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Articles by Sabry Ali El-Naggar
Total Records ( 2 ) for Sabry Ali El-Naggar
  Sabry Ali El-Naggar , Karim Samy El-Said , Adel Abd Al Hameed Albagoury , Violet Sobhy Awad and Laila Hamada Attia
  Background and Objectives: Several studies have been investigated the natural components as an alternative cancer therapy. This study aimed to address the antitumor efficacy of Prunus armeniaca seed extract (PASE) and Prunus domestica seed extract (PDSE). Materials and Methods: Phytochemical analysis and gas chromatography-mass spectroscopy (GC-MS) profile, human breast (MCF-7), hepatic (HepG-2) cancer cell lines and Ehrlich ascetic carcinoma (EAC) were used to determine the anticancer efficacy. Results: Total phenolic, flavonoids, saponin and anthocyanin in PASE were 1291 μg mL1, 159 μg mL1, 16 mg g1 and 65 μg mL1, respectively. While, in PDSE were 729 μg mL1, 63 μg mL1, 7.6 mg g1 and 89 μg mL1, respectively. The GC-MS analysis showed that the highest peak area (%) in PASE was octasiloxane-hexadecamethyl (17.04%) and in PDSE was hexadecanoic acid, trimethylsilyl ester (31.92%). In vitro inhibition concentration (IC50) of PASE and PDSE against MCF-7 were 31.5 and 306, respectively. The IC50 of PASE and PDSE against HepG-2 were 22.8 and 430 μg mL1, respectively. The PASE had a potent anticancer activity higher than PDSE against EAC-bearing mice. Conclusion: PASE had a potent anticancer activity than PDSE due to their phytochemical’s contents.
  Ismail Moustafa Al-Sharkawi , Sabry Ali El-Naggar , Kamal Abd El-Slam El-Sheikh and Hany Mokhtar Al-Wahsw
  This study aims to evaluate the susceptibility of the hedgehog (Hemiechinus auritus) to Schistosoma mansoni under the experimental condition. The susceptibility of this animal to S. mansoni infection was compared to the hamster (Permissive host) infection with the same parasite. In this study, 24 male of both hedgehogs and hamsters were used. Half of animals were infected with 250 S. mansoni cercariae. Eight weeks post infection; animals were sacrificed to determine the total worm burden, total eggs count, granuloma volume. The results revealed that a fecal examination of the infected hedgehogs showed no eggs were detected in the feces. The average of hamster’s pre-patent period (the onset of patency) was 44.0±1.0 days. The average of S. mansoni worms recovered from hedgehogs was 31.0±10.0 worms, while the worm recovered from hamsters was 82.0±18.0. The granuloma volume measured from hedgehogs and the hamsters were 74.0±56.0 and 119.0±75.0, respectively. Marked reduction in the some biochemical parameters after the infection with S. mansoni was recorded in infected hedgehogs and hamsters. In conclusion, the hedgehogs showed non possibility for this animal to be a risk for schistosomiasis in the field.
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