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Articles by R. Saghiri
Total Records ( 3 ) for R. Saghiri
  F. Pourfallah , S. Javadian , Z. Zamani , R. Saghiri , S. Sadeghi , B. Zarea , F. Mirkhani , N. Fatemi and T. Kordi
  The purpose of this study was to evaluate the levels of Zinc, Copper, Iron and Copper/Zinc ratio in the serum of adult patients with pulmonary tuberculosis in Iran. Serum levels of Zinc and Copper were determined by flame atomic absorption spectrophotometer and serum iron concentration was measured by using an Auto Analyzer. The study group consisted of 50 pulmonary tuberculosis patients before treatment and after 6 months of anti-tubercular therapy. Levels of serum Zn (p<0.001) and Fe (p<0.001) in TB patients were significantly increased after 6 months of anti-tubercular therapy. However, serum Cu concentration (p<0.01) and Cu/Zn ratio (p<0.05) were decreased after 6 months of anti-tubercular therapy. Some studies indicated a strong association of Zn, Cu, Fe and the Cu/Zn ratio with TB. In this study, we found remarkable change in Cu/Zn ratio. Some researchers mentioned that serum Cu/Zn ratio could be used as an important laboratory marker for diagnosis and treatment of tuberculosis. They also mentioned that trace element levels must be closely monitored during the process of disease.
  F. Pourfallah , S. Javadian , Z. Zamani , S.D. Siadat , Sh- Khatami , R. Saghiri and T. Kordi
  This study was a cross-sectional descriptive study and done in four seasons during April 2011 to March 2012.The objective of the present study was to examine Physico-chemical properties of groundwater around Tehran. The results are also compared with the guideline values of Iranian legislation. A total of 160 drinking water samples were collected from different drinking groundwater around the Tehran. Total Dissolved Solids (TDS), conductivity and pH, were measured by using standard methods and the concentration of ions Cl¯, F¯, NO3¯, NO2¯, Br¯, SO42¯, PO43¯, Ca2+, K+, Na+ and NH4+ in groundwater was performed using Ion chromatography (Metrohm Company, USA) with standard method. This study showed that most of the parameters in groundwater were below the Iranian permissible limit except total dissolved solids (N = 2), conductivity (N = 2), nitrate as NO3¯ (N = 22), chloride (N = 3), sulphate (N = 2), fluoride (N = 3) and ammonia (N = 8). There were significant differences (p<0.05) between physico-chemical parameters such as pH, nitrite (NO2¯), sodium, potassium, sulphate, ammonia, bromide and phosphate in different seasons. These results are important, not only for the many people who drink groundwater but also for the health supervisory agencies such as Ministry of Health and Institute of Standards and Industrial of Iran (ISIRI) to have more effective control on groundwater.
  E. Salehizadeh , H. Nahrevanian , M. Farahmand , R. Hajihosseini , R. Saghiri and G. Khalili
  Killed Leishmania Vaccine (KLV) has been applied for its immunogenicity in hosts. Imiquimod (IMQ) as adjuvant induces immune responses during leishmaniasis. In this study, KLV/IMQ were applied to inhibit the proliferation and visceralization of Leishmania major in mice. Animals were treated with KLV/IMQ, then they infected by promastigotes of L. major. Six weeks later, a small nodule was appeared leading to a large lesion and visceralisation. KLV/IMQ effects on physiopathology, lesion sizes, lesion delay, amastigote proliferation and leishmania detection in target organs were all studied. Data analysis of body weight, hepato/splenomegaly and survival rates indicated no significant differences among experimental groups. It is concluded that KLV/IMQ represented no cytotoxic effects but they partly had effects on lesion size and impressed number of amastigotes inside macrophages. Application of KLV/IMQ decreased visceralization in liver; induced NO in liver, spleen and plasma. Although, IMQ application solely decreased visceralization in lymph nodes but KLV/IMQ increased SGOT/SGPT, however they represented no effects in concentrations of plasma Cu/Zn. Unlike IMQ topical application, its injection presented no ameliorative affects on CL, however its inhibition systemic leishmaniasis is indicated here. IMQ efficacy may be associated with route, dose and number of injection, which require more investigations.
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