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Articles by V. Jain
Total Records ( 7 ) for V. Jain
  S. Mandhania , V. Jain and S.P. Malhotra
  The present investigations were undertaken with the objective to isolate PME producing microbial strain and to standardize conditions to have cost effective production of the enzyme. Based on the ability of pectinolysis, out of 20 microbial strains isolated, one fungal strain was selected and got identified from Institute of Microbial Technology (IMTECH), Chandigarh (India), as Aspergillus heteromorphus. The strain was added to its collection with identification number MTCC 9262. Various process variables viz., type and pH of the medium, temperature of growth, time of incubation, inoculum concentration and type and concentration of carbon and nitrogen sources were optimized as per the conventional method of one variable at a time approach which involves varying a single independent variable and maintaining others at a constant level. Modified pectin medium-A, in which both Fe++ and Cu++ were omitted, gave the maximum growth of A. heteromorphus. Maximum PME production was obtained when an inoculum size of 4x106 spores mL-1 was incubated in modified pectin medium-A for 144 h at pH 4.5 and at a temperature of 30°C under static conditions in submerged fermentation. Out of the various nitrogen and carbon sources tested, dibasic ammonium phosphate and pectin were found to be the best N and C source, respectively. After standaradizing various process variables, a three fold increase in PME production by A. heteromorphus was achieved. Orange peel, a waste byproduct of fruit industry could effectively replace pectin as C-source thus, making the process cost effective. The PME produced by A. heteromorphus had the pH optimum in acidic range-a characteristic which could be exploited for its use in fruit processing industry.
  A. Vyas , S.S. Shukla , R. Pandey , V. Jain , V. Joshi and B. Gidwani
  Use of herbs to remedy many ailments is known since ages. Indeed, the use of herbs is not only natural way to remedy diseases but also without harmful side effects. Chervil (Anthriscus cerefolium) is a delicate annual herb, full of nutritional value. It is a common plant genus of the family Apiaceae. It comprises 12 species, some of which are considered as noxious weeds. The genus grows in meadows and verges on slightly wet porous soils. This plant finds wide use in treatment of various diseases. Also, it is considered safe to use this herb by the people throughout the world. It is also called ‘gourmet's parsley’. The active constituents of chervil are volatile oil, flavonoids and coumarins, other constituents present are methyl chavicol (estragole) and hendecane (undecane). This herb is used in kitchen for due to its nutritional aspect. The entire herb is advantageous, miraculous and nutritious in nature.
  V. Prasad , V. Jain and P.R. Mishra
  The present study was aimed to measure absorption and disposition of cyclosporine in endotoxin pretreated rats. Cyclosporine (Sandimmune, 10 mg kg-1) was orally administered with and without a concomitant dose of endotoxin (5 mg kg-1) i.p. to rats. Cyclosporine concentrations in blood samples were determined by HPLC UV detector. The pharmacokinetic parameters were calculated by noncompartmental analysis using WINNONLIN. The pretreatment of endotoxin in rats significantly increased cyclosporine AUC0-t (area under the concentration-time curve from time zero to the last point) by 33% in rats, indicating that the rats pretreating with endotoxin significantly increased cyclosporine oral bioavailability. In vitro absorption study was done to assess the effect of endotoxin on cyclosporine absorption. However, the significant increase in permeation drug into serosal side was noticed in rats, when pretreated with endotoxin, thus the inverted sac study also supported the finding of endotoxin inhibited the function of intestinal P-gp thus making cyclosporine more absorbed into lumen. The increased absorption of cyclosporine in both in vitro and in vivo may be due to inhibitory activity of endotoxin on intestinal P-gp and Cytochrome P4503A. This is significant in cases when cyclosporine was administered as immunosuppressant agent in patients suffering from septimea. A paired Student`s t-test was conducted for statistical comparison in all experiments.
  V. Prasad , V. Jain and A.K. Dorle
  V. Jain , V. Prasad and R.S. Pandey
  Desmodium gangeticum (DG) aqueous extract was investigated for its wound healing potential on different experimental models of wounds in rats. The aqueous extract of aerial part of DG, in powdered form was incorporated in ointment (10% w/w dried powder in simple ointment base) and was evaluated for wound-healing potential in an excision, incision and dead space wound model in rats. The DG ointment showed significant responses in all three-wound types tested when compared with the control group. The effect produced by the DG ointment, in terms of wound contracting ability, wound closure time, tensile strength of the wound, regeneration of tissues at wound site were comparable to those of a standard drug povidone iodine ointment.
  V. Jain , S.K. Verma , S.K. Sharma and S.S. Katewa
  Bombax ceiba Linn. (Red Silk Cotton Tree) commonly known as Semal tree; is a multipurpose tree species of tropical forests; providing food, fodder, fibre, fuel and medicine besides many ecological benefits. It is a dominant plant species of tropical dry deciduous forests of Southern Rajasthan, India. The present work is an attempt to justify the role of B. ceiba as an umbrella or life support tree for many animal species in forest areas of Southern Rajasthan. During the study period, total 43 animal species were observed who visited B. ceiba either for food, shelter or roosting purposes. Out of these, 29 species were from Avian fauna, 11 species belonged to Mammalia, two species belonged to Arthropoda and one from Reptilia. The present study confirms use of B. ceiba for balancing forest ecosystems and further recommends that this drought tolerant, easily propagable plant species should be planted in dotted fashion in forests specially in protected areas and also in home gardens as a keystone resource for many animal species.
  V. Jain , S.K. Verma , S.S. Katewa , S. Anandjiwala and B. Singh
  Silk cotton tree (Bombax ceiba Linn.) is a well known ethnomedicinal plant. Root of this plant was investigated for its antioxidant potential for the first time. Assessment of antioxidant activity was done using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay and Reducing power assay. Preliminary phytochemical screening of the roots showed presence of phenolics, tannins, flavonoids, steroids, saponins and cardiac glycosides. Methanolic extract of the roots showed high amount of phenolics (30.95% w/w) and tannins (15.45% w/w) and a very good DPPH radical scavenging activity (EC50 of 15.07 μg) in a dose dependent manner. The extract showed dose-dependent reduction ability (Fe3+ to Fe2+ transformation) with a maximum absorbance of 1.11 at a concentration of 500 μg of the extract. Acute study in healthy human volunteers showed a significant (p<0.05) rise in total antioxidant status at the end of 4 h after administration of 3 g root powder. This strong in vitro and in vivo antioxidant potential of B. ceiba dry root powder validates its uses in diabetes mellitus and heart disease as described in the traditional medicine.
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