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Articles by Saeed Ahmed
Total Records ( 3 ) for Saeed Ahmed
  Muhammad Khan Sarfraz , Nisar -ur-Rehman , Saeed Ahmed , Mohammad Ashraf and Sabeeh Mohsin
  The present study was conducted to develop sustained release matrix tablets of naproxen with the help of a hydrophobic polymer, Ethyl Cellulose (EC). Matrix tablets were prepared by incorporating various proportions of EC in the matrix system using wet granulation technique. The rate of drug release from the matrix tablets was found to be very slow and could not produce the desired release profiles in 12 h testing time. However, the tablets prepared by slightly modifying the wet granulation method exhibited comparatively linear and desirable release rate. No significant difference in the release profiles of naproxen matrix tablets was observed at different stirring speeds and storage conditions.
  Saeed Ahmed , Mohammad Ashraf , Abdul Jabbar , Khalid Hussain Janbaz , M. Shafiq Khan , Nisar-ur-Rahman and Munawar Hussain
  The present research demonstrates the biological activity of Dipterygium glaucum since extensive literature survey has shown no documented biological activity of this plant. Ethanol (80%) extract (A) of the plant was subfractioned by hexane (B), ethyl acetate (C) and butanol (D). These fractions (1 mg mL-1) of D. glaucum showed 45 to 100% phytotoxicity as determined by the inhibition of Lemna minor plant growth but showed no cytotoxicity by brine shrimp lethality assay. DPPH radical scavenging activity of fraction `A` was 87% whilst other fractions had antioxidant activity below 35%. When fraction `A` was tested for antispasmodic activity, spontaneous contractions were recorded at 0.1-3.0 mg mL-1 concentration in isolated rabbit jejunum preparations. It also inhibited K+ induced contractions to 60% at 1-3 mg mL-1 level, suggesting a calcium channel blockade activity. The n-hexane (B), ethyl acetate (C) and n-butanol (D) fractions exhibited no or little antibacterial, antifungal, antileishmanial and insecticidal activities as compared with their respective controls. This is the first report on the biological activity of D. glaucum.
  Muhammad Ali , Waqar Ali , Saeed Ahmed and Ikram Ullah
  Tallow samples were obtained form the local slaughterhouses and were evaluated for iodine value, saponification value, anisidine value, acid value, peroxide value, FFA, ash content and cholesterol content. The results were compared with that of Codex standard for the edible animal fats. The acid value of tallow was 1.009-1.99 mg KOH/g. The saponification value (195-197 mg KOH/g) indicate that the tallow contain high molecular weight fatty acids. The iodine values (48.66-49.15) suggest a low degree of unsaturation compared to palm oil. The FFA, AnV and POV were 0.507-1.00 (as oleic acid %by wt.), 6.33- 9.57 and 3-6.5 (meq / kg) respectively. The cholesterol and %ash content were in the range of 1.00-1.10 (mg/g) and 0.183-0.57, respectively. In minerals, the level of Na is 10.037-18.952 ppm, K (2.216-2.821 ppm), Ca (1.123-1.752 ppm), Cu (0.001 ppm), Fe (0.430-0.493 ppm), Pb (1.147-1.153 ppm), Mg (0.412-0.473 ppm), Cd (0.070-0.071 ppm), Zn (0.028-0.055 ppm) and Cr (0.896-0.982 ppm).
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