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by
Thangaraj Parimelazhagan |
Total Records (
1 ) for
Thangaraj Parimelazhagan |
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Blassan P. George
,
Thangaraj Parimelazhagan
,
Rahul Chandran
and
Shanmugam Saravanan
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Background: The present investigation has been undertaken to study the in
vitro and in vivo antioxidant potential of Rubus ellipticus and
Rubus niveus. Materials and Methods: Leaf, stem and root of the
Rubus plants was extracted in Soxhlet using petroleum ether, chloroform,
acetone and methanol and all the extracts were subjected to in vitro
antioxidant assays. R. ellipticus Leaf Methanol (RELM) and R. niveus
Root Acetone (RNRA) extracts were administered to test the in vivo antioxidant
levels after 30 days of treatment. Results: RELM and RNRA extracts depicted
maximum activity in most of the radical scavenging assays such as DPPH (1,1-diphenyl-2-picryl
hydrazyl), ABTS (2,2- azinobis -6-thiosulfonic acid), FRAP (ferric reducing
antioxidant power assay), nitric oxide, super oxide, hydroxyl radical etc. Therefore,
RELM and RNRA were taken for in vivo antioxidant screening. The 250 and
100 mg kg-1 of RELM and RNRA showed significant activities for catalase,
superoxide dismutase, glutathione peroxidase, glutathione S-transferase, glutathione
reductase and reduced glutathione. RNRA extracts showed superior antioxidant
activity compared to RELM. Conclusion: This study could suggest the use
of R. ellipticus and R. niveus as a valuable natural antioxidant
and has immense scope as an effective source to fight against the free radical
generated diseases. This study should also encourage the scientific search for
more medicinal properties from these species so as to combat the ever increasing
demand of medicine for the mankind. |
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