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Articles by Zheng Chen
Total Records ( 7 ) for Zheng Chen
  Zheng Chen , Xiao-bing Zou , Ya-nan Zhang , Xin-ming Son , Chun-non Huang and Damu Tang
  Autism is a neurodevelopmental disorder defined by impairments in social interaction, communication, as well as restricted and stereotyped behaviors. While the etiology of autism remains largely unknown, the existence of genetic components has been clearly demonstrated in autistic pathogenesis. The incidence of autism is 50-100 fold greater in the population with autistic family history than the general population. Chromosomal abnormalities in 15q11-13 and 7q22-32 regions have been frequently detected in autistic patients. Abnormalities in other chromosomal regions, including 14q32.3 deletion and t(5;18)(q33.1;q12.1) translocation, have also been reported. Despite these progresses, the exact genetic changes which underlie the disorder remain elusive. We report here two novel chromosomal abnormalities, an inversion inv(5)(p13;q13) and a translocation t(7;18)(q32;q21) in two autistic children. These findings may help to identify the candidate genes, whose aberrations may contribute to autistic pathogenesis.
  Zhuguo Li , Zheng Chen , Peng Zeng and Kaicheng Wu
  Online games are receiving more and more attention due to the potential market. But how to implement information dissemination reliably and efficiently in gaming platform along with large or larger size of game users is urgent to be solved. Peer-to-peer (P2P) technology becomes more and more popular because it can massively reduce loads on backbone of Internet, pushing intelligence to the edge of Internet. Nowadays, P2P is turning towards hybrid model which integrates advantages of central model with fully distributed model. Hybrid model is also called a semi-structured model which considers the difference among peers. Peers are often divided into two branches, superpeer group and leafpeer group. Superpeers are often to designate more important tasks. It’s widely applied in streaming, storage and IM etc. But how to disseminate messages on hybrid P2P reliably and efficiently is an open issue. Previous works often take tree-based multicast or flat probability model which cannot make a trade-off in reliability and efficiency. Doualcast, a probability information dissemination model on hybrid P2P system, is presented in this paper which considers ability among peers and can select suitable peer to forward messages, improving reliability of multicast. Simulations demonstrate DouLaCast functions better than flat gossip method.
  Zheng Chen , Chong Peng and Long Qin
  Packet dropout and retransmission have become a more and more serious problem in high delay-bandwidth network, it is difficult for traditional streaming compression to deal with reorder packets, people have to use stateless compression, but it can only achieve very low compression ratio. In this study, we introduce a novel Orderless Tolerance Compression Algorithm (OTCA). The algorithm works effectively with orderless packets which is caused by the packet retransmission, through allowing variable delay in the dictionary construction. OTCA performs better compression ratio than stateless compression and low decoding latency than that of streaming compression and excels delay-dictionary compression in both compression ratio and decoding latency especially in high bandwidth network. We conduct extensive experiments to establish the potential improvement for packet compression techniques, using many data files including the Calgary corpus and the Canterbury corpus. Experimental results of the OTCA show that it is a good compromise proposal for transfer massive data over high delay-bandwidth networks.
  Zheng Chen , Hao Zhengli , Li Fadi , Guo Yanli and Jin Yanmei
  This study was conducted to investigate the effects of adding Mannan-Oligosaccharide (MOS) to different concentrate-to-roughage diets on ruminal fermentation in vitro. A 4x6 two factorial experimental design (the concentrate-to-roughage ratio, 20:80, 30:70, 40:60, 50:50 and the MOS level, 0, 0.4, 0.8, 1.2, 1.6 and 2.0%) was carried out. The gas production technique was adopted and used the 100 mL cultivated bottles, 50 mL graduated syringes and thermostatic water bath pans as in vitro cultivated device. The in vitro incubation continued 24 h and collected samples at 3, 6, 9, 12 and 24 h. Each treatment executed five replicates at each fermentation time. The results showed the gas and methane production were not impacted by concentrate-to-roughage and MOS and the combination of two factors did not influence all items significantly (p>0.05). The In vitro Dry Matter Digestibility (IVDMD) was impacted by concentrate-to-roughage ratio (20:80<40:60, 9 and 12 h, p<0.05, 24 h, p<0.01; 20:80<50:50, 3, 12 and 24 h, p<0.01). The In vitro Crude Protein Digestibility (IVCPD) was affected by both concentrate-to-roughage ratio (20:80>40:60, 3 h, p<0.05; 20:80>50:50, 12 h, p<0.01; 30:70>40:60, 3 h, p<0.01, 6 h, p<0.05; 30:70>50:50, 3 and 12 h, p<0.01; 6 and 9 h, p<0.05) and MOS (0<1.6%, 24 h, p<0.01; 0<2.0%, 24 h, p<0.05). The pH also influenced by concentrate-to-roughage ratio (50:50<20:80, 3, 6, 9 and 12 h, p<0.01; 50:50<30:70, 3, 6 and 12 h, p<0.01; 50:50<40:60, 12 h, p<0.05; 20:80>40:60, 6 and 12 h, p<0.01; 3 and 9 h, p<0.05) and MOS (0>1.6%, 6 and 12 h, p<0.01; 0>2.0%, 6, 12 and 24 h, p<0.05; 0.4>2.0%, 6 h, p<0.05). The NH3-N content was affected by concentrate-to-roughage ratio (50:50<20:80, 3 and 9 h, p<0.05; 50:50<30:70, 12 h, p<0.01) and MOS (2.0>0%, 24 h, p<0.01). The concentrate-to-roughage impacted the ratio of acetic acid to propionic acid (20:80>50:50, p<0.05), acetic acid to TVFAs (20:80>40:60 and 20:80>50:50, p<0.01) and butyric acid to TVFAs (20:80<40:60 and 20:80<50:50, p<0.05). We could find the IVCPD, pH, NH3-N content increased with the reducing of concentrate approximately while opposite to the IVDMD and the IVCPD and NH3-N content increased with the rising of MOS roughly while opposite to pH.
