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Articles by Seyed Adel Moallem
Total Records ( 4 ) for Seyed Adel Moallem
  Seyed Adel Moallem , Farzin Hadizadeh and Isa Yavar
  A group of N-aryl- 4-(methylsulfonyl)aminobenzenesulfonamides, possessing a (methylsulfonyl) amino pharmacophore at the para-position of the one phenyl ring, in conjunction with another substituted phenyl ring (4-F, 4-H, 4-Me, 4-OMe) were evaluated as selective cyclooxygenase-2 (COX-2) inhibitors. In vitro COX-2 isozyme inhibition structure–activity studies identified 6e with 4-OMe substituent as a potent COX-2 inhibitor (IC50 = 1.59 μM) with a high COX-2 selectivity index (SI = 51.7) comparable to the reference drug celecoxib (COX-2 IC50 = 9.59 μM; COX-2 SI = 25.62). The structure-activity data acquired indicate that the sulfonamido moiety constitutes a suitable scaffold to design new acyclic N-aryl- 4-(methysulfonyl)aminobenzenesulfonamides derivatives with selective COX-2 inhibitory activity.
  Seyed Adel Moallem and Leila Jahangiri
  Mesothelial progenitor cells have been reported to reside in either the monolayer of mesothelium, submesothelium or within the peritoneal cavity as free floating cells. As a putative plasticity has been reported for the mesothelial progenitor cells and considering the potential implications of the establishment of a novel resource of stem /progenitor cells in gene and cell therapeutics and tissue engineering, we conducted an in vivo tracking of transplanted mesothelial cells. In order to induce immunodeficiency, the recipient mice were treated with 32 mg kg-1 of daily Cyclosporine. On days 14, 30 and 60 post transplantation, brain, heart, skeletal muscle and lung tissues were screened by a modified FISH method directed to the Y chromosome of donor cells. Fluorescence harboring cells were analyzed by flow cytometry and fluorescent microscopy. The data confirmed by PCR, demonstrated the existence morphology alteration of the donor cells in various organs of the recipient mice, notably in the skeletal muscle and lung and less in the heart and brain. Immunostaining of recovered cells from the nervous recipient tissues suggests differentiation of mesothelial cells in the new microenvironment.
  Seyed Hadi Mousavi , Seyed Adel Moallem , Soghra Mehri , Shabnam Shahsavand , Horiyeh Nassirli and Bizhan Malaekeh-Nikouei
  Objective: Saffron Crocus sativus L. (Iridaceae) is known for anticancer properties. However, limited effort has been made to correlate these effects to the active ingredients of saffron. In the present study, cytotoxic effects of crocin, the major coloring compound in saffron, and its nanoliposomal form for better cellular delivery are investigated. Methods: HeLa and MCF-7 cells were cultured and exposed to crocin (1, 2, and 4 mM) and liposomal crocin (0.5 and 1 mM). The 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was performed to assess cytotoxicity. Apoptotic cells were determined using propidium iodide (PI) staining of DNA fragmentation by flow cytometry. Results: MTT assay revealed a remarkable and concentration-dependent cytotoxic effect of crocin on HeLa and MCF-7 cells in comparison with non-malignant cell line (L929). Crocin liposomal forms (IC50 values after 48 h: 0.61, 0.64, and 1.2 mM) showed enhanced cytotoxic effect compared with the crocin (IC50 after 48 h: 1.603 mM) in HeLa cells. Crocin and its liposomal form induced a sub-G1 peak in flow cytometry histogram of treated cells indicating apoptosis is involved in this toxicity. Liposomal encapsulation enhances apoptogenic effects of crocin on cancerous cells. Conclusion: It might be concluded that crocin and its liposomes could cause cell death in HeLa and MCF-7 cells, in which liposomal encapsulation improved cytotoxic effects. They could be also considered as a promising chemotherapeutic agent in cancer treatment in future.
  Leila Etemad , Reza Zafari , Naser Vahdati- Mashhadian , Seyed Adel Moallem , Zahra Oskouei Shirvan and Hossein Hosseinzadeh
  Verbascoside or acteoside is the most abundant phenylethanoid glycoside that possesses health beneficial pharmacological activities, including anti-nociceptive, anti-inflammatory and anti-cancer. Due to the wide range of pharmacological activities of verbascoside and insufficient data on the safety profile, the acute, subacute and cellular toxicity of verbascoside was determined. The acute and subacute toxicity of verbascoside was evaluated in mice after single intraperitoneal injection at the dose range of 0, 1, 2 and 5 g kg–1 b.wt. (acute model) and 21 days administration at the dose range of 0, 10, 30 and 60 mg kg–1 b.wt. (subacute model). In MTT assay, HepG2 and NIH cells were exposed to different concentrations of verbascoside. According to result, the LD50 value of verbascoside was found to be greater than 5 g kg–1. In subacute toxicity study, no statistically significant differences were observed in the values of hematological, biochemical and pathological parameters in comparison with control group. The cytotoxicity assay revealed that the viability in all groups were greater than the IC50 value. In conclusion, the results from the present study elucidate that verbascoside is well tolerated for both single and chronic administration and does not produce any toxic effects or deaths in animals.
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