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Articles by S. Kalavathy
Total Records ( 3 ) for S. Kalavathy
  A. Vijaya Anand , M. Chandrasekharan , S. Kalavathy , K. Uma , M.P. Saravanan , A. Mohamed Saleem Gani , K. Vijaya Kumar , R. Senthil and P. Sampath Kumar
  The present study was designed to determine the effects of atorvastatin on C-Reactive Protein (CRP) and lipid profile in patients with stroke, since their anti-inflammatory properties have been investigated recently. Ninety five patients with or without stroke were recruited for the study, of which 60 belongs to control (untreated) and 35 were test group (treated) and received daily with 10 mg day-1 of atorvastatin. The patients were followed for over a period of 3 months. For entire study population, CRP along with lipid profile, Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) were measured 1st day and at the end of 3rd month of the treatment. Treatment with atorvastatin decreases both inflammatory activity and atherogenic lipoproteins. The results of this study will provide important information on how to maximize the therapeutic benefits of atorvastatin in a broader range of patients at risk for cerebrovascular morbidity and mortality.
  N. Manoharan , P. Sampathkumar , B. Dheeba , S. Sheikabdulla , G. Vinothprasanna , R. Vinothkannan , S. Kalavathy , A. Vijayaanand and A. Shanmugasundaram
  The hepatoprotective activity of the marine algae Gracilaria corticata was investigated against aflatoxin B1 (AFB1) induced hepatotoxicity. AFB1 (1 ppm) induced hepatic damage was studied by assessing parameters such as body weight gain, liver weight, total protein, albumin and enzyme markers viz., transaminases (SGOT and SGPT), Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP). The effect of co-administration of aqueous extract of G. corticata on the above parameter was further investigated. Hepatic damage was evidenced by significant (p<0.05) decreased level of body weight gain, liver weight, total protein and albumin. Co administration of rats with the aqueous extract of G. corticata showed a tendency to attain near normalcy. Elevated levels of total bilirubin, SGOT, SGPT, LDH and ALP in aflatoxin B1 intoxicated rats were restored to normal level in the rats treated with aqueous extract (250 mg kg-1 body weight) and aflatoxin B1. Thus the study substantiates the hepatoprotective potential of aqueous extract of G. corticata.
  A. Vijaya Anand , S. Kalavathy , M. Chenniappan , P. Sampath Kumar , N. Manoharan , S. Sheik Abdulla , R. Chandrasekar and B. Hari Krishnan
  The present study was designed to evaluate the association of inflammatory marker C-reactive protein (CRP) alone and in combination with lipid profile in the prognosis of coronary artery disease (CAD) since the cardio vascular disease (CVD) is considered to be a multifactorial disease driven by inflammatory reactions. One hundred and fifty patients were recruited for the study, of which, 75 belongs to control and 75 were test group. For the entire study population CRP and lipid profile were measured. Among the patients with complication (test group), there was a significant elevation in the levels of CRP and lipid profile than the control. It was also found that a combination of measurement of CRP with total cholesterol (TC) or low-density lipoprotein (LDL) cholesterol testing may proven to be even a better marker of risk response in patients with CAD.
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