  Zhang Junxia , Zheng Chen , Hou Shengzhen , Li Fadi and Ma Liaowei
  The study was evaluated the effects of dietary energy levels on ruminal fluid parameters in Tibetan ewes. Tibetan ewes with similar weight, age, pregnant period and after delivering were assigned to three dietary treatments (Digestion Energy (DE) levels: 13.00, 13.50, 14.00 MJ kg-1) and pasturing group as control. After 60 days of experimental treatments, 14 sheep were selected rationally and ruminal fluid were collected to determine the content of Volatile Fatty Acid (VFA), pH, the concentrate of ammonia Nitrogen (NH3-N), urea N, protein N and total N of ruminal fluid. The results showed that concentration of TVFAs in ruminal fluid with higher DE than that of control group (p<0.05), meanwhile, TVFA concentration differed at every treatment group (p<0.05). Acetic/propionic, acetic, propionic, delphinic acid of treatments significantly differed with control groups (p<0.05) but no difference between each treatment group, butyric and pentanoic acid were not difference among all groups (p<0.05). Supplemental concentration might improve total N and protein N while different energy level did not affect total N significantly (p>0.05). Compared to pasturing group, the ewes’ supplementations with different energy levels did not significantly affect pH and the relative abundance of total N, NH3-N, urea N and protein N (p>0.05).
  Martine Aubert , Zheng Chen , Robin Lang , Chung H. Dang , Carla Fowler , Derek D. Sloan and Keith R. Jerome
  The Us5 gene of herpes simplex virus (HSV) encodes glycoprotein J (gJ). The only previously reported function of gJ was its ability to inhibit apoptosis. However, the mechanism by which gJ prevents apoptosis is not understood, and it is not known whether gJ mediates additional cellular effects. In this study, we evaluated the expression, localization, and cellular effects of Us5/gJ. Us5 was first expressed 4 h after infection. gJ was detectable at 6 h and was expressed in glycosylated and unglycosylated forms. Us5 was regulated as a late gene, with partial dependency on DNA replication for expression. Us5 expression was delayed in the absence of ICP22; furthermore, expression of Us5 in trans protected cells from apoptosis induced by an HSV mutant with deletion of ICP27, suggesting that the antiapoptotic effects of ICP22 and ICP27 are mediated in part through effects on gJ expression. Within HSV-infected or Us5-transfected cells, gJ was distributed widely, especially to the endoplasmic reticulum, trans-Golgi network, and early endosomes. gJ interacted with FoF1 ATP synthase subunit 6 by a yeast two-hybrid screen and had strong antiapoptotic effects, which were mediated by protein rather than mRNA. Antiapoptotic activity required the extracellular and transmembrane domains of gJ, but not the intracellular domain. Consistent with inhibition of FoF1 ATP synthase function, Us5 was required for HSV-induced reactive oxygen species (ROS) formation, and gJ was sufficient to induce ROS in Us5-transfected cells. Thus, HSV gJ is a multifunctional protein, modulating other cellular processes in addition to inhibition of apoptosis.
  Cristiano Bertolucci , Nicola Cavallari , Ilaria Colognesi , Jacopo Aguzzi , Zheng Chen , Pierpaolo Caruso , Augusto Foa , Gianluca Tosini , Francesco Bernardi and Mirko Pinotti
  The mechanisms underlying the circadian control of gene expression in peripheral tissues and influencing many biological pathways are poorly defined. Factor VII (FVII), the protease triggering blood coagulation, represents a valuable model to address this issue in liver since its plasma levels oscillate in a circadian manner and its promoter contains E-boxes, which are putative DNA-binding sites for CLOCK-BMAL1 and NPAS2-BMAL1 heterodimers and hallmarks of circadian regulation. The peaks of FVII mRNA levels in livers of wild-type mice preceded those in plasma, indicating a transcriptional regulation, and were abolished in Clock–/–; Npas2–/– mice, thus demonstrating a role for CLOCK and NPAS2 circadian transcription factors. The investigation of Npas2–/– and ClockΔ1919 mice, which express functionally defective heterodimers, revealed robust rhythms of FVII expression in both animal models, suggesting a redundant role for NPAS2 and CLOCK. The molecular bases of these observations were established through reporter gene assays. FVII transactivation activities of the NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers were (i) comparable (a fourfold increase), (ii) dampened by the negative circadian regulators PER2 and CRY1, and (iii) abolished upon E-box mutagenesis. Our data provide the first evidence in peripheral oscillators for an overlapping role of CLOCK and NPAS2 in the regulation of circadianly controlled genes.
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