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Articles by Seyed Mehdi Razavi
Total Records ( 5 ) for Seyed Mehdi Razavi
  Seyed Mehdi Razavi
  In the last decades, application of synthetic toxins for control of weeds, pests and plant disease caused serious environmental problems. Allelopathy is regarded as a natural strategy in plants protecting them against environmental enemies and competing plants. This process involve plant secondary metabolites that suppress the growth and development of surrounding biological systems and named as allelochemicals. Thus, allelopathy interactions between plants and other organisms may become an alternative to synthetic herbicides and other pesticides. Coumarins are known as a large group of plant secondary metabolites mainly originated from shikimic acid pathway. This compounds are widely distributed in the Apiaceae, Rutaceae, Asteraceae and Fabaceae families of plants. Up to now, there has been many reports on phytotoxic, fungitoxic, insecticide, antibacterial and nematocidal activity of different coumarins. This reports demonstrated that some coumarins like imperatorin and psoralen exhibited considerable allochemical potential. Therefore, this compounds could be utilized to generate a new generation of bioherbicides and other pesticide chemicals that are more ecologically friendly.
  Seyed Mehdi Razavi and Samad Nejad-Ebrahimi
  Crambe orientalis L. (Brassicaceae), a perennial herb, is indigenous to Iran. The essential oils of flowering tops and leaves of the plant were evaluated by GC-MS. Our results showed that while 2-methyl-5-hexenitrile (19.5%) and benzyl cyanide (16.9%) were the major components of flowering tops oil, the oil of the leaves was dominated by octyl-acetate (54.3%) and butenyl-4-isothiocyanates (22.6%). The oils exhibited modest allelopatic effects on lettuce. The leaf oil showed high-cytotoxic effects against Mc-Coy cell lines, with an RC50 value of 16 μg mL-1.
  Seyed Mehdi Razavi , Saber Zahri , Hossein Nazemiyeh , Gholamreza Zarrini , Sariyeh Mohammadi and Mohammad-Amin Abolghassemi-Fakhri
  A known furanocoumarin, 8-geranyloxy psoralen, was isolated from n-hexane extract of Prangos uloptera roots by the TLC method. Its structure was determined by comparison of the spectral data with the literature. Cytotoxic effects of the isolated compound were determined by MTT and Tripan blue assays. The antioxidant and antimicrobial potential of the compound were evaluated by DPPH assay and agar dilution method, respectively. The MTT assay results showed that 8-geranyloxy psoralen reduced cell viability of Hela and Mc-Coy cell lines with IC50 values of 0.792 and 0.835 mM, respectively. Based on the Tripan blue asay, the compound has cytotoxic effects, with an IC50 value of 1.26 mM for Mc-Coy cell line. The compound exhibited weak antioxidant potential, with an RC50 value of 0.262 mg mL-1 and high antimicrobial effects against Staphylococcus epidermidis and Candida kefyr.
  Seyed Mehdi Razavi , Gholamreza Zarrini and Ghader Molavi
  Mentha longifolia (L.) Huds. is a perennial rhizomatous herb distributed from Southern Africa, Europe, the Mediterranean region and eastwards into Asia. Mentha species are also generally known under name of Puneh in Iran where they have been used for centuries as tonics, carminative, digestive, stomachic, antispasmodic and anti-inflammatory agent in folk medicine. In the present work, we study antimicrobial and cytotoxic activity of the plant extracts. The antibacterial and antifungal activity of the plant extracts were evaluated using disk diffusion method. We evaluated cytotoxicity of M. longifolia with MTT assay, as well as. Present finding revealed that the methanol extract of the plant leaves were active against all tested bacteria and fungi. The highest inhibitory effect was observed against Erwinia carotovora, a common plant pathogen bacteria, with MIC value of 128 μg mL-1 and inhibition zone of 41 mm. The extract also exhibited high antibacterial activity with MIC value rang of 192-512 μg mL-1 and inhibition zone of 34-40 mm against S. aureus, Enterococcus faecalis, Streptococcus agalactiae and Escherichia coli. The methanol extract of the plant displayed modest to strong antifungal activity against Candida kefyr, Candida albicans, Sclerotinia sclerotiorum and Aspergillus niger with MIC value range of 576-800 μg mL-1 and inhibition zone of 26-33 mm. Our finding showed that M. longifolia methanol extract has cytotoxic activity. The extract reduced the viability of McCoy cells with RC50 value of 1.92 mg mL-1. It was be concluded that M. longifolia extract cab be used as an antiseptic agent and may be also a good candidate to construction of a new plant biopesticide.
  Sara Baniebrahim and Seyed Mehdi Razavi
  Background: Echinophora orientalis is perennial, crowded and much branched herb distribute from Turkey to Iran and Caucasia. There is no report on essential oil composition of Echinophora orientalis in Iran. However, the chemical composition of the plant oil was determined in Turkey where the main compounds of oil were reported as: Myrcene (34.2%) and p-cymene (18.9%). This study was focused on the composition of the essential oil of Echinophora orientalis leaves. Materials and methods: The powdered air dried of Echinophora orientalis aerial parts were distillated for 3 h by a Clevenger type apparatus. The chemical composition of the hydrodistilled essential oil was analyzed by GC-MS. The oil components were identified by comparison of their RI with those reported in the literature and their mass spectrum was compared with Wiley Library. Results: Totally, 23 compounds were identified comprising 99.9% of the oil. β-myrcene (32.1%) was the main constituent of oil, followed by α-pinene (16.7%) and p-cymene (14.34%). The results showed monoterpenes dominated in leaf oils. Conclusion: The comparison of the result with literature showed the essential oil composition profile of Echinophora orientalis collected from Iran is similar to those of Eastern Turkey. Thus, it is assumed that two samples of Echinophora might be of same chemotype. It was previously shown that β-myrcene has different bioactivities. It was assumed that the oil of E. orientalis might be exhibited various pharmacological and biological properties.
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