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Articles by Yahya S. Al-Awthan
Total Records ( 2 ) for Yahya S. Al-Awthan
  Yahya S. Al-Awthan , Mohamed A. Al-Douis , Gamal H. El-Sokkary and Esam M. Aqlan
  Dimethoate (DM), an organophosphate insecticide, has been used worldwide in agriculture and domestic for several years which has led to a variety of negative effects in non target species including humans. Therefore, the present study investigated the ameliorative properties of vitamin C (vitC) and E (vitE) on DM toxicity of guinea pigs. The animal groups were orally administered with either vehicle, vitC (200 mg kg-1 body weight) and vitE (200 mg kg-1 body weight), 1/50 LD50 of DM (7 mg kg-1 b.w.) and 1/50 LD50 of DM + vitC and vitE daily for 28 days. Administration of DM resulted in a significant increase in the levels of various serum marker enzymes (AST ALT and ALP). Similarly, significant increase in Lipid Peroxidation (LPO) level while induced significant decreases in the activities of liver Catalase (CAT) and Glutathione-S-Transferase (GST). In contrast, co-administration of vitC and vitE to DM-treated animals restored most of these biochemical parameters to nearly normal levels. Also, DM induced histopathological alterations such as cytoplasmic vacuolization and degeneration in nuclei, congestion, an enlargement of the blood vessels and lymphocytes infiltration in the liver. These changes were ameliorated by vitamins co-administration. The results showed that co-treatment of vitE and vitC protected guinea pigs from DM-induced biochemical and histopathological changes.
  Yahya S. Al-Awthan , Samira M. Hezabr , Aisha M. Al-Zubairi and Faten A. Al-Hemiri
  Organophosphorus (OP) insecticides constitute one of the most widely used classes of pesticides being employed for both agricultural and landscape pest control. The purpose of this study was to investigate the effect of dimethoate (DM), an organophosphorus insecticide, on some biochemical and histopathological parameters in liver of adult male guinea pigs as well as the possible role of Withania somnifera extract in attenuation of DM-induced hepatotoxicity. The animals were divided randomly into 5 groups and kept at 5 animals per group in an environmentally controlled condition with free access to food and water ad libitum. The first group was served as a control group and administered with olive oil orally; the group II received aqueous extract of W. somnifera (100 mg kg-1 b.wt.) orally, group III, IV and V was administered with DM (14 mg kg-1; 1/25LD50) for 21 days orally. Group IV and V received 100 mg kg-1 of W. somnifera extract and silymarin, respectively half hour before DM administration for 21 days. DM caused a statistically significant increase in the serum level of liver enzymes (AST, ALT, ALP) when compared to control animals, whereas, W. somnifera and silymarin pre-treatment to the DM-intoxicated animals resulted in a significant normalization of the enzymes activities. On the other hand W. somnifera extract reduced the incidence of histopathological changes such as cytoplasmic vacuolization and degeneration in nuclei, rupture of epithelia lining the central vein, widened sinusoidal space and lymphocyte infiltration induced by DM treatment in guinea pigs. In conclusion, the results of this study suggest that W. somnifera aqueous extract could protect the liver against DM-induced oxidative damage.
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