Subscribe Now Subscribe Today
Abstract
Fulltext PDF
References
Research Article
 

Performance, Safety and Tissue Residue Study for Coated Sodium Butyrate Added to Broiler Feed



Laurie C. Dolan, Steve Moreland, Mauro Morlacchini, Marco Spagnoli and Giorgio Fusconi
 
ABSTRACT

The aim of this study was to evaluate whether administration of feed containing 0.1, 0.5 or 1.0% fat-coated sodium butyrate (coated sodium butyrate) to one-day old broiler chicks for 49 consecutive days caused toxicity to the animals, or altered the fatty acid profile or butyric acid metabolite concentrations (ß-hydroxybutyrate, acetoacetate and acetone) of ingestible tissues compared to control animals. Treatment groups that consumed coated sodium butyrate exhibited low mortality and good general health. No statistical differences were found between groups for performance parameters, with the exception of the feed: gain ratio in the period D0-D21, which was improved by coated sodium butyrate at the 1.0% concentration. There was no effect of coated sodium butyrate on hematology, clinical chemistry, organ weight or organ histology of broiler chickens. The fatty acid profile of breast, liver, kidney or subcutaneous fat (with skin) tissues from chickens fed diets containing coated sodium butyrate did not differ from control chickens, with the exception of a statistically significant decrease in palmitoleic acid (C16:1) in liver tissue in the 0.5% and 1.0% groups. Small, dose-dependent, toxicologically insignificant increases in tissue levels of butyric acid and its metabolites occurred in edible tissues, which were expected based on the dose-dependent absorption of butyric acid into plasma. The results show that coated sodium butyrate may be safely used in poultry feed at up to 10,000 g/tonne feed (1.0%), from the day of hatching to 49 days of age.

Services
Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Laurie C. Dolan, Steve Moreland, Mauro Morlacchini, Marco Spagnoli and Giorgio Fusconi, 2016. Performance, Safety and Tissue Residue Study for Coated Sodium Butyrate Added to Broiler Feed. International Journal of Poultry Science, 15: 161-174.

DOI: 10.3923/ijps.2016.161.174

URL: https://scialert.net/abstract/?doi=ijps.2016.161.174

REFERENCES
Bligh, E.G. and W.J. Dyer, 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37: 911-917.
CrossRef  |  PubMed  |  Direct Link  |  

Burdock, G.A., 2010. N-Butyric Acid. In: Fenaroli's Handbook of Flavor Ingredients, Burdock, G.A. (Ed.). 6th Edn., CRC Press, Boca Raton, FL., pages: 223.

Chamba, F., M. Puyalto, A. Ortiz, H. Torrealba, J.J. Mallo and R. Riboty, 2014. Effect of partially protected sodium butyrate on performance, digestive organs, intestinal villi and E. coli development in broilers chickens. Int. J. Poult. Sci., 13: 390-396.
CrossRef  |  Direct Link  |  

Coleman, E.C., C.T. Ho and S.S. Chang, 1981. Isolation and identification of volatile compounds from baked potatoes. J. Agric. Food Chem., 29: 42-48.
CrossRef  |  Direct Link  |  

Cortyl, M., 2014. Sodium butyrate in poultry-the importance of a proper protection. Technical Bulletin No. 16, Norel Animal Nutrition. http://norel.net/en/system/files/tb_16_butyrate_protection_eng_3.pdf.

Czerwinski, J., O. Hojberg, S. Smulikowska, R.M. Engberg and A. Mieczkowska, 2012. Effects of sodium butyrate and salinomycin upon intestinal microbiota, mucosal morphology and performance of broiler chickens. Arch. Anim. Nutr., 66: 102-116.
CrossRef  |  Direct Link  |  

Den Besten, G., K. van Eunen, A.K. Groen, S.K. Venema, D.J. Reijngoud and B.M. Bakker, 2013. The role of short-chain fatty acids in the interplay between diet, gut microbiota and host energy metabolism. J. Lipid Res., 54: 2325-2340.
CrossRef  |  Direct Link  |  

FDA., 2006. General principles for evaluating the safety of compounds used in food-producing animals. Report No. 3, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Veterinary Medicine, July 25, 2006, pp: 1-42.

Guilloteau, P., L. Martin, V. Eeckhaut, R. Ducatelle, R. Zabielski and F. Van Immerseel, 2010. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr. Res. Rev., 23: 366-384.
CrossRef  |  Direct Link  |  

Katz, G.V. and D. Guest, 1994. Aliphatic Carboxylic Acids. In: Patty's Industrial Hygiene and Toxicology, Clayton, G.D. (Ed.), John Wiley & Sons, New York, pp: 3523-3541.

Levy, A.W., J.W. Kessler, L. Fuller, S. Williams, G. F. Mathis, B. Lumpkins and F. Valdez, 2015. Effect of feeding an encapsulated source of butyric acid (ButiPEARL) on the performance of male Cobb broilers reared to 42 d of age. Poult. Sci., 94: 1864-1870.
CrossRef  |  Direct Link  |  

McNeil, N.I., 1984. The contribution of the large intestine to energy supplies in man. Am. J. Clin. Nutr., 39: 338-342.
Direct Link  |  

NRC., 1994. Nutrient Requirements of Poultry. 9th Edn., National Academy Press, Washington, DC., USA., ISBN-13: 9780309048927, Pages: 155.

Opdyke, D.L.J., 1981. n-butyric acid. Food Cosmet. Toxicol., 19: 97-116.
Direct Link  |  

Pontes, H., P.G. de Pinho, S. Casal, H. Carmo and A. Santos et al., 2009. GC determination of acetone, acetaldehyde, ethanol and methanol in biological matrices and cell culture. J. Chromatogr. Sci., 47: 272-278.
CrossRef  |  Direct Link  |  

Smulikowska, S., J. Czerwinski, A. Mieczkowska and J. Jankowiak, 2009. The effect of fat-coated organic acid salts and a feed enzyme on growth performance, nutrient utilization, microflora activity and morphology of the small intestine in broiler chickens. J. Anim. Feed Sci., 18: 478-489.
Direct Link  |  

Van den Borne, J.J.C.G., M.J.W. Heetkamp, J. Buyse and T.A. Niewold, 2015. Fat coating of Ca butyrate results in extended butyrate release in the gastrointestinal tract of broilers. Livestock Sci., 175: 96-100.
CrossRef  |  Direct Link  |  

Von Oettingen, W.F., 1960. The aliphatic acids and their esters: Toxicity and potential dangers. The saturated monobasic acids and their esters: Aliphatic acids with three to eighteen carbons and their esters. Arch. Ind. Health, 21: 100-113.
Direct Link  |  

Yoon, H.R., 2015. Simultaneous determination of plasma lactate, pyruvate and ketone bodies following tert-butyldimethylsilyl derivatization using GC-MS-SIM. Biomed. Sci. Lett., 21: 241-247.
CrossRef  |  Direct Link  |  

Zhang, W.H., Y. Jiang, Q.F. Zhu, F. Gao, S.F. Dai, J. Chen and G.H. Zhou, 2011. Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. Br. Poult. Sci., 52: 292-301.
CrossRef  |  Direct Link  |  

©  2019 Science Alert. All Rights Reserved
Fulltext PDF References Abstract