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Articles by Seyed Nasser Ostad
Total Records ( 2 ) for Seyed Nasser Ostad
  Seyed Nasser Ostad , Mohsen Amini , Zahra Haghipour , Leila Karimi and Latifeh Navidpour
  Recent studies have suggested cyclooxygenase-2 (COX-2) expression as a mechanism involved in carcinogenesis. It has also been suggested that changes in COX-2 expression level can be considered as a possible therapeutic target in tumors. Therefore, it was decided to synthesize a new series of 4, 5-diaryl thiadiazoles (compounds 1-5) as COX-2 inhibitors and evaluate their inhibitory activity on COX-2 expression. The COX-2 expression was induced by lipopolysaccharide (LPS) in bovine aortic endothelial (BAE-1) cells and the protein expression was evaluated by immunocytochemistry (ICC). The inhibitory activity of these compounds has been compared with celecoxib and rofecoxib as selective COX-2 inhibitors and indomethacin as a non-selective COX inhibitor. The cytotoxicity of these compounds was measured in different concentrations (10-3 -103 μg mL-1 ) by trypan blue dye exclusion method. The results showed that the cell viability following exposure to 10-2 μg mL-1 of each one of compounds 1-4 was about 90%. Among all tested compounds, compound 4 at 10-2 μg mL-1 showed significant inhibition on COX-2 expression determined by ICC. This effect of compound 4 was comparable to rofecoxib and celecoxib. It is concluded that, the new synthesized compounds and in particular, the compound 4 can be considered for further evaluation as new COX-2 inhibitors.
  Fereshteh Golfakhrabadi , Seyed Nasser Ostad , Mitra Hafizi , Mohammad Reza Shams Ardekani , Soodabeh Saeidnia , Tahmineh Akbarzadeh and Mahnaz Khanavi
  Ferulago carduchorum Boiss and Hausskn (Apiaceae) is an endemic plant in West of Iran and it are used in dairy and oil ghee as a natural preservative. The aerial parts of F. carduchorum were extracted by percolation method with MeOH/H2O (80/20) and the fractions were provided respectively with hexane, ethyl acetate, methanol, methanol/H2O (50/50). The fractions have been investigated their phytochemical screening and the cytotoxic activity against the colon carcinoma (HT29), the breast ducal carcinoma (T47D), the hepatocellular carcinoma (HepG2) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines by MTT (3-(4, 5-di methyl thiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. Phytochemical screening revealed the presence of phytosteroids, flavonoids, coumarins and saponins. The cytotoxicity of ethyl acetate and hexane fractions showed more efficacy than the other fractions on T47D and HepG2 cell lines (IC50<100 μg mL-1) could be attributed to their content of coumarins and phytosteroids. The hexane fraction was selected for phytochemical study and suberosin (a coumarin) isolated from hexane fraction as an active compound. The Selective Index (SI) value of ethyl acetate fraction was lower in HepG2, T47D and HT29 cell lines than hexane fraction that indicated the selective effect of ethyl acetate fraction on this cell lines.
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