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Articles by Rokia Anwar
Total Records ( 3 ) for Rokia Anwar
  Amany H. Mansour , Tawfik R. Elkhodary , Rokia Anwar , Maha Ragab Habeeb and Mohammed Amin Mohammed
  Hepatocellular Carcinoma (HCC) is the major form of primary liver cancer and the third leading cause of cancer mortality worldwide. HCC is frequently diagnosed at an advanced stage, resulting in rather poor survival rates. CD133, a trans-membrane glycoprotein, is an important cell surface marker for both stem cells and Cancer Stem Cells (CSCs) in various tissues including the liver. CD133 has been used as the Tumor Initiating Cells (TICs) marker in HCC. Further identification and characterization of CSCs or TICs in HCC are necessary to better understand hepatic carcinogenesis. So, the objective of this study was to estimate the level of the specific markers as CD133 and transforming growth factor β (TGF-β) in HCC. Fifty peripheral blood samples were collected from HCC patients. The CD133 protein expression was analyzed by flow cytometry and TGF-β levels were assayed by ELISA. This study revealed a higher expression of CD133+cells in all HCC patients. The expression of CD133+cells was positively correlated with clinical, pathological and laboratory parameters. A mild to moderate positive correlation was found with tumor size, male gender, pathological grade, Hepatitis C virus and Alpha-fetoprotein and showed a strong positive correlation between age, TGF-β, Lymph node metastasis, portal vein tumor thrombosis and CD133+cells in peripheral blood. CD133+cells might represent true CSCs in HCC which could allow a better understanding of HCC initiation and progression, as well as possibly bear great therapeutic implications. Moreover, the multifunctional cytokine TGF-β plays a crucial role in the regulation of CD133 expression in HCC.
  A.H. Mansour , Mohammed Amin Mohammed , Rokia Anwar , M.E. Elzafrany and Nesreen Moustafa Omar
  There is growing evidence that the ABO blood group system may play a role in disease etiology. Studies conducted several decades ago, have demonstrated a relationship between inherited human ABO and Rhesus blood groups and risk of various malignancies. However, these findings are inconsistent and contradictory. The objective was to perform analysis of ABO and Rhesus blood antigens distribution among patients with various cancers including breast, hepatocellular, pancreatic, gastric, skin, lung cancers, leukemia and lymphoma in Dakahlia, Egypt and to assess their potential role in carcinogenesis. A total of 1131 cancer patients (age 63.8±9.3, female/male, 215/916) and another 1200 healthy controls (age 48.9±11.3, female/male, 348/852) were enrolled in this study. ABO blood groups were determined using Tube method and Gel method. The anti-TF IgG level and Von Willebrand factor were determined by enzyme-linked immunosorbent assay. The distribution of blood type A was significantly higher among cancer patients than among healthy controls (39.35 vs. 33.75%, p = 0.014), whereas, the distributions of other blood types were similar between cases and controls (p>0.05). Most cancers, especially gastrointestinal tumors were dominated by male gender independent of age. Blood group A was associated with significantly higher risk for malignancy including hepatocellular carcinoma, pancreatic and breast cancers while biliary and esophageal cancer risk was significantly associated with blood type B. We suggest that blood group A may elevate risk of cancer and may play a role in its development.
  Mohammed Amin Mohammed , Rokia Anwar , Amany H. Mansour , Emad Elmasry and Gamal Othman
  Obesity is a chronic multi-factorial disease associated with serious increases in adiposity, morbidity and mortality rates. Ghrelin, leptin and adiponectin complexly interact to modulate appetite and mediate metabolic processes. The objective was to evaluate the effects of Bioenteric Intragastric Balloon (BIB) versus conservative therapy (diet and physical exercise) on plasma ghrelin, leptin, insulin and adiponectin in obese subjects. A total of 128 adult consecutive morbidly obese individuals were randomized into: BIB group comprised 84 patients treated with Intragastric Balloon and control group comprised 44 obese patients treated with conservative treatment only. In BIB group, insertion of balloon caused a significant reduction in body mass over a 6-months period compared with the control group. After one month, the levels of ghrelin increased significantly then gradually decreased, reaching the starting level three months after the removal of the balloon. Also, leptin level decreased significantly. In the control group, the corresponding of ghrelin and leptin levels remained relatively stable. In BIB group, adiponectin significantly increased as opposed to a transient increase in the control group. Conclusion: intragastric balloons in association with low-calorie diet are effective, safe, reversible, but short-lasting therapeutic endoscopic intervention in obese patients. The treatment with BIB causes significant changes in the levels of appetite-regulatory hormones beside a body mass reduction, changes in carbohydrate and lipid metabolism and improved co-morbidities.
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