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    Publisher: Science Alert
   
  Singapore Journal of Scientific Research is a quarterly, peer-reviewed international research journal that addresses both applied and theoretical issues. The scope of the journal encompasses research articles, original research reports, reviews, short communications and scientific commentaries in the fields of applied and theoretical sciences, biology, chemistry, physics, zoology, medical studies, environmental sciences, mathematics, statistics, geology, engineering, agricultural engineering, computer science, social sciences, natural sciences, technological sciences, linguistics, medicine, industrial and all other applied and theoretical sciences.

Singapore Journal of Scientific Research now accepting new submissions. Submit your best paper via online submission system.
  Editor-in-Chief:  Anmol Mathur
 
 
Alagarsamy, V., B. Narendhar, M.T. Sulthana and V.R. Solomon, 2014. Design and synthesis of 3-(4-chlorophenyl)-2-(2-(4-substituted)-2-oxoethylthio) quinazolin-4 (3H)-one as antihistamine agents. Med. Chem. Res., 23: 4692-4699.
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Alagarsamy, V., B.A. Kumar, P. Parthiban, R.V. Sheorey and V.R. Solomon, 2012. Synthesis and antibacterial activity of some novel 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides. Anti-infective Agents. 10: 105-110.
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Alagarsamy, V., D. Shankar, V.R. Solomon, 2006. Synthesis of some novel 2-Mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-inflammatory agents. ARIKVOC, 16: 149-159.
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Alagarsamy, V., D. Shankar, V.R. Solomon. R.V. Sheorey and P. Parthiban, 2009. Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agent. Acta Pharm., 59: 75-88.
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Alagarsamy, V., H.K. Sharma, P. Parthiban, J.C.H. Singh, S.T. Murugan and V.R. Solomon, 2009. 4-(3-Methoxyphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones: New class of H1-Antihistaminic agents veerachamy alagarsamy. Pharmazie, 64: 5-9.
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Alagarsamy, V., K. Kavitha, M. Rupeshkumar, V.R. Solomon, D.S. kumar, 2009. Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. Acta Pharm., 59: 97-106.
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Alagarsamy, V., P. Parthiban, V.R. Solomon, K. Dhanabal, S. Murugesan, G. Saravanan and G.V. Anjana, 2008. Synthesis and pharmacological investigation of novel 4-(4-ethyl phenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. J. Heterocyclic Chem., 45: 709-715.
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Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon and T.D. Kumar, 2007. 4-Cyclohexyl-1-substituted-4H-[1,2,4]triazolo [4,3-a] quinazolin-5-ones: Novel Class of H1-antihistaminic agents. Chem. Biol. Drug Des., 70: 158-163.
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Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon, T.D. Kumar and K. Thirumurugan, 2007. Synthesis of novel 3-Butyl-2-Substituted Amino-3H-Quinazolin-4-ones as analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 70: 254-260.
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Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon and K. Thirumurugan, 2008. Synthesis, analgesic, anti-inflammatory and ulcerogenic index activities of novel 2-methylthio-3-substituted-5,6-dimethyl thieno [2,3-d] pyrimidin-4(3H)-ones. Drug Develop. Res., 69: 226-233.
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Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon, K. Thirumurugan, K. Dhanabal and M. Murugan, 2006. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones. Eur. J. Med. Chem., 41: 1293-1300.
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Alagarsamy, V., S. Vijayakumar and V.R. Solomon, 2007. Synthesis of 2-Mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, Anti-inflammatory agents. Biomed. Pharmacotherapy, 61: 285-291.
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Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V. Raja Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-Subtituted thiadiazolo quinazolines. Indian J. Pharmac. Sci., 65: 293-296.
Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V.R. Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-substituted thiadiazolo quinazolines. Indian J. Pharm. Sci., 65: 293-296.
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Alagarsamy, V., U.S. Pathak, V.R. Solomon, S. Meena, K.V. Rameshu and R. Rajesh, 2004. Anticancer, antibacterial and antifungal activites of some 2-substituted (1,3,4) thiadiazolo (2,3-b) tetrahydrobenzo (b) thieno (3,2-e) pyrimidines. Indian J. Heterocycl. Chem., 13: 347-350.
