ABSTRACT
The aim of this study was to gas chromatographic analysis of extract of Foeniculum vulgare L. essential oil and to investigate its median lethal dose (LD50) and possible anti-inflammatory effects. The composition of the essential oil was as follows: 74.8% (E)-anethole, 11.1% limonene, 4.7% methyl chavicol, 2.5% fenchone and 1.3% α-pinene. The LD50 dose was found to be 1.038 mL kg-1. The essential oil of Foeniculum vulgare L. was investigated the model of carrageenan induced rat paw edema and it had an anti-inflammatory effect matching to that of etodolac at 0.050 and 0.200 mL kg-1 doses.
PDF References Citation
How to cite this article
Hanefi Ozbek, 2005. The Anti-inflammatory Activity of the Foeniculum vulgare L. Essential Oil and Investigation of its Median Lethal Dose in Rats and Mice. International Journal of Pharmacology, 1: 329-331.
DOI: 10.3923/ijp.2005.329.331
URL: https://scialert.net/abstract/?doi=ijp.2005.329.331
DOI: 10.3923/ijp.2005.329.331
URL: https://scialert.net/abstract/?doi=ijp.2005.329.331
REFERENCES
- Simandi, B., A. Deak, E. Ronyai, G. Yanxiang and T. Veress et al., 1999. Supercritical carbon dioxide extraction and fractionation of fennel oil. J. Agric. Food Chem., 47: 1635-1640.
Direct Link - Ozbek, H., S. Urao, H. Dulger, I. Bayram, G. Tuncer and A. Ozturk, 2003. Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia, 74: 317-319.
CrossRefDirect Link - Forster, H.B., H. Niklas and S. Lutz, 1980. Antispasmodic effects of some medicinal plants. Planta Med., 40: 309-319.
CrossRefDirect Link - Litchfield, Jr. J.T. and F. Wilcoxon, 1949. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther., 96: 99-113.
PubMedDirect Link - Winter, C.A., E.A. Risley and G.W. Nuss, 1962. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Exp. Biol. Med., 111: 544-547.
CrossRefPubMedDirect Link - Rimbau, V., C. Cerdan, R. Vila and J. Iglesias, 1999. Antiinflammatory activity of some extracts from plants used in the traditional medicine of North-African countries. Phytother. Res., 13: 128-132.
PubMedDirect Link - Souza, M.C., A.C. Siani, M.F. Ramos, O.J. Menezes-de-Lima and M.G. Henriques, 2003. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. Pharmazie, 58: 582-586.
PubMedDirect Link