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Articles by Sri Mulyani Sabang
Total Records ( 1 ) for Sri Mulyani Sabang
  Nurdin Rahman , Sri Mulyani Sabang , Nikmah Utami Dewi and Bohari
  Background and Objective: Preclinical testing of the use of avocado leaf extract for decreasing blood glucose level is still limited. This study aimed to analyze the effect of avocado leaf extract on fasting blood glucose level in male white rats. Materials and Methods: This study was a pre-experiment with six groups of pretest posttest with control group. The samples were male white rats (Rattus norvegicus) of Wistar strain, ±3 months old, with the treatment groups: Group 1: Feed+Streptozotocin (STZ)+10% sucrose+avocado leaf extract dose of 100 mg kg1 b.wt., Group 2: Feed+STZ+10% sucrose+avocado leaf extract dose 150 mg kg1 b.wt., Group 3: Feed+STZ+10% sucrose+avocado leaf extract dose 200 mg kg1 b.wt., Group 4: Feed+STZ+10% sucrose, Group 5: Feed+STZ+10% sucrose+glibenclamide and Group 6: Feed. Data analysis used ANOVA and paired t-test with p<0.05. Results: The early fasting blood glucose level of the white rats was 58-97 mg dL1 (p = 0.897). Giving STZ increases the fasting blood glucose level to 83-128 mg dL1 (p = 0.136). Meanwhile, giving avocado leaf extract on day 14 decreased 68-77 mg dL1 (p = 0.000). Group 2 experienced a significant decrease on day 7, which was 28.22 mg dL1 (p = 0.028) and day 14, which was 31.33 mg dL1 (p = 0.015). Conclusion: Avocado leaf extract with a dose of 150 mg kg1 b.wt. is effective in reducing the high fasting blood glucose level in white rats.
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