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Articles by Shafiqur Rahman
Total Records ( 2 ) for Shafiqur Rahman
  S.M. Raquibul Hasan , Mariam Jamila , Muntasir Mamun Majumder , Raushanara Akter , Md. Mokarram Hossain , Md. Ehsanul Hoque Mazumder , Md. Ashraful Alam , Rumana Jahangir , Md. Sohel Rana , Md. Arif and Shafiqur Rahman
  Problem statement: Mikania scandens (L.) Willd., a medicinal plant, is popularly used as herbal remedy for various ailments in Bangladesh. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of the plant. Approach: The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The hydromethanol extract was also investigated for its antioxidant action using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. Results: The extract, at the dose of 250 and 500 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg-1) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL-1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL-1. The IC50 values of the extract and ascorbic acid were 220.43 and 125.10 μg mL-1, respectively in NO scavenging assay. Conclusion: The findings of the study suggested that the extract from Mikania scandens has strong analgesic and antioxidant effects.
  Shafiqur Rahman , Mohd. Zakaria-Ismail , Pek Yee Tang and Sekaran Muniandy
  The genetic variability of wild populations of green arowana (Scleropages formosus) from Tasek Bera Lake and Endau River and a captive stock of Malaysian golden arowana as an out-group population was studied. The average number of alleles per locus was low, ranging from 2.33 in the Endau River population to 2.56 in the Tasek Bera Lake population. Departures from Hardy-Weinberg equilibrium were observed in these three populations depending on the locus. Among nine loci, seven significantly deviated from Hardy-Weinberg Equilibrium (p<0.05) in the Tasek Bera Lake population whereas five significantly departed from HWE (p<0.05) in the Endau River population. A deficit of heterozygosity was observed from the analysis of these nine loci. This genetic data indicate the wild population may be under stress due to inbreeding, over fishing and deterioration in the breeding environment. The estimates of FST and RST were statistically greater than zero for each comparison and this suggested the existence of three genetically distinct populations. However, the values of FST is low between Tasek Bera Lake and Endau River populations, reflecting historical patterns of connections between river systems in Peninsular Malaysia.
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