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Articles by Robert A. Ngala
Total Records ( 2 ) for Robert A. Ngala
  Robert A. Ngala and Albert Adu Asare
  The pathogenesis of type 2 diabetes is a complex phenomenon. Many research works have implicated obesity and dyslipidaemia as possible causes of type 2 diabetes mellitus. The aim of this study was to determine the association between BMI, oxidative stress and skeletal muscle mass in the aetiology of type 2 diabetes. The study was conducted at the Komfo Anokye Teaching Hospital, Kumasi Ghana. The study involved 120 diabetic subjects and 80 non diabetics as control, matching age and sex with the diabetics. Anthropometric parameters measured include height, weight, waist circumference, hip circumference, thigh circumference, plasma glucose was determined by the enzymatic method and plasma creatinine concentration by the Jaffe reaction using creatinine reagent. Urine sugar was estimated using a urine test strip. Malonyldialdehyde level in serum was estimated spectrophotometrically according to the Buege and Aust method. The body mass index was significantly higher in the diabetics than the controls (26.45±6.49 and 22.13±3.30 kg m-2) (p<0.001), respectively. Fasting blood glucose levels were obviously higher in the diabetics than in the non-diabetics (9.925±0.544 and 5.448±0.88 mmol L-1) (p<0.0015). Serum MDA concentration was significantly higher in the diabetics than the controls (0.29±0.03-0.23±0.02 μmol L-1 (p<0.0502) while Serum creatinine of the diabetics was non significantly lower than that of the controls (98.70±53.94-101.9±34.00μmol L-1 (p<0.3677). Overweight, skeletal muscle and oxidative stress may play a significant role in the aetiology of type 2 diabetes or at least aggravate the diabetes.
  Robert A. Ngala
  Diabetes mellitus was a rare disease in Africa. However, Africa is now emerging as one of the most rapid epidemiological transitions of non-communicable diseases and especially diabetes, overwhelming to Africa’s health care systems. A decade back, the prevalence of diabetes Mellitus in Rural Sub-Saharan Africa was 0-2.2% and that of for Urban Sub Saharan Africa, 2.2-6.7%. Insulin and other hypoglycemic drugs are expensive. The improvement of many African economies into middle-income status is associated with an increasingly sedentary lifestyle and increased prevalence of diabetes. Many of the traditional dietary preparation known to ameliorate diabetes and other chronic diseases have been abandoned for westernized foods. Reverting to original/traditional diets may be an answer to addressing the diabetes pandemics. Free fatty acids have been reported to impair insulin action, Dietary fat composition has been implicated in the development of insulin resistance as well as fasting hyperglycaemia and type 2 diabetes mellitus. This study has shown the benefits of consuming vegetable oils on the management of diabetes in diabetic mice. Diet fortified with non-refined red palm oil, (Elaeis guineensis), groundnut oil (Arachis hypogaea) and coconut oil (Cocos nucifera) have been shown to have a hypoglycemic effect. Insulin and other hypoglycaemic drugs are expensive. A paradigm shift, back to traditional diets using these vegetables and vegetable oils in appropriate proportions and good calorific value would help to reduce the requirement of insulin and other hypoglycemic drugs.
 
 
 
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