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Articles by S. Sanni
Total Records ( 2 ) for S. Sanni
  F.I. Abdulrahman , P.A. Onyeyili , S. Sanni and V.O. Ogugbuaja
  This study investigated the sub-acute effects of aqueous root bark extract of Vitex doniana on some serum elemental components as well as serum biochemical parameters in rats. Serum sodium levels were significantly (p<0.05) increased following extract treatments while those of potassium were decreased. The extract decreased serum calcium concentration but no marked effect was observed on serum phosphorus concentration. The cholesterol level also decreased in the rats treated with higher concentration of extract (100 and 200 mg kg-1), while the protein concentration in the serum of treated animals was comparable with that of control except at 200 mg kg-1 which showed significant (p<0.05) decrease in protein level at 21 days of extract treatment. Levels of liver marker enzymes and blood urea nitrogen in the extract treated rats increased in a dose-dependent manner and could be due to the pathological lesions in the liver and kidney which are the main excretory system. The aqueous extract of Vitex doniana though used for the management of some illness such as diarrhea, jaundice, anemia, mental illness, rheumatism and as tranquilizer in man, has been observed in rats under the conditions of this study to be toxic to both the liver and kidney.
  F.S. Sanni , S. Ibrahim , K.A.N. Esievo and S. Sanni
  The anti-anaemic effect of Khaya senegalensis stem bark on phenylhydrazine-induced anaemia was carried out in rats. Induction of anaemia was conducted using phenylhydrazine hydrochloride at a dose of 750 mg kg-1 body weight. In vivo investigation showed that oral daily dose of 300 mg kg-1 body weight of the bark aqueous extract of K. senegalensis in rats administered simultaneously with the phenylhydrazine produced significant (p<0.05) anti-anaemic effect probably by protecting the red blood cells against destruction by phenylhydrazine. However, the same oral dose did not show any significant curative effect (p>0.05) after the induction of anaemia using phyenylhdrazine hydrochloride. The phytochemical screening of the aqueous extract of the stem bark of K. senegalensis indicate the presence of carbohydrate, saponin, glycosides and tannins. Also present are important mineral elements necessary for the development and functioning of the body. These include calcium, magnesium, zinc, iron, copper, potassium, and sodium. This study showed that Khaya senegalensis has an anti-anaemic effect.
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