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Articles by Y. Baimark
Total Records ( 6 ) for Y. Baimark
  N. Niamsa and Y. Baimark
  Highly flexible chitosan films were prepared by film casting of chitosan solutions by using lactic acid solutions as the solvents compare to acetic acid solution. Influences of chitosan molecular weights (100 and 740 kDa), lactic acid concentrations (1.0, 1.5 and 2.0% w/v) and lactic acid configurations (L- and DL-forms) on film characteristics were investigated. Fourier transform infrared (FTIR) spectra of the films showed that there were intermolecular bonds between chitosan film matrices and lactic acids. Tensile strengths at break of the films decreased and percent elongations increased when the lactic acid was used instead of acetic acid for dissolving chitosan. Flexibility of the chitosan films increased with the lactic acid ratio for the both L- and DL-lactic acids. The L-lactic acid showed higher plasticization effect than the DL-lactic acid. Film transparency did not change, whereas wetability of the chitosan films increased as the lactic acid ratio increased.
  Y. Baimark and T. Phromsopha
  Methoxy poly (ethylene glycol)-b-poly (D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) films containing a poorly water-soluble drug were prepared by evaporation method of MPEG-b-PDLLG and drug solution in dichloromethane. Ibuprofen was used as a poorly water-insoluble model drug. Influences of MPEG block length and DLL/G ratio on drug-loaded film character and drug release behavior were investigated. Inhibition of entrapped ibuprofen crystallization in the MPEG-b-PDLLG films was observed from thermal analysis. The drug release rates increased as the MPEG block length increased. Incorporation of G units in the PDLL block also induced the faster drug release rate. The drug had released from the films through diffusion mechanism.
  T. Phromsopha and Y. Baimark
  In the present study biodegradable microparticles of chitosan were prepared by the simple water-in-oil emulsion solvent diffusion method for use as drug delivery systems. Aqueous chitosan solution and ethyl acetate were used as water and oil phases, respectively. Gentamicin sulphate was used as a hydrophilic model drug. Effects of drug content and sodium tripolyphosphate cross-linker on chitosan microparticles and drug release behaviors were investigated. The both drug-free and drug-loaded chitosan microparticles were deflated microparticles and porous structures with 200-400 μm in size. The cross-linking did not affect on microparticle shape and size. The drug release rates decreased as the drug content decreased and the amount of cross-linker increased.
  M. Srisa-Ard , Y. Baimark and Y. Srisuwan
  In this study, influence of intermolecular interactions between Silk Fibroin (SF) and Poly (ε-Caprolactone) (PCL) in homogeneous blend form on SF conformation changes and thermal properties of the blends was investigated and discussed. The SF/PCL blends were prepared by solution blending and precipitating method, respectively. Dimethylsulfoxide and isopropanol were used as a solvent and a non-solvent, respectively. The blends were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermo Gravimetry (TG) and Scanning Electron Microscopy (SEM). Conformation transition of SF component from β-sheet to random coil forms can be induced by blending with PCL. Melting temperature and heat of melting of the PCL decreased as increasing the SF ratio. Thermal stability of the SF can be enhanced by blending with PCL. FTIR, DSC and TG results suggested that intermolecular hydrogen bonds were formed between SF and PCL molecules in the blends. Homogeneous morphology of blends was illustrated by SEM micrographs.
  W. Simchua , N.A. Narkkong and Y. Baimark
  The application of Silk Fibroin (SF) nanospheres for controlled-release drug delivery was investigated. Drug-loaded SF nanospheres were rapidly prepared by nanoprecipitation method from SF and drug aqueous solution by using acetone as a non-solvent. Gentamicin sulfate was used as a model water-soluble drug. The drug-loaded nanospheres with 160-180 nm in size were spherical in shape and had a smooth surface. The SF nanosphere matrices were changed from random coil to β-sheet conformation by acetone treatment and drug entrapment. FTIR spectroscopy and thermogravimetric analyses indicated intermolecular interactions between SF and drug molecules. The cumulative in vitro drug release profiles from SF nanospheres showed initial rapid burst release followed with sustained-release behaviors. The drug release rate increased with the decreasing drug ratio. All these findings suggest that the SF nanospheres are potentially useful in drug delivery systems, especially hydrophilic drugs.
  T. Phromsopha and Y. Baimark
  Biodegradable films of methoxy poly (ethylene glycol)-b-poly (D, L-lactide) diblock copolymers (MPEG-b-PDLL) containing drug were prepared by solution casting of MPEG-b-PDLL and drug in dichloromethane. Ibuprofen was used as a poorly-water soluble model drug. Influences of MPEG-b-PDLL/drug ratio and film thickness on ibuprofen-loaded film characteristics and drug release behaviors were investigated. The hydrogen bonding between MPEG-b-PDLL and drug were detected from FTIR analysis. From FTIR and differential scanning calorimetric results indicated that the ibuprofen was well distributed throughout the MPEG-b-PDLL film matrices. The drug release rates increased as the drug ratio increased and the film thickness decreased. The drug release from the films occurred by drug diffusion mechanism.
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