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Articles by Shakeela Naz
Total Records ( 3 ) for Shakeela Naz
  Shakeela Naz , Tahira Iqbal , Munir Ahmad Sheikh , Muhammad Shahid and Abdul Ghaffar
  Brevibacterium flavum maintained at 7.0 pH level and at 37 °C temperature, gives maximum production of lysine. When the organism was given UV shocks for 30 minutes, gave the lysine in maximum quality. Water substrate ratio, addition of molasses, addition of corn steep liquor were optimized. At 40% water substrate ratio, addition of 4% corn steep liquor and 4% molasses bacteria was most efficient in the production of lysine. The biomass thus produced contained 32.8% crude protein, 20.87% true protein, 34% ash and 1.1% fat contents on the basis of dry matter. There was no increase or decrease in ether extract and crude fiber. The biomass produced was analyzed by three-enzyme method. Its digestibility was 85.69% in single cell protein biomass. Amino acid profile showed that lysine production was 21.48mg/g on the basis of protein.
  Aftab Ahmad , Munir Ahmad Sheikh , Muhammad Nawaz , Muhammad Shahid , Abdul Ghaffar and Shakeela Naz
  Biodisposition of drug was investigated in male volunteers following the oral dose of 250mg. Blood samples were collected after predetermined schedule and drug concentration was determined by microbiological assay. The two compartment model kinetics analysis of plasma clarithromycin concentration versus time data revealed that the average ± SD values of t1/2ß, clearance and volume of distribution are 1.36±0.14h, 20.43±3.04 l/h and 39.91±1.461 l/kg respectively. The absorption rate constant, area under curve (AUC) and mean resident time with ± SD are 0.51±0.05h, 12.36±1.43 and 4.17±43 h respectively.
  Sheikh, M.A. , S. Khanum , A. Ahmad , T. Iqbal , Z. Hydair and Shakeela Naz
  Levofloxacin is a quinolone antimicrobial which acts through the inhibition of bacterial topoisomerases that has been developed mostly for clinical use in human medicine. Its protein binding was investigated in human beings under indigenous conditions. Drug concentration of 1, 2, 3, 4 and 5 g/ml were added to the plasma and binding of levofloxacin was determined by ultrafiltration and its concentration in ultrafiltrates was determined by microbiological assay. The binding of levofloxacin showed positive correlation between drug concentration and percentage bound drug and maximum binding was observed at 5 g/ml and 59% in human beings. The pH of plasma also affected the binding, being highest at 7.4 in human beings, and it was 53%. In vitro binding of levofloxacin was maximum at normal level of blood protein.
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