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Articles by T. Kunle-Alabi
Total Records ( 2 ) for T. Kunle-Alabi
  Y. Raji , F.O. Awobajo , Olufadekemi , T. Kunle-Alabi , M.A. Gbadegesin and A.F. Bolarinwa
  This study was carried out to investigate the individual impact of ampicillin and cloxacillin on male reproduction using both in vivo and in vitro models. In the in vivo study, forty adult male albino rats divided into five groups were treated daily with 0.5 mL sterile water (control), 4 mg/100 g b.w/day of ampicillin and 6 mg/100 g b.w/day of cloxacillin. Each drug treated group had a corresponding recovery group. Vehicle and drugs were administered orally for two weeks at the end of which rats were sacrificed; the recovery rats were sacrificed two weeks later. Body and reproductive organ weights and histomorphometric analyses of the testes and epididymides were carried out. Sperm counts, motility, viability and morphology and serum testosterone levels were determined. In the in vitro study, semen from the West African Dwarf Buck (WADB) was extended in graded concentrations (2.5, 5.0, 7.5, 10.0, 15.0 and 20.0 mg mL 1) of ampicillin and cloxacillin individually for 24, 48, 72, 96 and 120 h. The in vivo results show that both drugs did not adversely affect body weigh but caused significant reduction (p<0.05) in the weight of the testes, epididymides, seminal vesicles and prostate glands. Similarly there was a significant decrease in sperm counts, motility, viability and morphologically normal spermatozoa. Seminiferous tubular diameter and epididymal ductular diameter were significantly reduced (p<0.05) in both ampicillin and cloxacillin treated rats when compared with the control. These changes were accompanied by significant decrease in serum testosterone levels. Discontinuation of treatment led to recovery of organ weighs, testosterone secretion and sperm functions. In the in vitro experiments, sperm motility was significantly reduced (p<0.05) in the two drugs. This reduction was both dose and duration dependent. The results suggest that ampicillin and cloxacillin could induce reversible infertility in male, which could be mediated by decrease in testosterone secretion.
  Y. Raji , A.O. Morakinyo , A.K. Oloyo , O.S. Akinsomisoye , Olufadekemi , T. Kunle-Alabi , P.R.C. Esegbue-Peters and F.O. Awobajo
  The impact of oral administration of 100 mg kg 1 b.w of chloroform extract of Carica papaya seed (CPE) on oestrous cycle, fertility and serum 17 -oestradiol levels, in female rats was investigated. Ten proestrous rats received 2.5% tween 80 in normal saline (vehicle for CPE) and served as the control in each part of the study. In the oestrous cycle study, ten proestrous rats were treated with CPE for 14 days. The phases and frequencies of the oestrous cycles of the rats were determined daily for another 14 days while CPE treatment continued. In the fertility study, ten proestrous rats were treated as in the oestrous cycle study for 14 days and were thereafter cohabited with fertile untreated male rats for another 14 days while CPE treatment lasted. CPE did not adversely affect body weight of the rats. However there was a significant decrease (p<0.05) in the weight of the ovary, but not in the uterus. There was a significant decrease (p<0.01) in serum 17 -oestradiol levels in CPE treated rats. The oestrous cycle became irregular, with prolonged diestrous phase from the 3rd week of CPE treatment. There were disorganization and degeneration in the ovary. The uterus showed signs of vacuolation and mild disorganization. The extract treated rats produced a significant decrease in litter number (p<0.01) but the fetal weight and morphology remain unchanged relative to the control. The results suggest that chloroform extract of Carica papaya seed has antifertility properties, possibly acting via inhibition of oestrogen secretion.
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