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| Articles
by
Wafaa Ibrahim |
Total Records (
3 ) for
Wafaa Ibrahim |
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Ehab M.M. Ali
,
Wafaa Ibrahim
,
Rana M. Ashraf
and
Ehab Tousson
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Background: Thyroid hormone has profound effects on the cardiovascular
system and a regulatory effect on the rate of heme oxidation in the liver. Inducible
isoform of heme oxygenase (HO-1) protects the heart and vasculature
in pathological conditions. The present study aimed to identify the role of
heme oxygenase in cardiac changes in thyroidectomized rats. Materials and
Methods: Sixty male Wistar rats were equally divided into seven groups;
the first and second groups were the control and sham operated groups, respectively
while the 3rd and 4th groups were subjected to sham operation then treated with
hemin (G3) and KTZ (G4). The 5th group (G5)
was thyroidectomized group. The 6th and 7th groups were subjected to thyroidectomy
then treated with hemin (G5) and KTZ (G6), respectively.
Results: Hypothyroidism is documented by significant decrease in T3
accompanied with significant increase in serum TSH levels in thyroidectomized
rats. The results obtained revealed that oxidative stress due to hypothyroidism
has a detriment effect on cardiac tissue by depending on the result of cardiac
Protein Carbonyl Content (PCC) as a marker of tissue damage and a negative significant
correlation between cardiac PCC and serum Ferric Reducing Antioxidant Power
(FRAP) as marker of Total Antioxidant Capacity (TAC). The Inducible Nitric Oxide
Synthase (iNOS) activity in cardiac tissue showed significant decrease in thyroidectomized
rats and its value was increased significantly upon treatment with hemin or
ketoconazole (KTZ) as compared with sham operated rats. Treatment of thyroidectomized
rats with hemin improves the intensity of iNOS immunoreactive cells demonstrating
the recovery of some injury. Conclusion: There is a positive significant
correlation between hepatic HO and iNOS in cardiac tissue. The paradoxical effect
of both inducer and inhibitor of HO-1 on iNOS needs further studies.
Also, to address this inquiry we need further investigation on time and dose-dependent
effect of both inducer and inhibitor on cardiac tissue. |
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Afrah Salama
,
Wafaa Ibrahim
,
Tarek El-Nimr
,
Mahmoud A. Abd El-Rahman
and
Ehab Tousson
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Background: Diabetes is a metabolic disorder characterized by resistance
to the action of insulin, insufficient insulin secretion or both. The major
clinical manifestation of the diabetic state is hyperglycemia. However, insulin
deficiency and/or insulin resistance also are associated with disturbances in
lipid and protein metabolism. Myrrh (from the stem of the Commiphora molmol
tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis.
The effect of myrrh on diabetes treatment is still unknown, therefore this study
aimed to showing the effect of myrrh extract on diabetic rats. Materials
and Methods: A total of 100 Albino rats were equally divided to 5 groups
[control (G1), diabetic (G2), mirazid (G3),
co-treated diabetic rats with amaryl (G4) and co-treated diabetic
rats with mirazid (G5)]. Induction of Type II DM was carried out
by intraperitoneal injection of 65 mg kg-1 b.wt. of streptozotocin.
Many biochemical and physiological parameters were determined as changes in
body weight gain percent, oral glucose tolerance test, insulin, insulin sensitivity
percent, Liver glycogen content, fructosamine, liver and kidney functions. Also,
total protein and total antioxidant capacity in serum, liver and in kidney homogenate
in different groups under study were detected. Results: Myrrh extracts
have hypoglycemic activity through decreasing blood glucose level, enhancing
insulin secretion, increasing liver glycogen content and decreasing serum fructosamine.
Myrrh extracts have antioxidant activity through increasing total antioxidant
activity of serum and tissues, increasing total protein in tissues and enhancing
liver enzyme AST and kidney function. Conclusion: This study concluded
that Myrrh extracts have hypoglycemic activity and antioxidant activity through
decreasing total antioxidant activity. |
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