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Articles by S Horie
Total Records ( 3 ) for S Horie
  T Kodama , N Tomita , S Horie , N Sax , H Iwasaki , R Suzuki , K Maruyama , S Mori and F. Manabu

Sonoporation is achieved by ultrasound-mediated destruction of ultrasound contrast agents (UCA) microbubbles. For this, UCAs must be tissue specific and have good echogenicity and also function as drug carriers. Previous studies have developed acoustic liposomes (ALs), liposomes that encapsulate phosphate buffer solution and perfluoropropane (C3F8) gas and function as both UCAs and drug carriers. Few studies have examined the co-existence of gas and liquid in ALs. This study aims to elucidate AL structure using TEM. The size, zeta potential and structure of ALs were compared with those of two other UCAs, human albumin shell bubbles (ABs; Optison) and lipid bubbles (LBs). ABs and LBs encapsulate the C3F8 gas. Particle size was measured by dynamic light scattering. The zeta potential was determined by the Smoluchowski equation. UCA structure was investigated by TEM. ALs were ~200 nm in size, smaller than LBs and ABs. ALs and LBs had almost neutral zeta potentials whereas AB values were strongly negative. The negative or double staining TEM images revealed that ~20% of ALs contained both liquid and gas, while ~80% contained liquid alone (i.e. nonacoustic). Negative staining AB images indicated electron beam scattering near the shell surface, and albumin was detected in filament form. These findings suggest that AL is capable of carrying drugs and high-molecular-weight, low-solubility gases.

  N Mugii , M Hasegawa , Y Hamaguchi , C Tanaka , K Kaji , K Komura , I Ueda Hayakawa , S Horie , M Ikuta , K Tachino , F Ogawa , S Sato , M Fujimoto and K. Takehara

Objective. To assess red blood cell velocity in finger nail-fold capillaries using video capillaroscopy in patients with SSc and other collagen diseases.

Methods. This study included 127 patients with SSc as well as patients with SLE (n = 33), DM/PM (n = 21), RA (n = 13) and APS (n = 12), and 20 healthy subjects. Red blood cell velocity was evaluated using frame-to-frame determination of the position of capillary plasma gaps.

Results. The mean red blood cell velocity was significantly decreased in patients with SSc compared to healthy controls (63.0% reduction) and patients with other conditions. Mean blood velocity was similar between patients with dcSSc and lcSSc. Importantly, even SSc patients with normal or non-specific nail-fold video capillaroscopic (NVC) patterns or a scleroderma early NVC pattern exhibited a significantly lower red blood cell velocity compared to healthy controls (51.7 and 61.4% reduction, respectively) or patients with other conditions, despite normal or mild capillary changes. Patients with the scleroderma active and late NVC pattern showed a more decreased blood velocity (65.5 and 66.2% reduction, respectively). This reduced blood velocity was significantly associated with NVC findings, including capillary ramification and capillary loss. Although remarkably reduced velocity was observed in SSc patients with intractable digital ulcers (72.1% reduction), it was significantly improved by lipo-prostaglandin E1 (lipo-PGE1) infusion.

Conclusion. Our results suggest that reduced blood velocity is a hallmark of SSc. Furthermore, measurement of red blood cell velocity may be useful in evaluating therapeutic effects on microcirculation.

  N Idota , S Horie , T Tsutsui and J. Inoue

To assess the risk of hearing loss among workers using earphones as communication devices at noisy worksites, we compared temporary threshold shifts (TTS) between ears on which workers wore earphones and ears on which no earphones were worn. We measured ambient noise and personal noise exposure as well as noise generated by and passed through earphones by applying frequency analysis at three pinball facilities during their hours of actual operation. We assessed hearing levels before and after a work shift (prework and postwork) of 54 workers by pure tone audiometry at six frequencies. The time-weighted averages for ambient noise and personal noise exposure exceeded 85 dB(A) and 90 dB(A), respectively. Overall sound pressure levels generated by and passing through earphones reached 109 dB(A). The one-third octave band spectrum of the earphone noise during the shift exceeded 90 dB(SPL) in the range of 315–2000 Hz. The number of ears demonstrating a TTS, defined as a shift of 10 dB or more in postwork over prework hearing thresholds, was significantly greater at 1500 and 2000 Hz among ears with earphones (P < 0.05 and P < 0.01, respectively) compared to those without. The reverse was observed at 4000 Hz for ears without earphones (P < 0.01). Workers wearing earphones or headsets as communication devices in noisy environments are exposed to high risk of hearing loss, particularly at the frequencies of 1500 and 2000 Hz. Ideally, hearing conservation programs for such workers should account for potential hearing losses at frequencies of 2000 Hz or lower frequencies induced by amplified voice signals.

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