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Articles by S.K. Sharma
Total Records ( 8 ) for S.K. Sharma
  Ashutosh Jamloki , C. Karthikeyan , S.K. Sharma , N.S. Hari Narayana Moorthy and P. Trivedi
  A quantitative structure-activity relationship study on 6-aryl-pyrazolo (3,4-b) pyridines was performed to gain structural insight into the binding mode of the molecules to the glycogen synthase kinase -3α, an enzyme phosphorylate and inhibit Glycogen Synthase (GS) which is the rate limiting enzyme in the glycogen biosynthesis. The molecular modeling studies were performed using CS Chem. Office 2001 molecular modeling software version 6.0. Allinger`s MM2 force field by fixing Root Mean Square Gradient (RMS) to 0.1 Kcal mol-1 and semiemperical AM1 Hamiltonian method (MOPAC module) were used to minimize the energy and calculate descriptors. The thermodynamic and steric features of 6-aryl-pyrazolo (3,4-b) pyridines are highly correlated with GSK-3α inhibitory activity. The results of the study suggests that introduction of bulky groups at C-5 position of the pyrazolopyridine ring will increase the GSK-3α inhibitory potency as it may involve in hydrophobic interaction with the ATP binding site of the enzyme. The results of the study reveal that the conformational rigidity and orientation of molecule play significant role in the GSK-3α inhibitory activity. Additionally, electronic interactions between molecule and enzyme were found to be crucial for GSK-3α inhibitory activity.
  V.K. Gupta and S.K. Sharma
  In this study, antioxidant activity of aqueous extract of Ficus bengalensis Linn. (FBWE) root was investigated for its free radical scavenging activity by adopting various in vitro models. The extract was investigated for its antioxidant activity by 1,1-diphenyl, 2-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing capacity, hydrogen peroxide activity, determination of total phenolic content using Folin-Ciocalteu’s phenolic reagent. FBWE showed maximum scavenging of DPPH radical (96.07%) at 250 μg mL-1 concentration and hydrogen peroxide (69.23%) at 1000 μg mL-1 concentration. Reducing power was also dose dependent and total phenolic content evaluated that 1 mg of FBWE contains 25.34 μg equivalent of gallic acid. The extract showed significant results when compared with the standard compounds.
  S.K. Sharma and J. Mahanta
  The present study is an attempt to evaluate the relationship of haemoglobinopathies, particularly Hb E and Plasmodium falciparum malaria in northeastern region of India. The diverse autochthonous inhabitant of this part of India exhibits variable gene frequency for βE-globin gene. The geo-climatic condition of the region supports transmission of Plasmodium falciparum malaria in northeastern parts of India. The study revealed that HbE is predominant with a variable gene frequencies in ethnic groups affiliated to Tibeto-Burman linguistic families. Prevalence of Hb E is also associated with the linguistic affiliation of various Tibeto-Burman linguistic families inhabiting in malaria endemic northeast India. We have also observed a positive correlation (R2 = 0.703) of βE-globin gene frequency and mean incidence of Plasmodium falciparum infection (Pf %) in malaria endemic zones.
  B.P.S. Thakur , S.K. Sharma , Arvind Sharma and Adarsh Kumar
  Veterinarians working under remote field conditions are routinely presented with variety of surgical interventions in equines like castrations, management of wound, traumatic and congenital hernias and musculoskeletal disorders thus necessitating the use of general anaesthesia for management of these conditions. The present study was carried out to evaluate and recommend the suitable short term anaesthetic technique for Spiti ponies under field conditions. Seven clinically healthy male Spiti ponies presented for castration were evaluated for short term Total Intravenous Anaesthesia (TIVA) using detomidine (0.02 mg kg-1), butorphanol (0.01 mg kg-1), 5% guaifenesin (20 mg kg-1) and ketamine (2.0 mg kg-1). The studies conducted were open label trials and all the animals received same treatment. After proper tetanus prophylaxis and preanesthetic fasting, detomidine was administered intravenously. Subsequently at head down position the animals received butorphanol intravenously. Thereafter, guaifenesin was administered intravenously. As soon as the signs of ataxia developed, the induction of surgical anaesthesia was achieved by intravenous administration of ketamine hydrochloride. The onset of sedation was observed in 2.43±0.53 min following detomidine administration and the animals were ataxic in 1.43±0.43 min after butorphanol and guaifenesin administration when ketamine was injected. The ponies were in surgical plane of anaesthesia within 2.28±0.42 min following ketamine administration. During recovery the limb/head movement and sternal recumbency were attained in 18.71±1.98 and 26.14±1.62 min, respectively whereas standing ataxia and normal gait were seen at 29.42±3.21 and 71.14±4.74 min, respectively. There was excellent to good muscle relaxation. The surgical anaesthesia remained for 22.57±1.48 min. The recovery was smooth. Moderate to good suppression of palpebral and corneal reflexes were observed immediately after induction and during anaesthesia. The analgesia was excellent. A highly significant (p<0.01) to significant (p<0.05) decrease in respiration rate was observed after induction, during anaesthesia and after recovery. The mean SpO2 value in equines of this group was 76.50±4.14 and 83.33±4.18% after induction and during anaesthesia, respectively. Some of the blood biochemical parameters like plasma alanine amino transferase (ALT), total proteins and glucose showed significant increase without clinical consequence. It was concluded that detomidine (0.02 mg kg-1), butorphanol (0.01 mg kg-1), guaifenesin 5% (20 mg kg-1) and ketamine (2.0 mg kg-1) combination can safely be used for short term total intravenous anaesthesia in equines under field conditions where the monitoring facilities are meager.
