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Articles by Rehab Fawzi Kasem
Total Records ( 3 ) for Rehab Fawzi Kasem
  Dina Soliman Khater , Rehab Fawzi Kasem and Reham Awad Morsy
  Background and Objective: Odontogenic tumors comprise a complex group of lesions which can pretense diagnostic challenges because of overlapping and diverse histopathologic types and clinical behaviors. An understanding of the biological behavior of these lesions is of fundamental importance for the final diagnosis and treatment planning, as these have an influence on the prognosis. The goal of the present study was to analyze and correlate the immunohistochemical expression of NF-κB and its transcription targets Bcl-xL and COX-2 in different odontogenic tumors. Materials and Methods: Thirty paraffin blocks of different odontogenic tumors (six dentigerous cyst, fourteen simple ameloblastoma, five unicystic ameloblastoma and five ameloblastic carcinoma) were selected. Immunohistochemistry was performed using the standard method (Avidin biotin peroxidase) to detect the polyclonal anti-NF-κB, Bcl-xL and COX-2 antibodies. One-way ANOVA and Spearman correlation test was used for statistical analyses. Results: The overall expression of the three antibodies (NF-κB, Bcl-xL and COX-2) increased significantly (p-value was considered significant when p<0.05) from dentigerous cyst to ameloblastoma and reached their highest values in the cases of ameloblastic carcinoma. Conclusion: The interaction between the three proteins in blocking apoptosis and increasing proliferation may constitute an important pathogenic mechanism of tumorigenesis and hence might play a role in the behavior of odontogenic tumors.
  Rehab Fawzi Kasem , Dina Soliman Khater , Ghada A. Abdel-Latif and Olfat Gamil Shaker
  Background and Objective: Identification of molecular targets for oral cancer is essential for developing therapeutic approaches that target those molecules. The miR-34a is a tumor suppressor gene and a transcriptional target of p53 protein. Bax is a pro-apoptotic protein which is activated by p53 and a target of miR-34a. The present study was designed to evaluate the expression levels of p53 and its transcriptional target miR-34a in oral squamous cell carcinoma cell line and to correlate this expression with their apoptotic target Bax. Materials and Methods: A total of 26 paraffin blocks were selected including 6 cases of normal oral mucosa, 10 cases of well differentiated oral squamous cell carcinoma and 10 cases of poorly differentiated oral squamous cell carcinoma. Sections from each block were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-34a and p53 relative gene expression and immunohistochemical analysis was done to determine Bax protein expression. Results: The three studied proteins showed higher expression in normal oral mucosa than well differentiated oral squamous cell carcinoma and a lower expression in poorly differentiated oral squamous cell carcinoma. A statistically significant direct correlation was observed between the gene expression level of miR-34a and the expression level of Bax protein among studied cases and between the level of p53 gene expression and Bax protein expression. Conclusion: p53 dysfunction in oral carcinogenesis might lead to dysregulation of miR-34a and loss of apoptotic mechanism which gives the chance for the cancerous cells to proliferate and survive.
  Samar Ali Altowity , Amal Hassan Abdel-Rahman , Rehab Fawzi Kasem and Mohammed Mahmoud Elsebaie
  Background and Objective: Bisphosphonates (BPs) have become the primary class of drugs prescribed for the management of bone pathologies associated with excessive bone resorption. Their use has been associated with significant side effect, Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ). The conventional non-surgical and surgical approaches in several BRONJ lesions are sometimes insufficient, therefore, alternative therapies that are safe and that enhance the osteogenesis and angiogenesis are needed. Mesenchymal stem cells (MSCs) have great potential for clinical therapy and have many applications in various fields of regenerative medicine. This study was conducted to evaluate the effect of MSCs on the healing (regenerative) potentials of the bone in bisphosphonate-induced osteonecrotic teeth socket. Materials and Methods: To generate BRONJ-like model, twenty-four adult male rats were received zoledronic acid (Zometa, 0.1 g kg–1 b.wt., twice per week) and dexamethasone (5 mg kg–1 b. wt., once in week) intraperitoneally. At 4 weeks after drugs injection, unilateral left mandibular first molar was extracted and at 3 weeks after teeth extraction, rats were divided randomly into two groups; MSCs group (treated by MSCs topical application) and control group (left without treatment). After euthanization, the mandible of all rats were dissected out and prepared for histopathological examination using H and E staining, Masson trichome as well as immunostaininig with osteopontin. Results: Signs of bone healing and regeneration were significantly detected in osteonecrotic teeth sockets which were treated with topical application of MSCs in comparison to control group. Conclusion: MSCs topical treatment approach might help in restoring, maintaining or improving defective tissue functions that have been compromised by BRONJ.
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