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Articles by S.M. Jain
Total Records ( 2 ) for S.M. Jain
  Y.B. Solanki and S.M. Jain
  The present study was undertaken to investigate hepatoprotective activity of Clitoria ternatea seed and root and Vigna mungo seed against acetaminophen- and carbon tetrachloride-intoxicated rats. The liver functioning was evaluated by measuring serum marker enzymes and hepatic fibrosis was accessed by measuring collagen content in terms of p-hydroxyproline levels. Mast cell infiltration and potentiation of phenobarbitone-induced sleeping time were also measured. In addition, serum bilirubin, creatinine, lipid peroxidation and antioxidant parameters were also estimated. C. ternatea and V. mungo seed extracts significantly (p<0.05) decreased SGOT, SGPT, ALP and total bilirubin in both acetaminophen and CCl4 - intoxicated rats. The C. ternatea root extract, showed similar results only in CCl4 - intoxicated rats. These findings were further supplemented by histopathological studies of liver tissues. Hepatic collagen content as evident from decreased (p<0.05) hydroxyproline levels and hepatic mast cell infiltration were significantly decreased in extracts pre-treated animals. In addition, C. ternatea and V. mungo seed extracts significantly (p<0.05) reduced hepatic lipid peroxidation as evident from the decreased MDA, increased antioxidant enzymes activities and GSH levels in the liver tissues. The V. mungo seed extract significantly potentiated barbiturate-induced sleeping time. The findings of study suggested that C. ternatea and V. mungo possess potent hepatoprotective activity. The hepatoprotective activity of C. ternatea could be attributed to antioxidant properties and prevention of pre-inflammatory changes. The hepatoprotective activity of V. mungo could be attributed partly to the hepatic microsomal enzyme inhibition and partly to the antioxidant properties.
  Y.B. Solanki and S.M. Jain
  Background: Clitoria ternatea is important ayurvedic medicinal plant known as Butterfly pea and reported to have nootropic, anxiolytic, tranquilizing, anti-inflammatory, analgesic, antipyretic, antimicrobial and immunomodulatory activities. Present study was undertaken to investigate the wound healing activity of C. ternatea seed and root extracts. The effects on wound healing were investigated using excision, incision and dead-space models in rats. The extracts were standardized by HPTLC method. Results: C. ternatea seed and root extracts significantly improved wound healing in excision, incision and dead-space models when administered orally by gavage as well as applied topically as ointment. These effects are comparable to that of cotrimoxazole ointment. The finding of the study suggested that C. ternatea affects all three phases-inflammatory, proliferative and remodeling phases of wound healing. Plant extracts were found to contain phenolic compounds and seed extract was containing flavonol glycosides. Conclusion: The present study demonstrated wound healing activity of C. ternatea in animal models. The flavonol glycoside and phenolic compounds present in plant may be responsible for altering the inflammatory and immune component of wound healing.

Kay words: Aparajita butterfly pea, flavonoids, phenolic, wound healing

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