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Articles by S.I. Inya-Agha
Total Records ( 2 ) for S.I. Inya-Agha
  S.I. Inya-Agha , S.C. Ezea and O.A. Odukoya
  Hypoglycemic activity in Picralima nitida Stapf (Apocynaceae), recorded as an index of blood glucose was confirmed in normal and intraperitonially induced alloxan diabetic albino rats with glibenclamide as reference standard and normal saline as control. Toxicity study was evaluation of acute (15 days) tests. 100, 300 and 900 mg kg-1 of the extracts to normal rats resulted in significant (p<0.01) lowering of fasting blood sugar after 8 h. Extract maintained hypoglycemic action throughout the 24 h of study indicating a long duration of action. In normal rats, pulp extract (100 mg kg-1) produced a maximum percentage reduction of 38.35%, rind extract (900 mg kg-1) 46.19% and seed extract (100 mg kg-1) 36.81%. Alloxan induced rats were pulp 85.85% (300 mg kg-1), seed 83.26% (300 mg kg-1) and rind 80.25% (900 mg kg-1), respectively. Order of activity recorded as pulp > seed > rind. Acute toxicities (LD50) of pulp, seed and rind were 7071.06, 948.68 and 1364.91 mg kg-1, respectively. Analytical standards were moisture content, ash and extractive values for quality assurance.
  M.O. Sofidiya , O.A. Odukoya , O.B. Familoni and S.I. Inya-Agha
  The present research evaluates the DPPH radical scavenging, total antioxidant activities, reducing power and total contents of phenolic compounds in methanolic leaf extracts of five Nigerian medicinal plants (Dalbergia saxatilis Hook.f. (Papilionacae), Ekebergia senegalensis A.Juss.(Meliaceae), Hymenocardia acida Tul. (Hymenocardiaceae), Icacina tricantha Oliv. (Icacinaceae) and Salacia pallescens Oliv.(Celastraceae). Total phenols were analysed according to the Folin-Ciocalteu method. Each sample under assay condition, showed a dose-dependent effect both on free radical scavenging 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and also on Fe3+ reducing power. The antioxidant activity of the plant extracts with the DPPH radical scavenging and reducing power method, were in the order Hymenocardia> Ekebergia> Salacia> Icacina> Dalbergia. H. acida and E. senegalensis possess very high radical scavenging activity in both assays. Potency of H. acida extract was of the same magnitude as that of reference α-tocopherol. Total phenols in all the samples expressed as GAE (Gallic Acid Equivalent) varied from 1.83 to 15.47mg g-1 of dry plant material. Total antioxidant activities correlated with total phenols (R2 = 0.6640) an indication that 66% of the antioxidant capacity of these extracts results from contribution of phenolic compounds. A linear positive relationship existed between the reducing power and total phenolics of the tested plant extracts (R2 = 0.9564).
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