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Articles by Ramandeep Singh
Total Records ( 4 ) for Ramandeep Singh
  Sarabjeet Singh , Ashraf Ali , Ramandeep Singh and Ramandeep Kaur
  The inability to have child is a personal tragedy and a large proportion of childless people are confronted with social stigmatization and frustration. Erectile dysfunction is one of the commonest disorders of male sexual function. Among the methods used to treat male infertility problems, medicinal plants have been used empirically as extracts, decoctions, fractions or semi-purified compounds. These herbal products are used in the treatment of a dysfunctioning of the libido, sexual asthenia, erection and sperm disorders. Penile erection depends on a complex interaction of psychological, neural, vascular and endocrine factors. Testosterone has an important role in both central and peripheral domains of this process. Pharmacological activities of many plants have been shown in vitro using cells, in vivo (on laboratory animals) and human studies. Plants provide a treatment option that is affordable and available for infertile couples and phytotherapy is an essential form of treatment in our health system .In this review, we have summarized most of the data dealing with role of testosterone and the effects of plant extracts on mammalian reproductive functions.
  Ramandeep Singh , Ashraf Ali and Sarabjeet Singh
  In India, indigenous remedies have been used in treatment of sexual dysfunction since the time of Charaka and Sushruta. Plants have always an exemplary source of drugs and many of the currently available drugs have been derived directly or indirectly from them. An aphrodisiac is defined as an agent that arouses sexual desire. Erectile dysfunction or Sexual dysfunction (ED or SD) or male impotence is defined as the inability of a man to achieve and maintain an erection sufficient for mutually satisfactory intercourse with his partner. Sexual health and function are important determinants of quality of life. To overcome the problem of male sexual erectile dysfunction various Indian natural aphrodisiac plants potentials were preferred. The ethnobotanical information reports that about 200 plants possess aphrodisiac potential. Out of several Indian medicinal plants 33 plants were reviewed. In this review, studies on Indian medicinal plants were reviewed and their possible therapeutic applications were discussed. This review discuss about aphrodisiac potential of Indian medicinal plants, its botanical name, Common name, family, extract, models used, part used and references, which are helpful for researcher to development new herbal aphrodisiac formulations. In the recent years, interest in drugs of plant origin has been progressively increased.
  Yogesh Sharma , G. Jeyabalan and Ramandeep Singh
  Wound is defined as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound healing consists of integrated cellular and biochemical events leading to re-establishment of structural and functional integrity with regain of strength in injured tissues. Naturally, the investigative curiosity to promote healing continues since ages. A lot of research has been envisaged to develop better healing agents and it has been a challenging task to generate them and keep pace with the problems encountered. Several drugs of plant, mineral and animal origin are described in the ayurveda for their wound healing properties. In the present review, attempts are made to understand various aspects of wounds and discuss about wound healing potential of plants, its botanical name, common name, family, part used, extract used, dose, study duration and references, which are helpful for researcher to development new wound healing formulations for human use.
  Ramandeep Singh , Alok Semwal and Satinder Kakar
  Depression is a chronic, recurring and potentially life-threatening illness that affects up to 20% of the population across the world. Despite its prevalence and considerable impact on human, little is known about its pathogenesis. One of the major reasons is the restricted availability of validated animal models due to the absence of consensus on the pathology and etiology of depression. Numbers of synthetic derivatives are available for the treatment of this fatal disease but are associated with serious complications. A wide diversity of animal models has been used to examine antidepressant activity. These range from relatively simple models sensitive to acute treatment, to highly sophisticated models that reputedly model some aspect of depressive illness. The number of validated animal models for affective disorders is large and still growing. A basic understanding of the underlying disease processes in depression is lacking, and therefore, recreating the disease in animal models is not possible. For the animal model of depression, the relevance, reliability and reproducibility in laboratories need to be focused, currently used models of depression attempt to produce quantifiable correlates of human symptoms in experimental animals and the animal modeling remains a potentially important approach towards understanding neurochemical and neurobiological mechanisms in depression. Animal models of depression attempt to represent some aspect of the etiology, symptomatology and treatment of the disorders, in order to facilitate their scientific study. Hence, this review deals with animal models that are beneficial for evaluating the potential of antidepressants. The present review further discusses the ability of currently available animal models for depression to investigate the novel hypothesis.
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