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Articles by S. Nanda
Total Records ( 2 ) for S. Nanda
  S. Mishra and S. Nanda
  Sperm DNA fragmentation is known to compromise male fertility. The data entail that sperm DNA damage can be efficiently treated with oral antioxidant administration during a relatively short time period. It is an understanding that the 2 types of DNA appear to be distinct and independently packaged molecules; however, research has demonstrated the symbiotic nature of these structures in contributing to male infertility. Data must continue to be gathered to establish strong correlations between traditional semen analysis parameters and sperm DNA integrity; this information remains controversial and useless in clinical practice until new techniques for the diagnosis and treatment of sperm DNA can be established. More modern technology must be employed to correlate such information into useful clinical knowledge. This study is the compilation of reports pertaining to research on sperm DNA biochemistry and molecular biology to establish an opinion that sperm DNA integrity is both extremely fragile and exceedingly important for male fertility.
  A. Shirwaikar , Y. Kamariya , B. Patel , S. Nanda , V. Parmar and S. Khan
  The objective of this study was to evaluate the effect of methanol extract of the fruits of Morinda citrifolia Linn., on osteoporosis induced by ovariectomy in female albino rats at two different dose levels of 500 and 750 mg/kg/day. Healthy female albino rats in the age group of 90 days were selected and randomized into five groups of six animals each. Group 1 was sham operated and served as control while all the remaining groups were ovariectomized. Group 2 was fed with an equivolume of saline and served as ovariectomized control. Group 3 was orally treated with standard Raloxifene (5.4 mg kg-1) whereas the methanol extract of Morinda citrifolia (500 and 750 mg kg-1) was administered to the groups 4 and 5. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters, showed that the methanol extract significantly reduced bone loss, as evidenced by a reduction in Tartrate Resistant Acid Phosphatase (TRAP) and urine Hydroxyproline (Hp) levels while simultaneously increasing bone formation [high serum Alkaline Phosphatase (ALP) levels], thereby restoring bone mineralization. The restoration of bone strength was confirmed by biomechanical parameters viz., the three point bending of tibia, load testing of femoral head and compression of IV lumbar vertebra and it was further endorsed by histopathological findings i.e., bone microarchitecture. The extract significantly increased the osteoblastic activity on one hand while on the other it retarded the osteoclastic function thereby contributing to a positive bone balance and hence enhanced mineralization.
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