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Articles by S. Sasidharan
Total Records ( 3 ) for S. Sasidharan
  A. Hussain , S. Sasidharan , T. Ahmed , M. Ahmed and C. Sharma
  Cervical cancer is the second most common carcinoma in the world among women and is highly chemoresistant and radio resistant, often resulting in local treatment failure. For locally advanced disease, radiation is combined with low-dose chemotherapy; however, this modality often leads to severe toxicity. Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary agents have become not only important potential chemopreventive, but also therapeutic agents when combined with chemotherapy or radiotherapy. In this study, we observed that gemcitabine was highly cytotoxic to both cancer and normal cells while clove extract (0.7-8 mg mL-1) was found to be comparatively more cytotoxic towards cancer cells. Notably, combination of low dose gemcitabine and ethanolic clove extract (2 and 3 mg mL-1) had more pronounced cytotoxic effect on cancer cells than single modalities. It is noteworthy that use of clove extract increased the efficacy of gemcitabine and importantly, it was found to be minimally toxic to normal cells. Together, these results suggest a novel mechanism may be involved in the synergistic effect of this combination.
  N. Krishnan , S. Ramanathan , S. Sasidharan , V. Murugaiyah and S.M. Mansor
  The aim of the present study was to characterize the antimicrobial properties of various crude extracts of the Cassia spectabilis leaf against bacteria and yeast. Acetone, n-hexane, dichloromethane, ethyl acetate and methanol extracts of C. spectabilis leaves were evaluated in vitro against Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram negative bacteria (Escherichia coli, Salmonella typhi and Pseudomonas aeroginosa) and yeast (Candida albicans). The Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were determined using micro dilution assay. Methanol showed the highest yield (14.12%) followed by dichloromethane (8.37%), acetone (6.66%), ethyl acetate (4.76%) and n-hexane (1.80%). Acetone and methanol crude extracts showed a good antimicrobial activity with MIC values ranging from 0.625 to 2.5 mg mL-1 and MBC or MFC values ranging from 1.25 to 5 mg mL-1. The MIC, MFC and MBC values of these extracts were 10 to 80 times less potent than standard antimicrobial drugs, amoxilin and miconazole nitrate.
  L. Yoga Latha , I. Darah , K. Jain and S. Sasidharan
  The methanol extract of Vernonia cinerea Less (Asteraceae), which exhibited antimicrobial activity, was tested for toxicity. In an acute toxicity study using mice, the median lethal dose (LD50) of the extract was greater than 2000 mg/kg, and we found no pathological changes in macroscopic examination by necropsy of mice treated with extract. As well as the oral acute toxicity study, the brine shrimp lethality test was also done. Brine shrimp test LC50 values were 3.87 mg/mL (6 h) and 2.72 mg/mL (24 h), exhibiting no significant toxicity result. In conclusion, the methanol extract of V. cinerea did not produce toxic effects in mice mice and brine shrimp.
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