

Articles
by
S.G. Ahmed 
Total Records (
4 ) for
S.G. Ahmed 





S.G. Ahmed


In the present study, planar oxidation problem is solved using a new developed integral technique. The technique starts by assuming a profile for oxygen concentration for oxidized and metallic layers, respectively. The two profiles contain three unknowns such that one of them is common between the two layers, which is the moving (oxidation) front. Apply the first order integral moment in each layer, separately, yields the main unknown in the assumed profiles, meanwhile, the moving front remains unknown. By achieving the energy balance at the moving boundary yields a nonlinear equation, its solution iteratively, yields the location of the moving boundary at each time step. The results of the present method were compared with the analytical solution and gave a good agreement between the two solutions. 





S.G. Ahmed
,
J. Umana
and
U.A. Ibrahim


This study evaluated the premenstrual and menstrual haematological parameters of female SCD patients with menstruation induced Vasoocclusive Crises (VOC) with the aim of identifying any significant changes that might be etiologically associated with the crises. Fifteen female patients with sickle cell anemia (Hb SS) and history of menstruation induced VOC were studied along side equal number (15) of age and sex matched patients without history of menstruation induced VOC. Patients without history of menstruation induced VOC had mean premenstrual values of haematocrit, total leucocyte count and platelet count of 0.26 L L^{1}, 12x10^{1} L^{1} and 458x10^{9} L^{1}, respectively, which were not significantly different from the corresponding mean menstrual values of 0.25 L L^{1} for haematocrit, 11.5x10^{9} L^{1} for total leucocyte count and 452x10^{9} L^{1} for platelet count (p>0.05). Patients with history of menstruation induced VOC had mean premenstrual values of haematocrit and total leucocyte count of 0.25 L L^{1} and 11.8x10^{9} L^{1}, respectively, which were not significantly different from the corresponding mean menstrual values of 0.24 L L^{1} for haematocrit and 12.3x10^{9} L^{1} for total leucocyte count (p>0.05). However, the mean menstrual platelet count of 605x10^{9} L^{1} was significantly higher than the mean premenstrual value of 452x10^{9} L^{1} (p<0.05). This data would suggest that high menstrual platelet count was aetiologically associated with the development of menstruation induced VOC. There is therefore the need to investigate a possible beneficial role of low doses of antiplatelet agents in preventing or managing menstruation induced VOC. 




S.G. Ahmed
and
U.A. Ibrahim


This study is aimed at finding out whether or not activation of the coagulation system and fibrin deposition occurs in Chronic Myeloid Leukaemia (CML) patients with Hyperleucocytic Syndromes (HLS). A total of 14 CML patients with HLS were evaluated with respect to white cell count, presence of symptoms and signs of HLS and plasma Ddimer levels. Equal number of sex and age matched CML patients without HLS were similarly evaluated. Patients with HLS had a significantly (p<0.05) higher mean white cell count of 510x10^{9} L^{1} as compared to their counterparts who did not present with HLS and had a mean white cell count of 120x10^{9} L^{1}. All CML patients without HLS had normal levels of Ddimer with a mean value of 87 ng mL^{1}. However, among the CML patients with HLS, 78.6% had elevated Ddimer levels with a mean value of 325 ng m L^{1}, while the remaining 21.4% had normal Ddimer levels with a mean value of 95 ng m L^{1}. This data was interpreted to indicate that in the majority of cases of CML with HLS, microvascular endothelial damage and fibrin deposition occur and contribute to the microvascular blockade initiated by leucostasis. There is therefore, the need to investigate a possible beneficial role of low dose anticoagulation in mitigating secondary fibrin deposition and minimizing tissue infarction and sensory organ damage in such patients. 





S.G. Ahmed
,
U.A. Ibrahim
and
A.W. Hassan


This study was conducted to determine the potential usefulness of sicklable red cells as surrogate markers for Hb S in monitoring Exchange Blood Transfusion (EBT) in Sickle Cell Anaemia (SCA) patients in resource limited health institutions. A total of 5 patients with SCA who had EBT at the University of Maiduguri Teaching Hospital, Nigeria, were monitored by serial densitometric Hb S quantitation as well as estimation of the proportion of sicklable red cells after each cycle of EBT. The proportion of sicklable red cells were estimated with the use of microscope (x40 objective) from glass slide preparations for sickling test made by standard technique using dithionite. The mean values of Hb S levels and proportions of sicklable red cells that were obtained before the EBT (preEBT) and after each cycle of EBT from all the five patients were analyzed using SPSS version 11.0 to determine the coefficient of correlation. The mean levels of Hb S and proportions of sicklable red cells fell in parallel from preEBT values of 93 and 100% to 17 and 19% at the end of the 5th cycle, respectively. The proportion of sicklable red cells fell to a target level of less than 20% after cycle5, by which time the Hb S level was even much lower than 20%. Linear regression analysis between the mean values of Hb S and sicklable red cells revealed a strong positive correlation coefficient, r = +0.992 (p = 0.01). Hence, sicklable red cells can be used as useful and safe surrogate markers for Hb S in the monitoring of SCA patients on EBT. This may be an attractive model for resource limited health institutions that manage SCA but lacks modern Hb quantitation facilities. 





