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Articles by Rasha S. Mohamed
Total Records ( 3 ) for Rasha S. Mohamed
  Doha A. Mohamed , Sherein S. Abdelgayed , Rasha S. Mohamed and Hend A. Essa
  Background and Objective: Hyperthyroidism and hypothyroidism are the most common disorders of thyroid function. The current study aimed to evaluate the prophylactic effect of safflower petals and moringa leaves crude ethanol extracts against thyroid dysfunctions (hyper and hypothyroidism). Materials and Methods: Forty-two rats were divided into 7 groups, control normal, hyperthyroidism control, hyper-safflower, hyper-moringa, hypothyroidism control, hypo-safflower and hypo-moringa. L-Thyroxine (0.3 mg kg1 b.wt.) and carbimazole (10 mg kg1 b.wt.) were orally administrated for 3 weeks as hyperthyroid and hypothyroid inducer, respectively. Blood hemoglobin, plasma thyroid-stimulating hormone (TSH), glucose, catalase activity, lipid profile as well as liver and kidney functions were assessed. Histological examination of thyroid gland was carried out. Results: The results revealed that hyper and hypothyroidism mediated decrease and increase in TSH values, respectively. Oral administrations of either safflower petals extract or moringa leaves extract improve plasma levels of TSH. Oxidative stress and disturbance in plasma glucose, lipid profile as well as liver and kidney functions were occurred in conjunction with thyroid dysfunctions especially hypothyroidism. Administration of safflower petals extract or moringa leaves extract alleviates the reduction in catalase activity, hyperglycemia and disturbance in lipid profile as well as liver and kidney functions accompanied with thyroid dysfunctions especially hypothyroidism. Conclusion: The studied extracts have prophylactic potential against thyroid dysfunctions and the subsequent oxidative stress, hyperglycemia and changes in lipid profile. Crude ethanol extract of safflower petals was promising as prophylactic agents in hyper and hypothyroidism as observed by improving plasma levels of TSH, lipid profile and histopathological changes.
  Doha A. Mohamed , Sherein S. Abdelgayed , Hend A. Essa and Rasha S. Mohamed
  Background and Objective: Non-alcoholic fatty liver disease (NAFLD) is a public health problem presenting one of the most important common forms of liver diseases worldwide. This study was carried out to investigate the protective effect of two functional foods in form of bread containing purslane seeds meal and garden cress seeds against NAFLD. Materials and Methods: High fat and high cholesterol diet were used for induction of NAFLD in rats for 6 weeks. Plasma lipid profile (total cholesterol, triglycerides, high density lipoprotein-cholesterol and low-density lipoprotein-cholesterol, hepatic lipid profile (total fat, cholesterol, triglycerides), malondialdehyde (MDA), as well as liver (AST, ALT, total and direct bilirubin) and kidney (creatinine and urea) functions were assessed. Histological examination of liver tissue was carried out. Results: Results revealed that significant elevation in plasma and liver lipid profiles, MDA, liver enzymes (AST and ALT), bilirubin (total and direct) and kidney function (creatinine and urea) were observed in NAFLD control compared to normal control. Feeding rats on diet containing functional food I and II (purslane and garden cress bread, respectively) showed significant improvement in all the studied parameters with remarkable effect regards to functional food I (purslane bread). Conclusion: Purslane bread and garden cress bread as functional foods prepared in the present study prevent weight gain, improve plasma lipid profile and prevent hepatic lipid accumulation effectively in NAFLD model in rats. Also decreased lipid peroxidation, improve liver and kidney functions and possess hypoglycemic effect. Purslane bread was superior in the prevention of hepatic lipid accumulation.
  Ahmed M.S. Hussein , Rasha S. Mohamed , Karem Aly Fouda , Manal F. Salama and Mona M. Hussein
  Background and Objective: Vitamin A Deficiency (VAD) is a critical public health problem that affects the health of kids worldwide and may induce anemia and oxidative stress. The current study aimed to pre-clinically assess the effect of a cupcake, prepared to be served for primary school children, on vitamin A deficiency and related anemia and oxidative stress in rats. Materials and Methods: Flour of flash orange sweet potatoes, as a rich source of pro-vitamin A, was used to prepare the cupcake. The chemical composition, amino acids and sensory evaluation of the cupcake were done. The biological evaluation was carried out using 18 weaning rats in three groups (control group, vitamin A-deficient group and vitamin A-deficient group fed on a diet fortified with 20% of the prepared cupcake for two months). Results: The results indicated the high value of vitamin A in the prepared cupcake. Excellent sensory characteristics were noticed. Feeding on the VDA diet fortified with the prepared cupcake suppressed the reduction in Retinol-Binding Protein (RBP), hemoglobin and iron. Total Iron Binding Capacity (TIBC) increased in the VAD group. Also, feeding on the prepared cupcake suppressed the reduction in Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) and the elevation of Malondialdehyde (MDA). Conclusion: It can be suggested that the prepared cupcake is promising in preventing of vitamin A deficiency and related anemia and oxidative stress. Thus, the prepared cupcake may be efficient for children to prevent vitamin A deficiency.
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