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Broadspectrim, A Novel Antibacterial from Streptomyces sp.

G.H. Shahidi Bonjar , M.H. Fooladi , M.J. Mahdavi and A. Shahghasi

Rapid emergence of antibacterial resistance is well documented as a serious problem worldwide. This situation shows that the potencies of prevalent antibiotics are decreasing steadily. This situation implies the need for searching new antimicrobials to replace with invalidated ones or use in antibiotic rotation programs. In a four years study, from 1,300 soil Actinomycete isolates collected from different localities of Kerman, Hormozgan, Sistan and Baloochestan, south and south east Provinces of Iran, Streptomyces sp. isolate No. 419 showed widest antibacterial activity. The active principle named as Broadspectrim. It showed antibacterial activity against wide range of G+ and G- bacteria as Bacillus anthracis, Bacillus subtilis, Citrobacter diversus, Citrobacter freundii, Corynebacterium diphtheriae, Enterobacter sp., Escherichia coli, Klebsiella pneumoniae, Micrococcus luteum, Proteus vulgaris, Proteus rettgeri, Proteus mirabilis, Proteus morganii, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas syringae pv syringae, Salmonella Para Typhi A, B, C, D, Salmonella typhi, Sarcinia sp., S. marcescens, Shigella dysentery, S. flexneri, S. sonnei, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Vibrio cholera Eltor (INABA) and Xanthomonas sp. but Shigella flexneri and Staphylococcus albus were resistant to it.

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G.H. Shahidi Bonjar , M.H. Fooladi , M.J. Mahdavi and A. Shahghasi , 2004. Broadspectrim, A Novel Antibacterial from Streptomyces sp.. Biotechnology, 3: 126-130.

DOI: 10.3923/biotech.2004.126.130


Acar, J.F. and F.W. Goldstein, 1996. Disk Suscptibility Test. In: Antibiotics in Laboratory Medicine, Lorian V. (Ed.). Williams and Wilkins, A Waverly Co., Baltimore, pp: 1-51.

Archibald, L., L. Phillips and D. Monnet, 1997. Antimicrobial resistance in isolates from inpatients and outpatients in the united states: Increasing importance of the intensive care unit. Clin. Infect. Dis., 24: 211-215.
PubMed  |  

Blanco, J.E., M. Blanco, A. Mora and J. Blanco, 1997. Prevalence of bacterial resistance to quinolones and other antimicrobials among avian Escherichia coli strains isolated from septicemic and healthy chickens in Spain. J. Clin. Microbiol., 35: 2184-2185.
PubMed  |  Direct Link  |  

Boyd, R.F., 1995. Basic Medical Microbiology. 5th Edn., Little, Brown and Co., Boston, pp: 310-314.

Cohen, M.L., 2000. Changing patterns of infectious disease. Nature, 406: 762-767.
Direct Link  |  

Cookson, B.D., 2000. Methicillin-resistant Staphylococcus aureus in the community: New battlefronts, or are the battles lost? Infect. Control Hosp. Epidemiol., 21: 398-403.

Cragg, G.M., D.J. Newman and K.M. Snader, 1997. Natural products in drug discovery and development. J. Nat. Prod., 60: 52-60.
CrossRef  |  PubMed  |  Direct Link  |  

Enne, V.I., D.M. Livermore, P. Stephens and L.M.C. Hall, 2001. Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction. Lancet, 28: 1325-1328.

Fridkin, S.K., H.A. Hill, N.V. Volkava, J.R. Edwards, R.M. Lawton and R.P. Gaynes, 2002. Temporal changes in prevalence of antimicrobial resistance in 23 U.S. hospitals. Emerg. Infect. Dis., 8: 697-700.

Gerding, D.N., T.A. Larson and R.A. Hughes, 1991. Aminoglycoside resistance and aminoglycoside usage: Ten years of experience in one hospital. Antimicrob. Agents Chemother., 35: 1284-1290.
PubMed  |  Direct Link  |  

Gold, H.S. and R.C. Moellering Jr., 1996. Antimicrobial-drug resistance. N. Engl. J. Med., 335: 1445-1453.
CrossRef  |  Direct Link  |  

Grabley, S. and R. Thiericke, 1999. Drug Discovery from Nature. Spinger, London, pp: 51-55.

