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Articles by Sushma Yadav
Total Records ( 3 ) for Sushma Yadav
  Jozef Borvak , Mukesh Sahu , Varun Joy , Jyotsana Singhal , Sushma Yadav , Larry Xavier Oakford , Sejong Bae , Poorna Chandra Rao Lelsani , Amit Nangrani , Sharad Swaroop Singhal , Yogesh Chandra Awasthi and Sanjay Awasthi
  Problem statement: Dendritic Cells (DCs) integrate responses of innate and adaptive immune system via transmitting pro-inflammatory and regulatory signals to naive cells within draining lymph nodes. DCs have high capacity for endocytosis, both Clathrin-Dependent (CDE) and Caveolin-Dependent (CvDE). Approach: We have recently shown that ATP-hydrolysis by the multifunctional transporter protein RLIP76 is the primary determinant of the rate of CDE. Activation of CDE is necessary for DCs to internalize and process exogenous antigens. Thus, in present studies we investigated the role of RLIP76 in antigen uptake, maturation and T cell priming capacity of monocyte-derived DCs. Results: Using flow cytometry, we demonstrate variable surface expression of RLIP76 on immature DCs generated from peripheral blood mononuclear cells from healthy individuals. Studies on the effect of anti-RLIP76 antibodies on endocytosis of DC-specific C-type Lectin Receptors (CLRs) (DC-SIGN and DEC-205) and on co-localization of these receptors with MHC-class II were conducted using confocal microscopy. RLIP76-specific antibodies suppressed the maturation of DCs and the expression of typical activation markers and co-stimulatory and adhesion molecules including CD83, HLA-DR, HLA-ABC, CD40, CD80 and CD38. They also inhibited the stimulating potency of DCs in allogeneic Mixed Leukocyte Reaction (allo-MLR). Conclusions: We conclude that RLIP76 is necessary for activation, membrane trafficking and functional maturation of DCs. Further exploration of the role of RLIP76 in DC biology is warranted and may provide promising means in DC-based immunotherapies.
  Sushma Yadav and Anita Singh
  The present study was carried out (1) to provide nutrition education to the overweight and obese females and (2) to evaluate impact of nutrition education on their food habit and practices of physical exercise. The data were collected with the help of "Questionnaire cum Interview Technique." The questionnaire having all relevant information was pretested and pre designed the data were collected at two phases: one at initial phase of the study before implementation of nutrition education and secondly at post phase of the nutrition education. The base line study was conducted on 300 overweight and obese females purposely selected from four areas of the city. Equal number of subjects (one hundred each) were considered from high, middle and low income groups. Due to various constraints the nutrition education was imparted to 150 subject only. The inferences were drawn with the help of suitable statistical tools. Majority of the females were vegetarian (95.33%) at the initial phase of the study, but there was no change in this habit after imparting the nutrition education (p>0.05NS). So for as consumptions of food items and practices of physical exercise were concerned, there were significant changes (p<0.05). Practicing of good food habits were developed and consumption of sweet dishes, fatty fried items and cold drinks were discouraged.
  Sharad S. Singhal , Sushma Yadav , Kenneth Drake , Jyotsana Singhal and Sanjay Awasthi
  Hsf-1 (heat shock factor-1) is a transcription factor that is known to regulate cellular heat shock response through its binding with the multispecific transporter protein, Ralbp1. Results of present studies demonstrate that Hsf-1 causes specific and saturable inhibition of the transport activity of Ralbp1 and that the combination of Hsf-1 and POB1 causes nearly complete inhibition through specific bindings with Ralbp1. Augmentation of cellular levels of Hsf-1 and POB1 caused dramatic apoptosis in non-small cell lung cancer cell line H358 through Ralbp1 inhibition. These findings indicate a novel model for mutual regulation of Hsf-1 and Ralbp1 through Ralbp1-mediated sequestration of Hsf-1 in the cellular cytoskeleton and Hsf-1-mediated inhibition of the transport activity of membrane-bound Ralbp1.
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