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Articles by Shun Lu
Total Records ( 2 ) for Shun Lu
  Xiao Yao , Hua Jiang , Cuizhen Zhang , Huamao Wang , Lin Yang , Yongfeng Yu , Junming Yu , Bizhi Shi , Zhijun Shen , Huiping Gao , Zhiwei Chen , Shujun Tian , Shun Lu , Zonghai Li and Jianren Gu
  Objective: We investigated whether or not there are autoantibodies for DKK1 (Dickkopf-1) in patients with non-small cell lung cancer (NSCLC) and whether this autoantibody can be used for cancer detection.
The levels of DKK1 autoantibodies were determined in 93 NSCLC patients and 87 healthy controls.
Results: We found that, in the sera, the presence of autoantibody against DKK1 was highly correlated with NSCLC. High anti-DKK1 autoantibody titres were found in the sera of NSCLC patients, whereas low or negative titres were found in the control group. The ROC curve results showed that autoantibody immunoassay exhibited 62% sensitivity and 84% specificity. The sensitivity for the detection of NSCLC in stage I also reach 64.3%. Furthermore, a combined ELISA assays for both DKK1 and autoantibody DKK1 increased sensitivity and classified 81.7% (76/93) of the NSCLC patients as positive, whereas only 13.8 % (12/87) of healthy volunteers were falsely diagnosed as positive.
Conclusions: Our results suggest that the detection of circulating DKK1 autoantibody could potentially serve as a useful non-invasive marker for determining lung cancer status.
  Xinting Zheng , Kemei Peng , Juan Tang , Wei Wang , Ke Xiao , Daiyun Zhu , Shun Lu , Keli Yang , Jing Wang , Pengpeng Sun and Min Chen
  The aim of this study was to determine the effects of supplemental drinking boron on morphology of ostrich chicks’ cerebrum. Twenty four hatched ostrich chicks were divided into six group (I-VI) and supplemented by the water with 0, 40, 80, 160, 320 and 640 mg L-1 boron, respectively for 45 days. Cerebrums were obtained and weighed after dissection then measured the transverse diameter, longitudinal diameter and height of cerebral hemisphere immediately. Paraffin embedded sections of cerebral tissues (4 μm thick) were stained with HE, Nissl’s and argentaffin and then micro photographed. It showed significant increase (p<0.05 or p<0.01) in each anatomy index of group IV in comparison with the other groups while group VI showed significant decrease. Histology study showed that neurons of the cerebrum of group I and II were alike, nerve fibers passed horizontally within the cortex. Neurons of group III were varied in size and shape and with abundance of nerve fibers passed horizontally within the cortex tighter. Whereas neurons of group IV had more types than the rest of groups and were well arranged from the edge to inside by size, the nerve fibers were rich and interweaved. In contrast, neurons of group V and VI were monomorphic with less neurite and nerve fibers were tenuous and sparse. Findings showed that 80-160 mg L-1 supplemental drinking boron promotes cerebrum development, neurons differentiation, neurite formation and nerve fibers elongation of the cerebrum of 0-45 days old ostrich chicks.
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