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Alagarsamy, V., V.R. Solomon and K. Dhanabal, 2007. Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-ones as analgesic, anti-inflammatory agents. Bioorg. Med. Chem., 15: 235-241.
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Alagarsamy, V., V.R. Solomon and M. Murugan, 2007. Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents. Bioorg. Med. Chem., 15: 4009-4015.
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Alagarsamy, V., V.R. Solomon and S. Murugesan, 2008. Synthesis and pharmacological evaluation of some 3-(2-Methylphenyl)-2-Substituted amino-quinazolin-4(3H)-ones as analgesic and Anti-inflammatory agents. Arzneimittelforschung-Drug Res., 58: 174-181.
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Alagarsamy, V., V.R. Solomon, G. Deepa, P. Parthiban and G.V. Anjana, 2007. Synthesis and pharmacological investigation of 3-Subsituted-amino-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-Inflammatory agents. Arch. Pharm., 340: 352-358.
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Alagarsamy, V., V.R. Solomon, G.V. Kavitha, V. Paluchamy and M.R. Chandran et al., 2002. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Phenyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 25: 1432-1435.
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Alagarsamy, V., V.R. Solomon, M. Murugan, K. Dhanabal, P. Parthiban and G.V. Anjana, 2008. Design and synthesis of 3-(4-Ethylphenyl)-2-substitutedamino-3H-quinazolin-4-ones as novel class of analgesic and Anti-inflammatory agents. J. Enzyme Inhib. Med. Chem., 23: 839-847.
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Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2010. Synthesis and analgesic, Anti-inflammatory activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., (In Press) 10.1007/s00044-010-9417-z.
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Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2011. Synthesis and Analgesic, Anti-inflammatory Activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., 20: 946-954.
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Alagarsamy, V., V.R. Solomon, R. Meena and K.V. Ramseshu, 2005. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Butyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 28: 1091-1094.
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Alagarsamy, V., V.R. Solomon, R. Meena, K.V. Ramaseshu, K. Thirumurugan and S. Murugesan, 2007. Design and synthesis of 2-Methylthio-3-substituted-5,6-dimethylthieno [2,3-d] pyrimidin-4(3H)-ones as analgesic Anti-Inflammatory and antibacterial agents. Med. Chem., 3: 67-73.
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Alagarsamy, V., V.R. Solomon, R. Sankaranarayanan, P. Periyasamy, R. Deepa and T.D. Anandkumar, 2008. Synthesis of 3-(2-pyridyl)-2-Substituted-quinazolin-4(3H)-ones as new analgesic and Anti-inflammatory agents. Biomed. Pharmacother, 62: 454-461.
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Alagarsamy, V., V.R. Solomon, R.V. Sheorey. R. Jayakumar, 2009. Synthesis of 3-(3-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as novel class of Analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 73: 471-479.
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Desphande, S., Solomon, V.R., S.B. Katti and Y.S. Prabhakar, 2009. Topological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype. J. Enzyme Inhib. Med. Chem., 24: 94-104.
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Gokulan, P.D., B. Jayakar and V. Alagarsamy and V.R. Solomon, 2012. Synthesis and pharmacological investigation of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters as new analgesic and anti-inflammatory agents. Arzneim.Forsch. .
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Hu, C., V.R. Solomon, G. Ulibarri and H. Lee, 2008. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg. Med. Chem., 16: 7888-7893.
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Hu, C., V.R. Solomon, P. Cano and H. Lee, 2010. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur. J. Med. Chem., 45: 705-709.
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Kadri, D., A.K. Crater, H. Lee, V.R. Solomon and S. Ananvoranich, 2014. The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection. Exp. Parasitol., 145: 135-144.
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Patel, K., C. Karthikeyan, N.S.H.N. Moorthy, G.S. Deora, V.R. Solomon, H. Lee and P. Trivedi, 2012. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents. Med. Chem. Res., 21: 1780-1784.
