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Articles by Zarina Arif
Total Records ( 2 ) for Zarina Arif
  Mohammed A. Alsaif , Latifa K. Khan , Adel A.H. Alhamdan , Saada M. Alorf , Sawsan H. Harfi , Abdulaziz M. Al-Othman and Zarina Arif
  The aim of present study to evaluate the effect of dates, gahwa and their combination on lipid metabolism in hypercholesterolemic hamsters. The increase intake of dates and gahwa (Arabian coffee) along with a high cholesterol diet in Saudi population as well as increased incidence of cardiovascular disease (CVD) has raised a concern about the effects of the Saudi diet on CVD risk. Golden Syrian hamsters were divided into six groups (six animals in each) as follows: 1) control (chow), 2) Dates-diet (50% date pulp with chow), 3) Dates-diet + gahwa (replaced with drinking water), 4) cholesterol-diet (1% cholesterol in chow), 5) dates-diet + 1% cholesterol, 6) Dates-diet + gahwa + 1% cholesterol. All the above dietary preparations were made every week and supplemented for 13 consecutive weeks. Plasma lipid profile including total cholesterol, triglycerides (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) were estimated. Total cholesterol and TC were estimated in liver, heart and kidney tissues. The high cholesterol-diet caused significant increase in body and organs (liver and kidney) weights as compared to controls. Dates-diet, significantly reduced the body and liver weight that increased by the high cholesterol-diet. Plasma lipids were significantly elevated by high cholesterol-diet supplementation and this increase was significantly decreased by the dates-diet. However, hepatic TC levels further increased when dates were combined with high cholesterol-diet supplementation. Gahwa intake either with dates alone or with high cholesterol-diet was not induced any significant changes in lipid parameters. In conclusion, the dates lowering effects on body weights and plasma lipid profile shows its beneficial affects against atherosclerosis development in humans. Further investigations required for find out its potential constituents that affecting the CVD risk.
  Abdulaziz M. Al-Othman , Fasih Ahmad , Saada Al-Orf , Khalid S. Al-Murshed and Zarina Arif
  In the present study Nigella sativa and Ellataria cardamomum seeds have been studied as inhibitors of oxidative stress caused by oxidized corn oil (having PV 389.8 meq kg-1) in rats. The 70 days feeding male albino rats with experimental diets did not produce significant changes in the body weights, organ weights and food intake of different groups. Increased lipooxidative damage was noticed in oxidized oil fed rats. Oxidized oil diet supplemented with cardamom or N. sativa had marked reduction in RBC hemolysis and plasma AST/ALT activity. The formation of thiobarbituric acid reactive substances were lowest in rats fed N. sativa supplemented diet. Reduced glutathione of liver and kidney were significantly raised after the addition of cardamom/N. sativa to the diets compared to oxidized oil fed rats (Group F). But heart reduced glutathione showed a significant increase as compared to oxidized oil fed group only after the supplementation of N. sativa to the diet. These data indicates that N. sativa or cardamom supplementation improves the overall antioxidant protection capacity of the body.
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