. Rev. Nutr., 17: 457-485.
Direct Link  |  

Rosenfeld, R.D., L. Zeni, A.A. Welcher, L.O. Narhi and C. Hale et al., 1998. Biochemical, biophysical and pharmacological characterization of bacterially expressed human agouti-related protein. Biochemistry, 37: 16041-16052.
CrossRef  |  PubMed  |  Direct Link  |  

Shutter, J.R., M. Graham, A.C. Kinsey, S. Scully, R. Luthy and K.L. Stark, 1997. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev., 11: 593-602.
Direct Link  |  

Siegrist, W., D.H. Willard, W.O. Wilkison and A.N. Eberle, 1996. Agouti protein inhibits growth of B16 melanoma cells in vitro by acting through melanocortin receptors. Biochem. Biophys. Res. Commun., 218: 171-175.

Siegrist, W., R. Drozdz, R. Cotti, D.H. Willard, W.O. Wilkison and A.N. Eberle, 1997. Interactions of alpha-melanotropin and agouti on B16 melanoma cells: Evidence for inverse agonism of agouti. J. Recept Signal Transduct Res., 17: 75-98.
Direct Link  |  

Willard, D.H., W. Bodnar, C. Harris, L. Kiefer and J.S. Nichols et al., 1995. Agouti structure and function: Characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist. Biochemistry, 34: 12341-12356.
Direct Link  |  

Yang, Y.K., M.M. Ollmann, B.D. Wilson, C. Dickinson, T. Yamada, G.S. Barsh and I. Gantz, 1997. Effects of recombinant agouti-signaling protein on melanocortin action. Mol. Endocrinol., 11: 274-280.
Direct Link  |  

Yen, T.T., A.M. Gill, L.G. Frigeri, G.S. Barsh and G.L. Wolff, 1994. Obesity, diabetes and neoplasia in yellow A(vy)/- mice: Ectopic expression of the agouti gene. FASEB. J., 8: 479-488.
Direct Link  |  

Zemel, M.B., 1998. Nutritional and endocrine modulation of intracellular calcium: Implications in obesity, insulin resistance and hypertension. Mol. Cell. Biochem., 188: 129-136.
CrossRef  |  PubMed  |  

Zernel, M.B. and X. Bingzhong, 1998. Agouti/Melanocortin Interactions with Leptin Pathways in obesity. Nutr. Rev., 54: 271-274.

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