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Articles by U.K. Sandabe
Total Records ( 2 ) for U.K. Sandabe
  S.H. Garba , J. Prasad and U.K. Sandabe
  The aqueous root-bark extract of Ficus sycomorus (Linn) was screened for its chemical constituents, median lethal dose and its histomorphological effect on the liver and kidney of albino rats. A total of 114 adult albino rats of both sexes weighing between 150-320 g were used in this study. The animals were weighed and randomly divided into two batches for the acute toxicity and histomorphological studies. In the acute toxicity study the aqueous extract of the root-bark of Ficus sycomorus was administered intraperitoneally (ip) in a dose range of 0.2-12 g kg-1 and the rats were observed for the physical signs of toxicity for 24 h. For the histomorphological effect of the extract on the liver and kidney 320, 640 and 1,280 mg kg-1 were administered to the rats for 2, 4 and 6 weeks, respectively. At the end of each treatment period, the animals were weighed before been sacrificed and the liver and kidneys were extracted, weighed and processed for histological assessment. Phytochemical screening of the extract showed the presence of saponins, flavonoids, alkaloids, tannins and reducing sugar while the median lethal dose (LD50 ) was calculated as 3.20±0.60 g kg-1. A significant decrease (p<0. 001) in body weight was observed but weights of kidney and liver treated with the extract were not affected significantly. Microscopic examination of the liver tissues of rats treated with the extract showed degenerative changes ranging from cytoplasmic vacuolation of hepatocytes, necrosis, dilatation of the central vein and proliferation of bile ducts. There was no observable effect on the kidney. The results of the study suggest that the extract possess hepatotoxic potentials and should be used with caution but a further research to assess the pharmacokinetics of the extract on cell membrane stability, lipid peroxidation, parenchymal cell regeneration and ultra structural study will be useful and is recommended.
  S.H. Garba , J. Prasad and U.K. Sandabe
  The aqueous root-bark extract of Ficus sycomorus (Linn) was tested for its chemical constituents, acute toxicity and hepatoprotective effect against Carbon tetrachloride (CCl4) induced hepatotoxicity in rats. A total of 78 adult albino rats weighing between 150-320 g were used. The animals were each weighed at the start of the experiment and divided into two segments consisting of 42 rats for the acute toxicity and 36 rats for the hepatoprotective study segments, respectively. In the acute toxicity study the aqueous extract of the root-bark of Ficus sycomorus was administered intraperitoneally (ip) in a dose range of 0.2-12 g kg-1 and the rats were observed for the physical signs of toxicity for 24 h. The hepatoprotective segment involved dosing the negative control rats intraperitonealy with carbon tetrachloride (CCl4) 3 mL kg-1 that was dissolved in corn oil to induce liver damage while the treatments groups were pretreated with 640 mg kg-1 of the extract orally an hour before CCl4 (3 mL kg-1) was administered to observe if the extract has any hepatoprotective effect against CCl4 induced hepatotoxicity At the end of each treatment period, the animals were weighed and blood was obtained from animals administered CCl4 and pre-treated with 640 mg kg-1 of the extract for biochemical analysis with the liver extracted, weighed and processed for histological assessment. Phytochemical analysis of the extract revealed the presence of saponins, flavonoids, alkaloids, tannins and reducing sugar and LD50 was calculated as 3.200.6031 g kg-1. Pre-treatment of the rats with the extract was able to reduce though not significantly, changes in the biochemical parameters (decrease in albumin but increase in Aspartate Transaminase (AST), Alanine-Transaminase (ALT), Alkaline Phosphatase (ALP) and bilirubin) and preserved the liver parenchymal architecture against CCl4 induced degenerative changes, fibroplasia and cirrhosis. The results of this study showed that the plant extract had hepatoprotective effect on the parenchymal architecture of the liver against CCL4 induced hepatotoxicity in rats. But further studies to observe its hepatocurative potentials would be useful and is recommended.
 
 
 
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