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Articles by Slamet Ibrahim
Total Records ( 5 ) for Slamet Ibrahim
  Jutti Levita , As`ari Nawawi , Abdul Mutalib and Slamet Ibrahim
  This study focuses on the anti-inflammatory activity of andrographolide, a diterpenoid compound from Andrographis paniculata, that have been observed in animals and in vitro in different cells of human and animals. Studies included activities of andrographolide and the features of the target, especially limited to transcription factors NF-kappaB. The active site of NF-kappaB, called DNA binding region is found to have mainly positive potential. In order to have an electrostatic complementarity specific inhibitor should have negative potential. Andrographolide has three hydrogen bond donors (H atoms in hydroxyl groups attached to C-3, C-19 and C-14), five hydrogen bond acceptors (O atoms in hydroxyl groups attached to C-3, C-19 and C-14, carbonyl and lactone) and log P-value 2.9. It fulfills Lipinski’s rules of five criteria of drug properties. This compound has different mechanisms of anti-inflammatory activity. It can inhibit the activation of NF-kappaB, suppresses inducible nitric oxide synthase (iNOS) expression. It also prevents oxygen radical production by human neutrophils and inhibits COX-2 expression in human fibroblast cells. This compound also exerts anticancer and antitumour activities, hepatoprotective against various inducers, immunomodulator, antioxidant, antidiabetic, antimicrobe and antivirus activities. Synthetic analogues of the compound which have been created and analyzed also showed similar activities.
  Leni Herliani Afrianti Priyatno , Elin Yulinah Sukandar , Slamet Ibrahim and I. Ketut Adnyana
  The compound of 3β-hydroxy-sitosterol (1) and 2-metylester-1-H-pyrrole-4-carboxilyc acid were isolated from ethyl acetate extract of snake fruit (Salacca edulis Reinw) cv. Bongkok, (2). Inhibition of xanthine oxidase by the two compounds were evaluated against enzyme of xanthine oxidase. Compound 1 could be regarded as inactive, while compound 2 was found to be active with IC50 value of 48.86 μg mL-1.
  Jutti Levita , As `ari Nawawi , Abdul Mutholib and Slamet Ibrahim
  The aim of this study was to identify and analyze the interaction of andrographolide with COX-2, followed by in vitro study of the effect of this compound on COX-2 expression in human fibroblast cells. The molecular modeling study was performed by docking andrographolide to COX-2 enzyme at the site where SC-558, a selective inhibitor of this enzyme, was co-crystallized and compared its interaction to the enzyme with SC-558’s. The inhibition of COX-2 expression was determined by measuring PGE2 production in human fibroblast cells stimulated with LPS with and without andrographolide preincubations. Andrographolide interacted with Arg513 and His90 in the cyclooxygenase site of COX-2 and inhibited PGE2 production in human fibroblast cells (IC50 = 4 μM). These data confirm that andrographolide’s anti-inflammatory activity occurs via inhibition of COX-2 expression.
  Aliya Nur Hasanah , Rahmana Emran Kartasasmita and Slamet Ibrahim
  Glibenclamide is a second-generation sulfonylurea drugs for treatment of diabetes mellitus. Up to now, a glibenclamide imprinted polymer is not reported for molecular recognition in biological samples. This research is conducted to have Molecular Imprinted Solid Phase Extraction (MISPE) for separation of glibenclamide from serum samples. The results showed that the itaconic acid is the functional monomer that provides the best interaction with the template (glibenclamide) from the computational study using Gaussian 09 software. The MISPE made from itaconic acid monomer at a ratio of 1:6:70 gives the best binding to glibenclamide in methanol pH 4. Serum sample which was spiked with glibenclamide gives recovery more than 80% after pretreatment with MISPE 2 in all concentration ranges. Selectivity test showed that MISPE 2 can be used for selective extraction of glibenclamide from serum samples spiked with other sulfonylurea drugs. This developed MISPE could be further used as extraction method in antidiabetic drugs analysis from biological samples.
  Asmiyenti D. Djalil , R.E. Kartasasmita , Slamet Ibrahim and Daryono Hadi Tjahjono
  Tetrapyrrolic macrocycles bearing carboxylic acid groups have received considerable interest as photosensitizing agent for Photodynamic Therapy (PDT). It is necessary to consider the toxic potency of those compounds. The present study was designed to predict the toxicities of tetrapyrrolic compounds using Ecological Structure Activity Relationships (ECOSAR) and Toxtree, for further use in design and synthesis of photosensitizers. The ECOSAR prediction showed that tetrapyrrolic macrocycles with more carboxylic acid groups or hydroxyl groups showed lower toxic potency than those with fewer carboxylic acid groups or hydroxyl groups. Toxicities estimation using Toxtree to human and based on the Cramer rules, Verhaar, Structural Alerts for Reactivity in Toxtree (START) biodegradability, eye irritation/corrosion and skin irritation/corrosion, all of the compounds fell into class 3, 5, 2, 1 and 1, respectively. Application of the Benigni-Bossa method showed that all studied compounds had structural alerts for genotoxic carcinogenicity. Cytochrome P-450 mediated drug metabolism was positive for all site of metabolism except for PPIX-1OH and PPIX-2OH. Most of the studied tetrapyrrolic compounds fell into unreactive group of compounds by Michael addition classification, except for purpurin 7 and rhodin g7. Skin sensitization evaluation of all compounds were alert to Michael acceptor, except for BPhe a-OH. Moreover, Kroes Threshold of Toxicological Concern (TTC) decision tree had negligible risk for all compounds.
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