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Articles by V.M. Mounnissamy
Total Records ( 3 ) for V.M. Mounnissamy
  V.M. Mounnissamy , S. Kavimani , V. Balu and S. Darlin Quine
  The ethanol, water and chloroform extracts of the aerial parts of Cansjera rheedii J. Gmelin (Opiliaceae) were investigated for activity against Indian earthworms Pheretima posthuma. Various concentrations (5-40 mg mL-1) of each extract were tested, which involved determination of time of paralysis and time of death of the worms. All three extracts exhibited considerable anthelminthic activity. All the extracts (i.e., aqueous, chloroform and ethanol) at the tested dose (5-40 mg mL-1) level produced significant activity (p < 0.001) when compared with piperazine citrate (15 mg mL-1) and albendazole (20 mg mL-1) which were included as standard reference and normal saline as control. The present study indicates the potential usefulness of Cansjera rheedii aerial parts as anthelminthic activity.
  V.M. Mounnissamy , S. Kavimani , V. Balu and S. Darlin Quine
  The antipyretic activity of ethanol (95%) extracts of Cansjera rheedii J. Gmelin aerial parts of the plant was evaluated against brewer`s yeast-induced pyrexia in rats to assess their antipyretic activity. Rectal temperatures were recorded before and after inducing pyrexia at interval of one hour to five hours. At the same time parallel experiments were run with a standard antipyretic paracetamol (100 mg kg-1) and control (Normal Saline 5 mL kg-1). Ethanol extract of Cansjera rheedii J. Gmelin at dose of 250 mg and 500 mg kg-1 body weight showed the antipyretic activity significantly (p<0.001) compared to that of control.
  V.M. Mounnissamy , S. Kavimani , V. Balu and S. Darlin Quine
  The hepatoprotective activity of ethanol (95%) extract of (250 mg kgG-1) Cansjera rheedii J. Gmelin whole plant was evaluated against paracetamol induced hepatotoxicity by evaluating biochemical parameters such as Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphatase (ALP), Total bilirubin, Total Protein and Gamma Glutamate Transpeptidase (GGTP). A 10% of liver homogenate was used for estimation of enzyme such as Superoxide Dismutase (SOD), Glutathione S-Transferase (GST), Lipid Peroxidase (LPO) and Glutathione Peroxidase (GPx) for antioxidant study. Treatment of rats with ethanol extract significantly (p< 0.001) altered serum marker enzymes and antioxidants level near to normal against paracetamol intoxicated rats. Silymarin (50 mg kgG-1, p.o.) used as control.
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