Subscribe Now Subscribe Today
Editorial
 

Antioxidants as an Appropriate Approach to Improve the Outcome of Pancreatic Islet Isolation: Evidences from Animal Studies



Asieh Hosseini and Mohammad Abdollahi
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
ABSTRACT

Not Available.

Services
Related Articles in ASCI
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Asieh Hosseini and Mohammad Abdollahi, 2012. Antioxidants as an Appropriate Approach to Improve the Outcome of Pancreatic Islet Isolation: Evidences from Animal Studies. Asian Journal of Animal and Veterinary Advances, 7: 540-541.

DOI: 10.3923/ajava.2012.540.541

URL: https://scialert.net/abstract/?doi=ajava.2012.540.541
 
Received: October 24, 2011; Accepted: December 28, 2011; Published: February 17, 2012



Diabetes mellitus has become an important disorder with socioeconomic burden and complications worldwide. It is noteworthy that, efficacy or safety of treatments for diabetes is still a concern (Mohseni Salehi Monfared et al., 2009; Salari et al., 2011).

Pancreatic islet transplantation has been reported to be a widespread successful step toward a cure in diabetic patients. Despite recent extensively improvements in islet isolation and transplantation techniques, loss of healthy functional islets are one of the major obstacles to this therapy (Irani et al., 2009). Oxidative stress by imbalance between production and manifestation of reactive oxygen species plays an essential role in cell injury during islet isolation and transplantation procedures. The result of this process is cellular death and β-cell failure. Islet transplantation involves the exposure of islets to several forms of stress, including activation of free radicals, oxidative stress-induced apoptosis as the result of islet isolation and pancreatic preservation (Mohseni Salehi Monfared et al., 2009). Therefore, methods are urgently needed to improve islet resistance to oxidative stress even during diabetes (Rahimi et al., 2005). Antioxidants that act against oxidants include enzymatic and non-enzymatic types. Enzymatic antioxidants include Super Oxide Dismutase (SOD), catalase (CAT) and Glutathion Peroxidase (GPx). Non-enzymatic antioxidants include vitamins like C, E, zinc, uric acid and selenium (Abdollahi et al., 2004).

In the recent years, some antioxidants have been examined on isolated rat Langerhans islets that showed optimistic effects such as facilitating conditions of islet transplantation, improvement of islet cell function before transplantation, improvement of transplant outcome and graft function. These substances include IMOD (Larijani et al., 2011), specific phosphodiesterase inhibitors (Mohammadi et al., 2011), low-level laser irradiation (Irani et al., 2009), calcium channel blockers, autonomic nervous system blockers and free radical scavengers (Pourkhalili et al., 2009), cAMP and cGMP phosphodiesterase inhibitors (Ghafour-Rashidi et al., 2007).

Therefore, the benefits of antioxidants in islet isolation procedures cannot be ignored but studies should be continued. These findings suggest that antioxidants may help facilitate conditions of islet transplantation.

REFERENCES

  1. Abdollahi, M., A. Ranjbar, S. Shadnia, S. Nikfar and A. Rezaie, 2004. Pesticides and oxidative stress: A review. Med. Sci. Monit., 10: RA141-RA147.
    PubMed  |  Direct Link  |  


  2. Ghafour-Rashidi, Z., E. Dermenaki-Farahani, A. Aliahmadi, H. Esmaily, A. Mohammadirad, S.N. Ostad and M. Abdollahi, 2007. Protection by cAMP and cGMP phosphodiesterase inhibitors of diazinon-induced hyperglycemia and oxidative/nitrosative stress in rat langerhans islets cells: Molecular evidence for involvement of non-cholinergic mechanisms. Pestic. Biochem. Physiol., 87: 261-270.
    CrossRef  |  


  3. Irani, S., S.S.M.S. Monfared, M. Akbari-Kamrani, S.N. Ostad, M. Abdollahi and B. Larijani, 2009. Effect of low-level laser irradiation on in vitro function of pancreatic islets. Transplant. Proc., 41: 4313-4315.
    CrossRef  |  


  4. Larijani, B., M. Salimi, N. Pourkhalili, A. Mohammadirad, M. Baeeri, A. Nili-Ahmadabadi and M. Abdollahi, 2011. Positive response of isolated rat pancreatic islets to IMOD; hopes for better transplant outcome and graft function. Asian J. Anim. Vet. Adv., 6: 1019-1025.
    CrossRef  |  Direct Link  |  


  5. Mohammadi, M., S. Atashpour, N. Pourkhalili, A. Nili-Ahmadabadi and M. Baeeri et al., 2011. Comparative improvement in function of isolated rat langerhans islets by various phosphodiesterase 3, 4 and 5 inhibitors. Asian J. Anim. Vet. Adv., 6: 1233-1240.
    CrossRef  |  


  6. Monfared, S.S.M.S., B. Larijani and M. Abdollahi, 2009. Islet transplantation and antioxidant management: A systematic review. World J. Gastroenterol., 15: 1153-1161.
    CrossRef  |  PubMed  |  Direct Link  |  


  7. Pourkhalili, N., S. Pournourmohammadi, F. Rahimi, S. Vosough-Ghanbari, M. Baeeri, S.N. Ostad and M. Abdollahi, 2009. Comparative effects of calcium channel blockers, autonomic nervous system blockers and free radical scavengers on diazinon-induced hyposecretion of insulin from isolated islets of Langerhans in rats. Arh. Hig. Rada. Toksikol., 60: 157-164.
    PubMed  |  


  8. Rahimi, R., S. Nikfar, B. Larijani and M. Abdollahi, 2005. A review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother., 59: 365-373.
    PubMed  |  Direct Link  |  


  9. Salari, P., S. Nikfar and M. Abdollahi, 2011. No superiority of exenatide over insulin in diabetic patients in terms of weight reduction or incidence of adverse effects: A meta-analysis. Int. J. Pharmacol., 7: 749-756.
    CrossRef  |  Direct Link  |  


©  2022 Science Alert. All Rights Reserved