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Patel, K., C. Karthikeyan, V.R. Solomon, N.S.H.N. Moorthy and H. Lee et al., 2011. Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines. Lett. Drug Des. Discov., 8: 308-311.
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Prabakar, Y.S., V.R. Solomon, R.K. Rawal, M.K.Gupta and S.B. Katti, 2004. CP-MLR/PLS directed structure activtity molecular modeling of the HIV-1 RT inhibitory activity of 2,3-Diaryl-1,3-thiazolidin-4-ones. QSAR Comb. Sci., 23: 234-244.
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Prabhakar, Y.S., R.K. Rawal, M.K. Gupta, V.R. Solomon and S.B. Katti, 2005. Topological descriptors in modeling the HIV-RT inhibitory activityof 2-aryl-3-pyridyl-thiazolidin-4-one. Combinatorial Chem. High-Throughput Screening, 8: 431-437.
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Rawal, R.K., V.R. Solomon, Y.S. Prabhakar, S.B. Katti and E. De Clercq, 2005. Synthesis and QSAR studies on thiazolidinones as HIV-RT inhibitors. Combinatorial Chem. High-throughput Screening, 8: 439-443.
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Senthilraja, M., V. Alagarsamy and V.R. Solomon, 2012. 2,3-disubtituted thiazolidin-4-ones: Novel class of anticonvulsant agents. Lett. Drug Des. Discov., 9: 731-735.
Solomon, V.R. and H. Lee, 2009. Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharm., 625: 220-223.
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Solomon, V.R. and H. Lee, 2011. Quinoline is a privileged scaffold for cancer drug discovery. Curr. Med. Chem., 18: 1488-1508.
Solomon, V.R. and H. Lee, 2012. Anti-breast cancer activity of heteroaryl chalcone derivatives. Biomed. Pharmacother., 66: 213-220.
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Solomon, V.R. and S.C. Chaturvedi, 2003. Analysis of a series of new pyrazolidine-3,5-diones as selective AT1 angiotensin Ii receptor antagonists. Indian Pharm., 15: 53-58.
Solomon, V.R., C. Hu adn H. Lee, 2010. Design and synthesis of CQ analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
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Solomon, V.R., C. Hu and H. Lee, 2009. Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. Bioorg. Med. Chem., 17: 7585-7592.
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Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach. Bioorganic Med. Chem., 18: 1563-1572.
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Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of chloroquine analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
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Solomon, V.R., R.K. Sharma and S.C. Chaturvedi, 2002. Angiotensin antagonist: As antihypertensive agents. Indian Pharm., 1: 6-8.
Solomon, V.R., S.K. Puri, K. Srivastava and S.B. Katti, 2005. Design and synthesis of new antimalarial agents from 4-aminoquinoline. Bioorg. Med. Chem., 13: 2157-2165.
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Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri and S.B. Katti, 2012. Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. J. Enzyme Inhib. Med. Chem. .
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Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri, S.B. Katti, 2012. Design, Synthesis of 4-aminoquinoline derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies. J. Enzyme Inhib. Med. Chem. 10.3109/14756366.2012.666537.
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Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S. Rajakumar, S.K. Puri and S.B. Katti, 2008. Synthesis and antimalarial activity of novel side chain modified antimalarial agents from 4-aminoquinoline. Med. Chem., 4: 446-451.
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Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S.K. Puri and S.B. Katti, 2010. 4-Aminoquinoline derived antimalarials: Synthesis and heme polymerization inhibition studies. Eur. J. Med. Chem., 45: 4990-4996.
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Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2006. Design, synthesis and antimalarial activity of a new class of iron chelators. Med. Chem., 2: 1-6.
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Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2007. Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J. Med. Chem., 50: 394-398.
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Solomon, V.R., and S.C. Chaturvedi, 2004. QSAR Studies of diphenylpropionic acids based selective AT1 angiotensin II receptor antagonist as antihypertensive agents. Indian J. Heterocycl. Chem., 13: 373-396.
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Zhang, H., V.R. Solomon, C. Hu, G. Ulibarri and H. Lee, 2008. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed. Pharmacotherapy, 62: 65-69.
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