Mohammad Sharifzadeh
Department of Toxicology and Pharmacology , Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Iran
Mahsa Raoufi
Department of Toxicology and Pharmacology , Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Iran
Amir Abbas Zahedinejad
Department of Toxicology and Pharmacology , Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Iran
Nourollah Aghaebrahimi
Department of E.N.T., Amiralam Hospital, Faculty of Medicine,
Tehran University of Medical Sciences, Tehran, Iran
Kurdistan Sharifzadeh
Department of Toxicology and Pharmacology , Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Iran
Mohammad Abdollahi
Department of Toxicology and Pharmacology , Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Iran
ABSTRACT
The effects of chronic lead acetate treatment on alterations of Auditory Brainstem Response (ABR) induced by gentamicin and amikacin were tested in guinea pigs. This study was designed to investigate the hypothesis that aminoglycoside antibiotics and lead via their effects on phosphoinositide pathway and calcium channels may influence ototoxicity mechanisms as tested on the auditory brainstem response. Intramuscular injection of different doses of gentamicin (5, 10 mg/kg/day) and amikacin (150, 300 mg/kg/day) for three weeks induced hearing loss. Administration of lead acetate (0.05%, 35 days) in drinking water changed ABR (absolute wave latency). The gentamicin-induced alteration of ABR were attenuated by chronic lead acetate pretreatment in guinea pig. Obtained data suggest the interactions between chronic lead acetate and aminoglycoside antibiotics in alterations of auditory functions which could be accounted for, at least partially, by perturbations of the phosphoinositide and calcium cascades within the inner ear.
PDF References
How to cite this article
Mohammad Sharifzadeh, Mahsa Raoufi, Amir Abbas Zahedinejad, Nourollah Aghaebrahimi, Kurdistan Sharifzadeh and Mohammad Abdollahi, 2005. Effects of Chronic Lead Exposure on Aminoglycosides-induced Changes in Guina Pig Auditory Brainstem Responses. International Journal of Pharmacology, 1: 74-78.
DOI: 10.3923/ijp.2005.74.78
URL: https://scialert.net/abstract/?doi=ijp.2005.74.78
DOI: 10.3923/ijp.2005.74.78
URL: https://scialert.net/abstract/?doi=ijp.2005.74.78
REFERENCES
- Verity, M.A., 1990. Comparative observations on inorganic and organic lead neurotoxicity. Environ. Health Perspect., 89: 43-48.
Direct Link - Epstein, H.T., K. Fenton and S. Shimpach, 1991. Lead acetate delays rapid postnatal mouse brain and body growth. Life Sci., 49: 1169-1172.
PubMedDirect Link - Schwartz, J. and D. Otto, 1987. Blood lead, hearing thresholds and neurobehavioral development in children and youth. Arch. Environ. Health, 42: 153-160.
Direct Link - Bellman, S., S. Barnarel and M.A.A. Beagley, 1984. Nine-year review of 841 children tested by transtympanic electrocochleography. J. Laryngol. Otol., 98: 1-9.
PubMedDirect Link - Davis, H., S.K. Hirsh, G.R. Popelka and C. Formby, 1984. Frequency selectivity and thresholds of brief stimuli suitable for electric response audiometry. Audiology, 23: 59-74.
PubMedDirect Link - Yamamura, K., K. Terayama, N. Yamamoto, A. Kohyama and R. Kishi, 1989. Effects of acute lead acetate exposure on adult guinea pigs: Electrophysiological study of the inner ear. Fundam. Applied Toxicol., 13: 509-515.
Direct Link - Molfese, D.L., N.K. Laughlin, P.A. Morse, S.E. Linnville, W.F. Wetzel and R.J. Erwin, 1986. Neuroelectrical correlates of categorial perception for place of articulation in normal and lead-treated rhesus monkeys. J. Clin. Exp. Neuropsychol., 8: 680-696.
Direct Link - Bishop, W.P., J.J. August, J.M. Petrin and J.K. Pai, 1990. Regulation of sn-1, 2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Biochem. J., 269: 465-473.
PubMedDirect Link - Cazals, J., J.M. Aran, J.P. Erre and A. Guilhume, 1980. Acoustic responses after total destruction of the ochlear receptor brainstem and auditory cortex. Science, 210: 83-86.
Direct Link - Ralston, D.M. and T.V. Ohalloran, 1990. Metaloregulatory proteins and molecular mechanisms of heavy metal signal transduction. Adv. Inorganic Biochem., 8: 1-31.
PubMedDirect Link - Tran Ba Huy, P. and D. Deffernnes, 1990. Influence of membrane surface potential and net charge on aminoglycoside binding to the organ of corty of guinea pigs. ORL J. Otorhinolaryngol. Relat Spec, 52: 121-126.
PubMedDirect Link - Schacht, J. and H.P. Zenner, 1987. Evidence that phosphoinositides mediate motility in cochlear outer hair cells. Hear. Res., 31: 155-160.
Direct Link - Au, S., N.D. Weiner and J. Schacht, 1987. Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide containing membrane: A study with carboxy fluorescein in liposomes. Biochem. Biophys. Acta, 902: 80-86.
PubMedDirect Link - Holdstein, Y., H. Pratt, M. Goldsher, G. Rosen, R. Shenhave, S. Linn, A. Mor and A. Barkai, 1986. Auditory brain stem evoked potentials in asymptomatic lead-exposed subjects. J. Laryngol. Otol., 100: 1031-1036.
PubMedDirect Link - Kiss, T. and O.N. Osipenko, 1994. Toxic effects of heavy metals on ionic channels. Pharmacol. Rev., 46: 245-267.
PubMedDirect Link - Sharifzadeh, M., M. Abdollahi, H. Behrooz, B. Amini, A. Kebriaeezadeh, A.R. Dehpour and N. Aghaebrahimi, 1998. Effects of chronic lithium on ototoxicity induced by gentamicin and amikacin in guinea pig. Pharmacol. Toxicol., 83: 220-224.
Direct Link - Abdollahi, M., A.R. Dehpour and H. Rashidi, 1997. Inhibition by lithium of gentamicin-induced release of N-acetyl-beta-D-glucosaminidase in rat submandibular saliva. Gen. Pharmacol., 29: 447-451.
CrossRefDirect Link - Murakami, K., G. Feng and S.G. Chen, 1993. Inhibition of brain protein kinase C subtypes by lead. J. Pharmacol. Exp. Ther., 264: 757-761.
Direct Link - Doroshenko, P.A., P.G. Kostyok and A.E. Martynyuk, 1982. Intracellular metabolism of adenosine 3', 5'-cyclic monophosphate and calcium inward current in perfused neurons of helix pomatia. Neuroscience, 7: 2125-2134.
PubMedDirect Link - Gyori, J., T. Kiss, A.D. Scherbatko, P.V. Belan, A.V. Tepikin, O.N. Osipenko and J. Slinky, 1991. Effect of Ag+ on membrane permeability of perfused helix pomatia neurons. J. Physiol. Lond., 442: 1-13.
PubMedDirect Link - Silbergeld, E.K., 1992. Mechanisms of lead neurotoxicity, or looking beyond the lamppost. FASEB J., 6: 3201-3206.
Direct Link - Ocana, M. and J.M. Baeyens, 1991. Analgesic effects of centrally administered aminoglycoside antibiotics in mice. Neurosci. Lett., 126: 67-70.
PubMedDirect Link