Gupta, K., D. Scholes and W.E. Stamm, 1999. Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women. J. Am. Med. Assoc., 281: 736-738.
CrossRef  |  Direct Link  |  

Jones, A.M., J.R. Govan, C.J. Doherty, M.E. Dodd, B.J. Isalska, T.N. Stanbridge and A.K. Webb, 2001. Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic. Lancet, 358: 557-558.

Kudo, T., 1997. Family Streptomycetaceae. In: Atlas of Actinomycetes, Miyadoh, S. (Ed.). The Society for Actinomycetes Japan, Asakura Co., Japan, pp: 122-129.

Lee, J.Y. and B.K. Hwang, 2002. Diversity of antifungal actinomycetes in various vegetative soils of Korea. Can. J. Microbiol., 48: 407-417.
Direct Link  |  

Manges, A.R., J.R. Johnson, B. Foxman, T.T. O'Bryan, K.E. Fullerton and L.W. Riley, 2001. Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group. New Engl. J. Med., 345: 1007-1013.
Direct Link  |  

Marchese, A. and G.C. Shito, 2001. Resistance patterns of lower respiratory tract pathogens in Europe. Int. J. Antimicrob. Agents, 16: 25-29.
CrossRef  |  PubMed  |  Direct Link  |  

McCallum, S.J., J. Corkill, M. Gallagher, M.J. Ledson, C.A. Hart and M.J. Walshaw, 2001. Superinfection with transmissible strain of Pseudomonas aeruginosa in adults with cystic fibrosis chronically colonized by P. aeruginosa. Lancet, 358: 558-560.

Miyadoh, S., 1997. Frontispiece. In: Atlas of Actinomycetes, Miyadoh, S. (Ed.). The Society for Actinomycetes Japan, Asakura Co., Japan, pp: 1-5.

Niederman, M.S., 1997. Is crop rotation of antibiotics the solution to a resistant problem in the ICU? Am. J. Respir. Crit. Care Med., 156: 1029-1031.

O'Brien, F.G., J.W. Pearman, M. Gracey, T.V. Riley and W.B. Grubb, 1999. Community strain of methicillin-resistant Staphylococcus aureus involved in a hospital outbreak. J. Clin. Microbiol., 37: 2858-2862.
PubMed  |  Direct Link  |  

Okami, B. and A.K. Hotta, 1988. Search and Discovery of New Antibiotics. In: Actinomycetes in Biotechnology, Goodfellow, M., S.T. Williams and M. Mordarski (Eds.). Pergamon Press, Oxford, pp: 33-67.

Quale, J., D. Landman and E. Atwood, 1996. Experience with a hospital-wide outbreak of vancomycin-resistant enterococci. Am. J. Infect. Control, 24: 372-379.
PubMed  |  Direct Link  |  

Saadoun, I. and R. Gharaibeh, 2002. The Streptomycetes flora of Jordan and its potential as a source of antibiotics active against antibiotic resistant Gram negative bacteria. World J. Microbiol. Biotechnol., 18: 465-470.
Direct Link  |  

Saadoun, I., F. Al-Momani, H. Malkawi and M.J. Mohammad, 1999. Isolation, identification and analysis of antibacterial activity of soil streptomycetes isolates from North Jordan. Microbios, 100: 41-46.
Direct Link  |  

Schroeder, C.M., J. Meng, S. Zhao, C. DebRoy and J. Torcolini et al., 2002. Antimicrobial resistance of Escherichia coli O26, O103, O111, O128 and O145 from animals and humans. Emerg. Infect. Dis., 8: 1409-1414.
PubMed  |  Direct Link  |  

Senda, K., Y. Arakawa, K. Nakashima, H. Ito and S. Ichiyama et al., 1996. Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including Carbapenems. Antimicrob. Agents Chemother., 40: 349-353.

Smith, T.L., M.L. Pearson, K.R. Wilcox, C. Cruz and M.V. Lancaster et al., 1999. Emergence of vancomycin resistance in Staphylococcus aureus. N. Engl. J. Med., 340: 493-501.
Direct Link  |  

Sykes, G. and F.A. Skinner, 1973. Actinomycetales: Characteristics and Practical Importance. Academic Press, London.

WHO, 2001. Strategy for containment of antimicrobial resistance. http:/ antimicrobial_resistance/docs/EGlobal_Strat.pdf.

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