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Articles by S.A. Adesegun
Total Records ( 3 ) for S.A. Adesegun
  S.A. Adesegun , N.A. Elechi and H.A.B. Coker
  Methanolic extract of Macaranga barteri Mull-Arg (Euphorbiaceae) was investigated for antioxidant properties using different in vitro tests, including DPPH free radical scavenging, reducing, inhibition of linoleic acid lipid peroxidation, iron chelating power. The total phenolic content was also determined and expressed in gallic acid equivalent. The antioxidant activities increased with increasing concentration of the extract to certain extent then level off with further increase. The radical scavenging activity of the extract was comparable to that of BHT and ascorbic acid and no significant difference between them (p>0.05). The extract of M. barteri showed strong inhibition of lipid peroxidation in linoleic acid system and moderate reducing properties. It demonstrated poor iron chelating capacity compared to EDTA used as positive control, suggesting metal chelation plays very little role in antioxidant properties of the extract. This study showed that the leaf extract of M. barteri is a potential source of antioxidants.
  S.A. Adesegun , N.A. Elechi and H.A.B. Coker

The stem bark extract of S. ellipticum (Hochst) Pax was investigated for its antioxidant properties in this study. The extract was evaluated for antioxidant activity in vitro in terms of its ability to inhibit lipid peroxidation and its free radical scavenging, reducing and metal chelation powers. The total amount of phenolic compounds in the extract was also determined in terms of gallic acid equivalent. The extract produced effective free radical scavenging and reducing activities in a dose dependent fashion. The extract exhibited noticeable inhibition of lipid peroxidation of linoleic acid emulsion. These activities were less than that of ascorbic acid and 2,6–Di–tert–butyl–47–methylphenol used as positive controls. The extract however demonstrated poor iron chelating ability compared to ethylene diamine tetraacetic acid. The total phenolic content of the extract was 50.61±0.08 mg g-1 in terms of gallic acid. This study showed that the stem bark extract of S. ellipticum exhibits significant antioxidant activity and is a good source of natural antioxidants.

  R.K. Obi , A.A. Anjorin , B.O. Oke , O.B. Salu , S.A. Adesegun , T.I. Adeleke , O.A. Olayinka , O.S. Ogunsemowo , J.A. Shenge , O.A. Adedeji , B.O. Ajuwon , J.O. Adeleke , K.M. Salawu and S.A. Omilabu
  Background and Objective: Viruses cause a variety of illnesses in humans, yet only a few antiviral drugs have been developed. This study was therefore designed to evaluate three potentially useful medicinal plants locally available in Nigeria for possible therapeutic applications against genetically and functionally diverse virus families public health importance. Materials and Methods: Fresh leaves of Bambusa vulgaris, Moringa oleifera and seed of Citrus paridisi were collected from Lagos State, South Western Nigeria. Extraction of the plant materials was done with methanol, chloroform, water and n-hexane using the Soxhlet extractor and concentrated using the rotary evaporator. Results: Results obtained showed that n-hexane extracts of B. vulgaris and M. oleifera inhibited measles virus at the concentrations of 0.125 and 0.016 μg μL–1, respectively. Similarly, while aqueous extract of M. oleifera inhibited measles at 0.125 and 0.063 μg μL–1, aqueous extract of C. paridisi inhibited the virus at 0.031 μg μL–1. While none of the extracts of M. oleifera and C. paridisi produced any inhibitory activity against HSV-1, n-hexane extract of B. vulgaris was able to inhibit the virus at 0.125 μg μL–1. Results of the mechanism of action of the extracts on the replicative cycle of the viruses revealed both adsorption/entry and post infection inhibitors of the viruses. Phytochemical analysis of the extracts revealed the presence of terpenes, alkaloids, flavonoid, tannins, combined and free anthraquinones, cardiac glycosides and saponins. Conclusion: This study has shown that indigenous medicinal plants are invaluable broad spectrum agents in the development of efficacious antiviral cocktails against RNA and DNA viruses of public health importance in Nigeria.
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