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The purpose of this study is to determine the effectiveness of an inquiry learning models to improve
student mastery of concepts and their creative thinking. This research was conducted in a class of year 12
students at a vocational school using a pre-test and post-test control group design. Data collection was
conducted using pre-test, post-test, observation and questionnaire. Improvement of creative thinking skills for
the group of students has the highest control on the indicators of building knowledge that has been possessed
by students with N-gain 0.40 with the medium category, the lowest on the indicator of seeing limited information
with N-gain 0.15 with the low category. Increased mastery of concepts and creative thinking skills of students
caused by the use of inquiry learning models in effective colloidal subject matter with a sig. (2 tailed) value
<0.05, namely there are differences in the increase in mastery of concepts and creative thinking skills after the
application of inquiry learning models compared to the control class. Students and teachers respond positively
to the learning process with the inquiry learning model.