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Articles by Y. Ouedraogo
Total Records ( 2 ) for Y. Ouedraogo
  R.G. Belemtougri , A. Traore , Y. Ouedraogo , S.D. Sanou and L. Sawadogo
  The aim of the present study was to investigate the toxicological effects of Sclerocarya birrea and Psidium guajava leaf extracts on mice and the antispasmodic effect on rat duodenum. The two plants extracts showed toxicological effects on mice in dose dependent manner. The antispasmodic effect was conducted as follow: In the first part of experiments, cumulative dose-response curve for Ach was obtained and then dose-response curves are repeated after addition of atropine and different doses of the extracts. In the second part, extracts were applied to the tissue after contraction with Ach. The extracts have exhibited an inhibitory effect on the dose-response curves induced by Ach on rat duodenum and significantly reduced the maximal response of Ach in a concentration-dependent manner. These results can partly justify the use of these plants in traditional medicine.
  R.G. Belemtougri , S.A. Dzamitika , Y. Ouedraogo and L. Sawadogo
  The present study was done to evaluate the hypotensive properties and the mechanisms action of the leaf aqueous extract in anaesthetized normotensive rats through a direct blood pressure measurement. The results showed that the extract caused a dose dependent fall in mean arterial pressure. Bilateral vagotomy did not abolished the hypotension induced by S. birrea. Pretreatment of rats with atropine, piperoxan and practolol did not abolished hypotension and suggests that muscarinic, α2 and β2 receptors are not involved in the induction of hypotension. These results suggest that the hypotensive effect of the extract is likely to be mediated through other factors like nitric oxide release or intracellular calcium decrease.
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