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Articles by Y. Raji
Total Records ( 4 ) for Y. Raji
  Y. Raji , Olufadekemi T. Kunle-Alabi , S.B. Olaleye , M.A. Gbadegesin , F.O. Awobajo , O.A. Osonuga , A.O Odukanmi , S.A Salami and Adeyombo F. Bolarinwa
  Antimicrobial drugs have been reported to have adverse effects on male fertility. The present study reports the role of α- tocopherol on metronidazole and tetracycline induced reproductive alterations in albino rats. Male albino rats (5/group) were treated with 20 mg kg-1 bw day-1 metronidazole or 60 mg kg-1 day-1 tetracycline with or without 15 mg kg-1 bw α-tocopherol for 8 weeks. The reversibility of effects after 4 weeks recovery period was determined in separate groups of 5 rats. The control groups received distilled water (vehicle) and 15 mg kg-1 day-1 α- tocopherol for 8 weeks. Metronidazole and tetracycline significantly (p<0.05) reduced the weight of the epididymis, sperm count, motility and serum testosterone levels and increased the activity of endogenous superoxide dismutase (SOD) in the testis. Alpha-tocopherol significantly (p<0.05) decreased the weight of the testis, epididymis, sperm motility and serum testosterone levels. Co-administration of metronidazole or tetracycline with α-tocopherol caused significant restoration in sperm indices and SOD activity while it produced no effect on testosterone secretion. The results suggest that the effects of metronidazole and tetracycline on male reproductive functions, which are partially reversible, could be mediated via a reduction in serum testosterone level and probably also via the free radical generating mechanism.
  Y. Raji , A.O. Morakinyo , A.K. Oloyo , O.S. Akinsomisoye , Olufadekemi , T. Kunle-Alabi , P.R.C. Esegbue-Peters and F.O. Awobajo
  The impact of oral administration of 100 mg kg 1 b.w of chloroform extract of Carica papaya seed (CPE) on oestrous cycle, fertility and serum 17 -oestradiol levels, in female rats was investigated. Ten proestrous rats received 2.5% tween 80 in normal saline (vehicle for CPE) and served as the control in each part of the study. In the oestrous cycle study, ten proestrous rats were treated with CPE for 14 days. The phases and frequencies of the oestrous cycles of the rats were determined daily for another 14 days while CPE treatment continued. In the fertility study, ten proestrous rats were treated as in the oestrous cycle study for 14 days and were thereafter cohabited with fertile untreated male rats for another 14 days while CPE treatment lasted. CPE did not adversely affect body weight of the rats. However there was a significant decrease (p<0.05) in the weight of the ovary, but not in the uterus. There was a significant decrease (p<0.01) in serum 17 -oestradiol levels in CPE treated rats. The oestrous cycle became irregular, with prolonged diestrous phase from the 3rd week of CPE treatment. There were disorganization and degeneration in the ovary. The uterus showed signs of vacuolation and mild disorganization. The extract treated rats produced a significant decrease in litter number (p<0.01) but the fetal weight and morphology remain unchanged relative to the control. The results suggest that chloroform extract of Carica papaya seed has antifertility properties, possibly acting via inhibition of oestrogen secretion.
  Y. Raji , I.O. Osonuga , O.S. Akinsomisoye , O.A. Osonuga and O.O. Mewoyeka
  Male Wister albino rats were exposed to artemether by gavage at dosages of 25, 50 and 75 mg kg-1 day-1 for 1, 2 and 3 days. The control groups received sterile water (control 1) and 5% ethanol (vehicle for artemether, control 2). The maximum volume injected in all groups was 0.5 mL. Rats administered the highest dose for three days were mated with female rats to determine the fertilizing capacity of their epididymal sperms and fertility status. Artemether significantly reduced (p<0.05) the progressive sperm motility, viability, sperm count and serum testosterone levels in dose and duration dependent manners, factors that may impair fertility. None of the untreated cohabited female rats got pregnant throughout the period of the study. These changes were restored in recovery experiments. The results suggest that artemether could induce reversible infertility in rats.
  A.O. Afolabi , V.O. Mabayoje , V.A. Togun , A.S. Oyadeyi and Y. Raji
  The study was designed to compare the relative performance of students admitted into the Medical Programme through Pre-degree Science with those of students admitted through the Joint Admissions and Matriculation Board (JAMB). The performance indices used were the University 100 level Cumulative Grade Point Average (CGPA) and Physiology examination score during the 200 level Comprehensive Examination. The files of students admitted into the Medical Programme in 1998/1999, 1999/2000 and 2000/2001 Sessions were obtained from the Faculty of Basic Medical Sciences. The following data were extracted from each file-age, sex, school certificate result, mode of entry (JAMB, Pre-degree, Direct at 100 level or transfer at 200 level), 100 level CGPA and Physiology score in the 200 level Comprehensive examinations. The study showed that the students admitted through JAMB performed better in 200 level Physiology examinations but there was no correlation between the University Matriculation Examination (UME) Scores and the O-Level aggregate, 100 level CGPA and 200 level Physiology results. The Pre-degree examination score however showed a strong positive correlation with the O-Level aggregate, 100 level CGPA and the 200 level Physiology examination scores. It is therefore recommended that the Pre-degree examination results be used in admitting students into Medicine, as it is a more reliable predictor of success in Medical School Examinations.
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