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Articles by Xiaodong Sun
Total Records ( 2 ) for Xiaodong Sun
  Zebin Yang , Mingtao Wang , Xiaodong Sun and Huangqiu Zhu
  In order to achieve the online detection problem of rotor speed for Bearingless Induction Motor (BIM), a speed identification scheme based on the Least Square Support Vector Machine (LSSVM) inverse is presented in this study. According to the inherent relationship among the variables of BIM, the speed subsystem is first built and proved to be invertible. Secondly, the inverse model was constructed using LSSVM which has good function approximation characteristics. And then the obtained inverse model is combined with this subsystem, which well realized the real-time rotation speed identification. Finally, a vector control simulation platform of BIM is established to evaluate the proposed method. The simulation results demonstrates the proposed LSSVM inverse method can accurately identify the speed parameter in a full speed operation region with good dynamic and static performance.
  Min Liu , Ritu Aneja , Xiaodong Sun , Songbo Xie , Hongxia Wang , Xiaojing Wu , Jin-Tang Dong , Minggang Li , Harish C. Joshi and Jun Zhou
  Eg5 is a motor protein of the kinesin family that is critical for spindle assembly during mitosis and has recently been implicated in tumorigenesis. It is largely unknown how Eg5 expression is regulated in cells. In this study, we present the first evidence that the cellular Eg5 level is down-regulated by Parkin, an E3 ubiquitin ligase well known for its role in the development of Parkinson disease. Our data show that Parkin does not trigger Eg5 protein degradation through the ubiquitin-proteasome pathway. Instead, Parkin represses Eg5 gene transcription by blocking c-Jun binding to the activator protein 1 site present in the Eg5 promoter. Our data further show that Parkin inactivates c-Jun NH2-terminal kinase (JNK), resulting in decreased phosphorylation of c-Jun. The inactivation of JNK is further mediated by multiple monoubiquitination of Hsp70. Importantly, both the ubiquitination of Hsp70 and the subsequent inactivation of the JNK-c-Jun pathway are crucial for Parkin to down-regulate Eg5 expression. These results thus uncover a novel function for Parkin in modulating the expression of Eg5 through the Hsp70-JNK-c-Jun signaling pathway.
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