  V. Jain , S.K. Verma , S.K. Sharma and S.S. Katewa
  Bombax ceiba Linn. (Red Silk Cotton Tree) commonly known as Semal tree; is a multipurpose tree species of tropical forests; providing food, fodder, fibre, fuel and medicine besides many ecological benefits. It is a dominant plant species of tropical dry deciduous forests of Southern Rajasthan, India. The present work is an attempt to justify the role of B. ceiba as an umbrella or life support tree for many animal species in forest areas of Southern Rajasthan. During the study period, total 43 animal species were observed who visited B. ceiba either for food, shelter or roosting purposes. Out of these, 29 species were from Avian fauna, 11 species belonged to Mammalia, two species belonged to Arthropoda and one from Reptilia. The present study confirms use of B. ceiba for balancing forest ecosystems and further recommends that this drought tolerant, easily propagable plant species should be planted in dotted fashion in forests specially in protected areas and also in home gardens as a keystone resource for many animal species.
  R. Maan , N. Kataria , P.K. Pilania , A. Sharma , S. Arora , A. Joshi , L.N. Sankhala , S.K. Sharma , N. Mohammad , P. Nathawat and A.K. Kataria
  Serum Superoxide Dismutase (SOD) profiling was carried out in the Marwari breed of sheep from arid tracts in India. Animals were categorized according to sex and age. Blood samples were collected during moderate, extreme hot and cold ambiences to harvest sera. Mean value of serum SOD during moderate ambience was 171.76±2.72 kU L-1. Moderate mean value was considered as control. The mean value of serum SOD was significantly (p≤0.05) higher during hot and cold ambiences as compared to control. Mean value was 2.57 times higher in hot ambience and 1.54 times higher in cold ambience as compared to control. The sex and age effects were significant (p≤0.05) in all ambiences. The mean values were significantly (p≤0.05) higher in male animals than female animals. In each ambience the age effect showed a significant (p≤0.05) increase in the mean values being highest in the animals of 2.5-4.5 years of age. Increased SOD activities during extreme ambiences indicated the development of oxidative stress. Present study generated data of SOD which can be used as reference values for future studies and for diagnostic purposes. The pattern of variation of SOD activity indicated modulation of adaptive mechanisms to protect the body from changes in ambient temperatures and on this basis use of antioxidants in the animals during changing environments is recommended.
  Taruna Bhati , A.K. Kataria , P. Nathawat , S.K. Sharma , N. Mohammed and M. Mathur
  The present study was undertaken to determine the efficacy of 32 different antibiotics against 38 S. aureus isolates obtained from milk samples from cattle with subclinical mastitis. About 6 antibiotics, i.e., Azithromycin, Gentamycin, Chloramphenicol, Tobramycin, Netillin and Neomycin were found 100% effective followed by Methicillin and Linezolid (94.74%), Cotrimoxazole (92.11%), Nitrofurazone (92.10%), Enrofloxacin (89.47%), Bacitracin (84.21%) and Sparfloxacin, Amoxyclav, Cefaclor and Amoxycillin (81.58%). The resistance was 71.05% for Vancomycin and Polymyxin B, 50% for Oxytetracycline, 47.37% for Azlocillin and 36.84% for Novobiocin whereas Cefixime and Metronidazole were completely (100%) ineffective against all the isolates.
  N. Mohammed , S. Solanki , T. Bhati , P. Nathawat , S.K. Sharma , S. Kumar , A. Joshi , P.K. Pilania , L.N. Sankhala , M. Mathur , A. Ahuja , N. Kataria and A.K. Kataria
  The present study was carried out on 17 positive cases (horses) of colic. Two cases died during the treatment. Ten apparently healthy equines (horses) were also included in the study which constituted control group. Clinico-physiological observations included clinical signs, temperature, pulse, respiratory rate per min and colour of mucosa and were noted daily before start of treatment. Laboratory diagnosis of equine colic was done by determining haematological parameters. Blood samples from control group as well as equines suffering from colic were subjected to haematological examinations comprising of haemoglobin, packed cell volume, total erythrocyte count, total leucocyte count, differential leucocyte count and platelet count. There was great variation in duration and severity of clinical manifestations. In all the cases abdominal pain, loss of appetite, depression and change in colour of mucous membrane from light pink to dark pink was present. Pulse rate, respiration rate and capillary refill time were increased highly significantly (p<0.01) than the mean values from control group but temperature was within normal range and non-significantly (p>0.05) changed. In present study haemoglobin, PCV and TEC counts was increased significantly (p<0.05) on 1st day (before treatment) in comparison to healthy control group and after-treatment group. There was non significant (p>0.05) difference in their values between control group and after treatment group. Pattern of variation observed in the present study regarding haematological parameters of colicky cases can contribute in generating data for future studies and in laboratory diagnosis.
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