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Articles by S. H Hong
Total Records ( 3 ) for S. H Hong
  K. H Jung , Y. S Cho , S. H Hong , W. H Chung , G. J Lee and S. D. Hong

Objective  To measure subjective outcomes after primary and revision surgery for chronic ear disease.

Design  Prospective questionnaire-based outcome study.

Setting  Tertiary referral center.

Patients  Adults with chronic otitis media with or without cholesteatoma.

Interventions  Primary or revision surgery for chronic ear disease.

Main Outcome Measures  The Chronic Ear Survey, a disease-specific outcome survey, was administered preoperatively and at 1 year after surgery. We analyzed the total score and the activity restriction, symptom, and medical resource utilization subscale scores. Scores were averaged on the basis of the number of questions included in each category. Differences in preoperative and postoperative scores were analyzed within and between the 2 groups. We also assessed audiometry, postoperative complications, and the clinical condition of the operated-on ear.

Results  Twenty-one patients were enrolled in the primary surgery group, and 20 were enrolled in the revision surgery group. Significant improvements in the total score and each subscale score were observed in both groups at the 1-year postoperative survey. Improvements in the total score and symptom subscale scores were greater in the primary surgery group than in the revision surgery group (P < .05). The air conduction thresholds and any postoperative clinical problems were correlated with the total score and subscale scores in the primary group but not in the revision surgery group.

Conclusion  Comparable objective outcomes are achieved after primary and revision surgery for chronic ear disease, but the improvement in quality of life is greater in the primary surgery group.

  J. Y Um , C. H Jang , K. Y Kim , S. J Kim , N. H Kim , P. D Moon , I. Y Choi , N. Y Myung , H. J Jeong , S. H Hong and H. M. Kim

Auditory dysfunction is related to large/small vessel occlusions and hemorrhage. Sudden sensorineural hearing loss (SSNHL) frequently occurs with anterior inferior cerebellar artery occlusion proximal to the internal auditory artery. Moreover, SSNHL has various pathogenetic mechanisms, the main proposed mechanisms being vascular disease, membrane ruptures, infection, and autoimmunity. Tumor necrosis factor (TNF) is an important cytokine in the inflammation process of cerebrovascular diseases. In the current study, the possible effects of polymorphisms in TNF- and TNF-β genes on SSNHL are evaluated. Two genetic polymorphisms in the TNF locus (TNF- —308 G - ->A and TNF-β +252 A - ->G) were investigated as risk factors for SSNHL by determining their prevalence in 97 SSNHL patients and in 587 controls. A significant increase was found for the TNF-β allele 1 in SSNHL patients compared with the controls ( 2 = 7.251, P = .007, odds ratio [OR] = 1.534, confidence interval [CI] = 1.12-2.10). These findings suggest that the TNF-β +252 locus plays an important role in the etiopathogenesis of SSNHL.

  I Lee , S. S Ajay , J. I Yook , H. S Kim , S. H Hong , N. H Kim , S. M Dhanasekaran , A. M Chinnaiyan and B. D. Athey

MicroRNAs (miRNAs) are known to post-transcriptionally regulate target mRNAs through the 3'-UTR, which interacts mainly with the 5'-end of miRNA in animals. Here we identify many endogenous motifs within human 5'-UTRs specific to the 3'-ends of miRNAs. The 3'-end of conserved miRNAs in particular has significant interaction sites in the human-enriched, less conserved 5'-UTR miRNA motifs, while human-specific miRNAs have significant interaction sites only in the conserved 5'-UTR motifs, implying both miRNA and 5'-UTR are actively evolving in response to each other. Additionally, many miRNAs with their 3'-end interaction sites in the 5'-UTRs turn out to simultaneously contain 5'-end interaction sites in the 3'-UTRs. Based on these findings we demonstrate combinatory interactions between a single miRNA and both end regions of an mRNA using model systems. We further show that genes exhibiting large-scale protein changes due to miRNA overexpression or deletion contain both UTR interaction sites predicted. We provide the predicted targets of this new miRNA target class, miBridge, as an efficient way to screen potential targets, especially for nonconserved miRNAs, since the target search space is reduced by an order of magnitude compared with the 3'-UTR alone. Efficacy is confirmed by showing SEC24D regulation with hsa-miR-605, a miRNA identified only in primate, opening the door to the study of nonconserved miRNAs. Finally, miRNAs (and associated proteins) involved in this new targeting class may prevent 40S ribosome scanning through the 5'-UTR and keep it from reaching the start-codon, preventing 60S association.

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